Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKYIDSRFERLEKALSNLIDSVTKYHPSTIQAEELKAADSELSKGLEEVQIHQNNYLRIQKLRQSSAALDTQIRDTLTSLANTRKDIVTTHTTTFPSEPNYPIAYEELLRYARRISKTTLPPAATIEGAATPVETQSPNPESQPQSALTPSARTPSQPQSPAINGTPQLASEQPTQQTAVAMNTSLPEGMSQYLNPLSGQLFFPWPLEDKIRSGSLASYQVLVEQGIDPKGYDPATEEERKRKEEEERKAREEQEKAEREAREKQLREERERARAERERQREKELAEWRRASIVSGHPDGPGPSRAGTGLGEKKQFQFTNLDDLDDDDDDD |
Length | 332 |
Position | Middle |
Organism | Pochonia chlamydosporia 170 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Pochonia. |
Aromaticity | 0.05 |
Grand average of hydropathy | -1.056 |
Instability index | 58.25 |
Isoelectric point | 5.02 |
Molecular weight | 37473.83 |
Publications | PubMed=27416025 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP07700 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.10| 14| 15| 248| 261| 1 --------------------------------------------------------------------------- 248- 261 (24.10/11.90) ERKAREEQE..KAERE 264- 279 (20.00/ 8.73) EKQLREEREraRAERE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 51.99| 16| 16| 150| 165| 2 --------------------------------------------------------------------------- 150- 165 (30.48/14.54) TP..SARTPSQPQSPAIN 167- 184 (21.51/ 8.37) TPqlASEQPTQQTAVAMN --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KELAEWRRASIVSGHPD 2) PSRAGTGLGEKKQFQFTNLDDLDDDDD | 284 304 | 300 330 |
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