<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07713

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSHAPPPSSVHPGPPSSPSSPAADRTKPHQLYQQNHPKDQTPHTPTSPPLMSVSAQNYASSFSTTRTSPAQTFQFGSLSSPPSSVAMSTQVSQQPTVTSTTSFPTPASSAGGNFVNNLTIDEAEGIAKNGTTDSRKDGESYTGKEVGLDVMDIDTSEHRRTDHDRQKRGADKIPDDNTMDLDHRAASSTQEEELKLSALRQNIGTAFHLCKSSYTASGPNPSLDLISLYGLGPVASSVARTDPVTGEKINRLRKSYEGKIKGLGLAGRNKPVKAEPGATGGLKYLTLWPEEEWQNQKVYGKDIKVAAPDSSFFRQQLKAMKMEPGVLPNHEIWEDALGHEKASKVMVANDASMAKAAGTVPGSIRQPVHTNGTPSMISTPATEYTRPKRTGKKRSYNDSSFVGYGEGFPDDEVDLDSGRYSNSEEGGRGQGKKKRKKDHISGVSPNLSERSGSYGVGMFGVGAR
Length464
PositionHead
OrganismBlastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Blastomyces.
Aromaticity0.06
Grand average of hydropathy-0.810
Instability index45.71
Isoelectric point8.79
Molecular weight49775.51
Publications
PubMed=26439490

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP07713
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.98|      36|      88|     275|     312|       1
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  275-  312 (62.35/41.58)	EPGATGGLKYLTLWPEEEWQNQKVYGKdiKVAAPDSSF
  366-  401 (66.63/38.73)	QPVHTNGTPSMISTPATEYTRPKRTGK..KRSYNDSSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.72|      35|      40|       3|      42|       2
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    3-   42 (62.68/44.70)	HAP..PP.SSVhpGPPSSPSSPAADRTKPHQLYQQ.......NHPkdqTP
   43-   74 (37.53/15.08)	HTPtsPPlMSV..SAQNYASSFSTTRTSPAQTFQ................
   76-  106 (29.52/10.27)	.............GSLSSPPSSVAMST...QVSQQptvtsttSFP...TP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.25|      45|     232|     174|     232|       3
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  174-  232 (65.68/75.65)	PDDNtMDLDHRAASSTQEeelklsalrqniGTAFHLCKSSYtASGPNPSLDLIS.LYGLG
  409-  457 (71.56/48.23)	PDDE.VDLDSGRYSNSEE.........ggrGQGKKKRKKDH.ISGVSPNLSERSgSYGVG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07713 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EVDLDSGRYSNSEEGGRGQGKKKRKKDHISGVSPNLSERSGSYGVGMFG
2) KVMVANDASMAKAAGTVPGSIRQPVHTNGTPSMISTPATEYTRPKRTGKKRSYNDSSFVG
3) MSHAPPPSSVHPGPPSSPSSPAADRTKPHQLYQQNHPKDQTPHTPTSPPLMSVSAQNYASSFSTTRTSPAQTFQFGSLSSPPSSVAMSTQVSQQPTVTSTTSFPTPASSAGGNFVNNLTIDEAEGIAKNGTTDSRKDGESYTGKEVGLDVMDIDTSEHRRTDHDRQKRGADKIPDDNTMDLDHRAASSTQEEELKLS
412
344
1
460
403
197










Molecular Recognition Features






MoRF SequenceStartStop




1) KKKRKKDHISGVS
432
444