<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07715

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPAGALTNFRVIDDFFDIFWRIYSIVAPESDGSQFGPVESSTLRNSNEIWSSLFALRNAGCLVSQLADRPELWIFSASPDFDALARASGNHQPREGLIVAGNATFLNVASGVNTAAEIKQHLLSGPSSSIFNGAATQNRLSPHVGEYSQLQNLATYSAFHEALLSSISKTVTLQFTRQQKVVPLGTRTLYASLNENEYQGGEDSPLARKSTPFLSTLDINLTSKGRLVISLSTLPQPGLEQLHHDSESDIIATRLNDDVWLAPSGTLCRLTSTSEYQSSLSNVVSPDPMGTTPHHAELPADKINANKREWKKNVSEWLKMFGLHLNNPESEFWVEVEVNVSDRPFCDLFSKSALNHQKSSPFIRILWPGRLCFTRSRSKLTAPANPTEFFSGQSESPLQFAERWVKEVCWISQPIDKHKSSDDQSGLENQQLKRSEPSPLRLDRSDMPESLARTINMPEAQLASAVYPTPPGGALAQYMGAGSISERLGTSTIDTLSYAPTQTESIYNEAGGPTTYFRGNSEILPTALDPASSELGIGSGLYDTAADEEFFGDMDVANFDTKGITEADFNFFDEPDFTGLTDNLDMQTEEPELAQQHAESNLATPYNSNTAMSIAEPNPSNTNQGHLITTKNGNGRIKHSGVSPLNTTAAEGQISEGITQPRQLILTDGLRRRPMSPPLSPVQIKKILSPDVSSPLPSKPLNSKISKSCPAKNQYSPVIFQPTLWTSDKKYRMDGRFWFTPGSQHITRNLRSYPSDIPTIGFPQKGKNVRPKPPSIHTSSGPLVSDNAPEIDLQSPSTSSYGSSDYDSDTDRGSNASSPHIIQFHSKRKRDSEGGGNSTPSHLERLTQASDVDNGTLNEHELALLSIFISGAVDWPLAGYFSRIQNDVFPVFSRREDLLQTAQLVVDQVTQSSFCHVHDDLYMPEWVDWDDVLSQSLFDNTDGLGHMSKLDLRSYTTLEDGSNPRKEVPSIRPSIPGSIYKISSPHVKVHRGNSYLEILPPAIGFWETFGLEPLQGEKNIIPFCIYPPNVSEAADAFMERLTLVYSSGNFGSHSRPKKANGLVPWSLNAASDQDYASLMHALNVSCEILGSALSNILASDENVVIYIINPFVYDAAIVDICSAFLRLFHKYVGDADRQHTRRLNELVLQIIPLEFIASPDSLVVPTQTDYLRLALEVYSRCPPKDRSSDWLGCAPPLVLAEPVPKVVPFRLAPESITPVEEAKCLHVAYSQSVDQRWVTAAWTDNSGRHQTALSYCLRERNSPVSRPISEIRTQIWETTKDIMDMSSSHWRLIIVKDEPVDSEEIDMWKSLLDQYNRHKAIKVELGIVSVNTKPGLSLRLPSSPLQFSALSQQPTQNGLSTVTPGSTPRPVPSPDPSGPAATPPTATTPMFADQQQATPPQQQPQQLTTDSDQDTILIDKSDETWGVTLSHRLNSSYSLTKYQPALASGYLLRRSGTSDTDGQAVMTVNVIYTNSRRPIDHLLKDILRMYRELITLARVRGIVHVQGNLPLPWHIMTAVKGQEVLSYTL
Length1531
PositionKinase
OrganismBlastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.08
Grand average of hydropathy-0.398
Instability index53.95
Isoelectric point5.41
Molecular weight169090.51
Publications
PubMed=26439490

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07715
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     280.40|      70|     147|     210|     291|       1
---------------------------------------------------------------------------
  210-  284 (115.91/66.58)	RKSTPFlstldINLTSKGRLVISLS....TLPQPGLEQLHHDSESDI.IATRLNDDV.W.LAPSGTLCRLTSTSEYQSSLSN
  359-  431 (105.62/51.72)	QKSSPF.....IRILWPGRLCFTRSrsklTAPANPTEFFSGQSESPLqFAERWVKEVcW.I..SQPIDKHKS.SDDQSGLEN
 1400- 1448 (58.88/24.76)	.............................TPPQQQPQQLTTDSDQDT.ILIDKSDET.WgVTLSHRLNSSYSLTKYQPAL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.37|      19|      24|     576|     597|       3
---------------------------------------------------------------------------
  576-  594 (34.34/24.64)	EPDF.TGLTDNLDMQTEEPE
  601-  620 (29.03/11.97)	ESNLaTPYNSNTAMSIAEPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     177.63|      44|     676|     657|     720|       4
---------------------------------------------------------------------------
  657-  703 (72.03/40.37)	SEGITQPRQLiLTDGLRRRPMSPPLSPVQIKKilSPDVSSPLPSKPL
 1304- 1347 (74.21/32.74)	SEEIDMWKSL.LDQYNRHKAIKVELGIVSVNT..KPGLSLRLPSSPL
 1365- 1381 (31.39/26.79)	TPGST.PR...........................P.VPSPDPSGP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.47|      40|     710|     441|     482|       5
---------------------------------------------------------------------------
  441-  482 (66.98/43.48)	PLRLDRSdmPESLARTINMPEAQLASAVYP.TPPGGALAQYMG
 1154- 1194 (68.48/38.38)	PLEFIAS..PDSLVVPTQTDYLRLALEVYSrCPPKDRSSDWLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.78|      22|     676|     325|     348|       6
---------------------------------------------------------------------------
  325-  348 (38.13/25.21)	LHLNNPESEFW.......VEVEVNVSdrPFC
  998- 1026 (36.65/18.31)	LEILPPAIGFWetfglepLQGEKNII..PFC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.18|      22|     668|     125|     146|       7
---------------------------------------------------------------------------
  125-  146 (39.36/21.87)	LSGPSSSIFNGA.......ATQNRLSPHV
  795-  823 (32.82/16.84)	LQSPSTSSYGSSdydsdtdRGSNASSPHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.92|      17|      23|     502|     524|       9
---------------------------------------------------------------------------
  502-  518 (32.00/26.37)	PTQTESIYNEAG.GPTTY
  527-  544 (25.91/ 7.43)	PTALDPASSELGiGSGLY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07715 with Med13 domain of Kingdom Fungi
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