<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07699

Description RNA polymerase II mediator complex component Srb8
SequenceMSSRTPMGVQPRQPQRGLGSTLQVQRPSNHHQRSISSSQQQYLPTSPVRRDANNGLDANAEPAEALSGRHVSTPRRQGSRLRLELSNELIAAGPPSATESPQTLTPSRMMPLPDPMETDGMSPALSRASQQDSDNPPMPMPKRRLPQASQTVPSTRPAPPPPTPVKKDVRPKPYTVEVPAASPRYANTHRNETTSRDPFSKSLFSGHADFFPWSGNHHEDEWSTEAIQKGTWDRGSQNEASSARIAIFPALKQKTGLNALSTIFMGVLNQRRIRGQITAPSTFKPPPRVTLTDTKREIWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKDVPTERAVWLAKCVGANEIRAFKRKGASGAFVLGGELKWIRDWTVFVEQFVESIVSGFGEPDWKSKVTYAIRLATCLYSEQLLDRDHYLEWIISGLENSPQSRIPMWILIGQIYWADILQSRKCGRRLVFALLNHLNTIENDPDRDILLQLSSQLSTLLVSLLKTNPESFICPPAWQRFGETLRLALPTDDSFAQAAYNVVKQRNTRLLVANTTSPPSGRQYLVQLLDSTLQGQCVSGLSTRCWASADDKPSILKTVVEWATSLHRPGLAKVYVAARLIKSWSIFRVSATSTILDVLGDIPSNDKIRKRLIIRLVGELVRCGHFSVAQYMQWLIGRGGLHDADEIDPVDGPCASRLLVELPVDCLHEEQNSQRGSLLRRAGHYSVGDEANDITSALQYVDGALGLSTYLNDSESPRKALPLKKLLRRIISSSRAVQSAIGSHLYEVVTTQLPHKPDFVMTLAVFSSIRTMMETIEDFSMLSGILKTCSTGPDVDILAACVDTVNAHLDIFVAMDSAETLFDMYIERLKAMSRDQGIIVRSLLASLSSLAARLPQREDLAKQLAQELAQNDRSNAIDACSPVSDSMAAQAQTAEGEVSEQIDKLLASGNVIDHPTMNRLFRYVILRLESGWGKLDDSRRVFSSILSRLRMLDAPHFDKLMADWVSHIRTLKERPSLPELFPLLVSFGCLSMATILHTANASPTNSDSAPDAATSKAATYLQELLQLIIVKLPATASLDSEESYRFQIHQQSAKFEHGKGLLALIRNSLVEYSALQSSARVGTLPLDDVDCQDRLLETMRLLVVADSANVADVLSMNTLPPGATSLAHKIVTRLLLPEADADQNPSFNQILSLANELTIPFCQLKLNLDLSMSLPSASASAGEEGEPSRFEAFAKAMDNAIESQNIMWTSMLPCLSDDITQSLNTEAHTRFLDLMPSSKSESVSTDTTDENRIHLAENLLGVIEAIISGQPPSKSASLTSNLVDKLSELWEIIAVQDEDRAMAKKEVLEHWLPTLLRFITLHSISAEPASIATPGPASSVKPTTTANHEARARIILVLCGLMLEMETLPQELTGSLVQQIFDIAILLVDALPDDLRTQCAKSVLFLSGTTANASTTSDPRMYYLFSTPHPTAAENLKLAHRDKAAMPLTAAVRGMGAMYGIGPMSNERLSPFVLRRWEILSEPTPNVGENDTSLSLGLFEAIKIQ
Length1536
PositionKinase
OrganismPochonia chlamydosporia 170
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Pochonia.
Aromaticity0.06
Grand average of hydropathy-0.204
Instability index47.18
Isoelectric point6.34
Molecular weight169234.31
Publications
PubMed=27416025

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07699
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     180.75|      45|     124|     140|     184|       1
---------------------------------------------------------------------------
   44-   88 (31.70/11.86)	..............PT...SPVRRDAN...NGLDA.NAEPA.ealsgrhvstprrqGSRLRLELSNE
   89-  150 (59.20/28.86)	LIaagpPSATESPQTL...TPSR..MMPLPDPMETDGMSPAlsrasqqdsdnppmpMPKRRLPQASQ
  151-  184 (54.46/25.93)	TV....PSTRPAPPPP...TPVKKDVRPKPYTVEVPAASPR..........................
  278-  307 (35.39/14.13)	TA....PSTF.KPPPRvtlTDTKREIWLK......DLANPA..........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.68|      38|     128|     507|     559|       2
---------------------------------------------------------------------------
  519-  559 (61.84/68.30)	ALPTD.DSFAQAA......YnvvKQRNTRLLV...ANTTSPPSGRQYLVQL
 1032- 1079 (49.84/24.13)	ASPTNsDSAPDAAtskaatY...LQELLQLIIvklPATASLDSEESYRFQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.05|      32|     188|     573|     637|       3
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  606-  637 (55.78/21.32)	YVAARLIKSWSIFRVS..ATSTILDVLG..DIPSND
  954-  989 (48.26/17.52)	YVILRLESGWGKLDDSrrVFSSILSRLRmlDAPHFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.85|      22|     188|     573|     600|       4
---------------------------------------------------------------------------
  578-  600 (34.73/39.44)	ASADDKPSiLKTVVEWATSLHRP
 1170- 1191 (38.13/20.48)	ADADQNPS.FNQILSLANELTIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.31|      45|     287|     795|     875|       8
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  825-  875 (67.40/120.75)	DVDilaaCVDTVNAHLDIFVAMDSAE..TLFDMyiERLK..AMSRDQGIIVRSLL
 1119- 1167 (65.91/35.63)	DVD....CQDRLLETMRLLVVADSANvaDVLSM..NTLPpgATSLAHKIVTRLLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     263.97|      88|      99|    1201|    1297|       9
---------------------------------------------------------------------------
 1201- 1293 (137.47/104.39)	LSMSLPSASAS..AGEEGEPSR.FEAFA.KAMDNAIESQNIM..WtsmLPCLSDDIT.QSLNTEAHTrFLDLMPSSkSESVSTDTTDENRIHLAENLLGV
 1298- 1392 (126.50/73.38)	ISGQPPSKSASltSNLVDKLSElWEIIAvQDEDRAMAKKEVLehW...LPTLLRFITlHSISAEPAS.IATPGPAS.SVKPTTTANHEARARIILVLCGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.35|      42|     322|     395|     446|      10
---------------------------------------------------------------------------
  395-  446 (63.46/67.32)	DWKSKVTYAIRlatclYSEQLLDRDHYLEwiisgLENSPQSRIPMWILIGQI
  720-  761 (68.89/46.06)	DEANDITSALQ.....YVDGALGLSTYLN.....DSESPRKALPLKKLLRRI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07699 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSSRTPMGVQPRQPQRGLGSTLQVQRPSNHHQRSISSSQQQYLPTSPVRRDANNGLDANAEPAEALSGRHVSTPRRQGSRLRLELSNELIAAGPPSATESPQTLTPSRMMPLPDPMETDGMSPALSRASQQDSDNPPMPMPKRRLPQASQTVPSTRPAPPPPTPVKKDVRPKPYTVEVPAASPRYANTHRNETTSRDPFSK
1
201










Molecular Recognition Features






MoRF SequenceStartStop




NANANA