<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07706

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDAAEYDTNVFVVNNIASISFRVYEPSSDPPQSFGLAAIEIENTLREQGHIVYYDAARRGIWHFRIVGKEGSDEVSSQELDASLSLRGYSLTIGEEGSFEPSSLPKPRPQQPQTGHTPTSSTSSASALDQTQRHAPTSTSYLGPPGSQEQDSKGYTSSVVDSKSALGGSLSPKAYESFITATLLAVLSAFCSRTGSIPLNYRTILLAQDALGNDGSHDLAAEKVPTIGTFRAYLTTTGVLVICMGVSICHGLLSYGDMLNQAPSIPGQQILAAPFGVIASNQLPTPFEGGTASMAQTPNTQALSLRGAPDIHDSVWKQACLKFLQLRGIAQSKLTDCFWMNLLISRPKLQDAKNDSKRLQMSSSTVTIPWPGPLCFRKRPVEVSSTSRVGATILRGHEESHDPLGNAQSWFSSTSEREEKISKRKAERVATSSEGLNHDSRPSRPNGQSPLTLRRPSTAAAGSMYPTPPDALQNVNGVTPSLDGTLSSPGNPLSAVAVPPEADTNGSTSMAMAESFEPGQDFSEPKRQRSDSNLLGEAEHIFGDMGEDMFGDNDITEADFNFFDEEPEDIDLDAAMEEMSDAAMGANTSTEVPTVEEETPKAAEVLKPQTEIEKDPAVFAKPELRHAVSTQNDHSISRGRDHRPVSMKRESSPFDPQTVFKRVRASLAAAEHVSAITKDTSRMTKIFEKMDFDPTLPMINKKYEQGGQFDYGRDIPTERPRLETGMLPETDYLKRHGKLNRGLKDHRLYSGSLVGPLSGLEPPASGPSPTKLEPQMSEGEQSSAESDPDDSSYTTDEPTSPLKSSVKQAPVEDDAISQVTSLKELDVVEEPDHQLATELPRLSKPDTPELPLSMLFLDPEPLSLELTLSDEDLIQVAQILTEQAATGNLDLCNTGRHSKSCSLASQARPSLLNDARAALQQLREAVPNFLRGVEPVRLKGFLDIQDVLLQGQPRMQPRPIPGRDANAEKMRPSNLYQIPGPHLEVRRSDAKLSVLPSAVTFWESLGLAPSSGNKDITAVCVFPGWKGMVDNAKTFLGRIKSVYEVLRLGSVENMAIASDMDDGVVPYEVDRISTSPDATLTGHGSALVGSMETLRGALSNLTVSDTNIVVYFVYSPNNPGTIVEACAAFQRFFDSYQKDLTLRKEPATNELVLQLVSSDLLSSPTSVVVTSSPDLVKLCMETYDRCTLFGGPMPAPAIRLEQPLPRIIDFRLNTQPSVSLIRENSCIHVAYAQTVDERWVTAAWTDDRGNQQATASYCLGRKGRPLSRSMNEVAHEIWESTLDLISAWKVHWRIIITKCGPMDQQEIEFWIELARTEIKLQVTMILMTVDTNPSLQLIPPVVKLPQASVPFYTTPVSTPQANIVSPEQSATPATPANATAATPGGAEAGVDSETDAVLADVTDQTWGAIVAHRLSNSVSVTDLFPALISGYLIKRTGARVEDVPMAMEVNLIHTESFPRSYEPLLREMLSYFRGLATLSRARGMVPRETDVRPWHIAAAEKAARAMYLLM
Length1510
PositionKinase
OrganismPochonia chlamydosporia 170
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Pochonia.
Aromaticity0.06
Grand average of hydropathy-0.348
Instability index50.57
Isoelectric point5.04
Molecular weight164450.24
Publications
PubMed=27416025

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP07706
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.80|      16|      18|     696|     713|       2
---------------------------------------------------------------------------
  696-  711 (29.93/17.06)	LPMINKKYEQG..GQFDY
  715-  732 (23.86/ 6.91)	IPTERPRLETGmlPETDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1070.27|     340|     624|     278|     646|       3
---------------------------------------------------------------------------
  278-  545 (324.00/257.30)	..................................................................................................................................IASNQLPTPFEG.GTASMAQ....TPN....TQALSLRGAPDIHDsVWKQACLKFLQLRGIAQSKLTDCFWM...NLL.ISRPKLQDAK.....NDSKRLQMSSSTVTIPWPG.PlcFRKRPVeVSSTSRVGAT.ILRGHEESHDPlgNAQSWFSSTSEREEKISKRKAERVATSSEgLNHDSRPSRPN..GQSP.LTLRRPSTAAAGSMyPTPPDALQNVngvtpsldgTLS..........SPGNPLSAVavppeadtngSTSMAMAESF...........EPGQDfsEPKRQRSDSNLLGEAEHIFGDM
  546-  646 (64.03/23.29)	GEDMFGDNDITEADFNFF.DEEPED.IDLDAAMEEMSDAAMGANTS.TEVPTVEEETPKAAEVL....KPQTEIEKDPAVFAKPE.LRHAVSTQNDHSISRGRDHRPVS.............................................................................................................................................................................................................................................................................................................................................
  779- 1171 (445.09/267.47)	GEQSSAESDPDDSSYT.T.DEPTSP.LKSSVKQAPVEDDAISQVTSlKELDVVEEPDHQLATELprlsKPDTPELPLSMLFLDPEpLSLELTLSDEDLIQVA...QILTeqaatgnldlcntgrhskscsLASQARPSLLND.ARAALQQlreaVPNflrgVEPVRLKGFLDIQD.VLLQGQPR.MQPRPI.PGRDANAEKMrpsNLYqIPGPHLEVRR.....SDAK.LSVLPSAVTF.WES....LGLAP..SSGNKDITAVcVFPGWKGMVD...NAKTFLGRIKSVYEVLRLGSVENMAIASD.MDDGVVPYEVDriSTSPdATLTGHGSALVGSM.ETLRGALSNL.........TVSdtnivvyfvySPNNPGTIV..........EACAAFQRFFdsyqkdltlrkEPATN..ELVLQLVSSDLLSSPTSVVVTS
 1172- 1372 (237.15/131.94)	SPDLVKLCMETYDRCTLFgGPMPAPaIRLEQPLPRIIDFRL..NTQ.PSVSLIRENS..CIHVA....YAQT.VDERWVTAAWTD.DRG..NQQATASYCLGRKGRPLS.................................rSMNEVAH....EIW....ESTLDLISAWKVH...WR...IIITKCGPMDQQEIE..FWI...ELA.RTEIKLQVTMilmtvDTNPSLQLIPPVVKLPQASvP..FYTTPV...STPQ..AN.IV.SPEQSATP......................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.68|      11|      23|      67|      77|       4
---------------------------------------------------------------------------
   67-   77 (20.14/13.77)	VGKEGSDEVSS
   93-  103 (21.54/15.40)	IGEEGSFEPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.57|      10|      19|     146|     157|       5
---------------------------------------------------------------------------
  146-  157 (14.13/10.92)	GSqeQDSKGYTS
  168-  177 (18.45/ 7.89)	GS..LSPKAYES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07706 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSFEPSSLPKPRPQQPQTGHTPTSSTSSASALDQTQRHAPTSTSYLGPPGSQEQDSKGYTSS
2) NDITEADFNFFDEEPEDIDLDAAMEEMSDAAMGANTSTEVPTVEEETPKAAEVLKPQTEIEKDPAVFAKPELRHAVSTQNDHSISRGRDHRPVSMKRESSPFDPQTVFK
3) PTLPMINKKYEQGGQFDYGRDIPTERPRLETGMLPETDYLKRHGKLNR
4) QANIVSPEQSATPATPANATAATPGGAEAG
5) SGSLVGPLSGLEPPASGPSPTKLEPQMSEGEQSSAESDPDDSSYTTDEPTSPLKSSVKQAPVEDDAISQVTSLKELDVVEEPDHQLATELPRLSKPDTPELPLSMLF
6) TSRVGATILRGHEESHDPLGNAQSWFSSTSEREEKISKRKAERVATSSEGLNHDSRPSRPNGQSPLTLRRPSTAAAGSMYPTPPDALQNVNGVTPSLDGTLSSPGNPLSAVAVPPEADTNGSTSMAMAESFEPGQDFSEPKRQRSDSNLLGEAEHIFGDMGEDMFG
97
553
694
1360
750
386
158
661
741
1389
856
551










Molecular Recognition Features






MoRF SequenceStartStop




1) DITEADFNFFDEEPEDI
2) GEAEHIFGDMG
3) VFKRVR
554
536
659
570
546
664