<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07693

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMESSGQNGTRTDHDRDSIMNGVNGANGTPQYANVSKEKASAAATTDGSAKAINGNDGSRPQEPNQNGESSQSRNRMNDLPDEIVHITQGFVPLSLLLTRLAQTSHNALQEKIAELTKMPVPAAAANGSSSYSSSGPDDSSADNLRKKGNLVNFAQEWHGKWLKALVITDWSRKSHLVSKLIDLKFHIDQQRILYDGALDFMVNVKRDLTFARMPSPDLKTALQVLSTGSAPWMPDLGYIEPPALTPETQLKWMNELNTLLSLRLNLEDFDKIPYHFRNYEIASGRVTFRVEGEFEVDLTIADEDFEKQFWFIDFRYAFTPAASSISESLRTHLENCVNDVLGKEGLLGCYQFLHELVLTTKINELKRQALQLSRTSWTGTLNVEPLNRALSIQYWTGRSTTMGSKSWILVAVNSNRTQNGKENASSTSQLVAKWYRDNKEVTEVELELNVNELSAETLLTNVIARHIEHILASIHDKLLTTSRFKNHEASMTLRISKTDPAFSVLTTQVGYNGEASVLLEPMTGAFALKPPSRFTIQPEHQLNNGKSPAEDGLNCLEALRCAILEDELHRRATLMGWFVRKPAMSAEELKSATKVRDWTRAIWLQKDGWGSSWFVVVVLGLNGDEWWLLESNANKSLRFQARIPLNGGYPDLSDFFWQNLAFFTTGVISQSVDLRELHRRQIKCRSSATAKLSLSRKVRLPSTEVELSALFPSMVFDKSKSEEDTTSNNDEQLDHMHLLSLIQRASGAALVRKKAWAENIVHVTFKGIRGFSTLENATDEGPQDGPQEKELICTSEAILRVRRPSKFASLDGLADRDVSYDPSRGEFALRIQRAVGKPILSALKSQIKAIDRFVNFLEALDSAKGTITTESVTLRQITFFYNEPKDHETSAQEEAATEEPPKRWRVVLDLSKDDIDIEIEKGNPHLRVLDLMRQLVNSDGGIGALMAWLPASLPALQAIDKMETEWEPIQASGQGRLVFSMKTIAWMSIEYTINSDEKTLTKPVRLEVKMEPRRCQAWWHVWRSDAESTAQDAISAALQPIWNKKGDNWLGLSTGAAGRPHGGVVKMLLAVDEAIRGTVTNESSGTQDTDVVVLD
Length1095
PositionTail
OrganismPochonia chlamydosporia 170
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Pochonia.
Aromaticity0.07
Grand average of hydropathy-0.398
Instability index42.05
Isoelectric point5.86
Molecular weight122347.81
Publications
PubMed=27416025

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07693
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.07|      26|     100|     697|     722|       1
---------------------------------------------------------------------------
  697-  722 (44.14/24.14)	KVRLPSTEVELSALFPSMV.FDKSKSE
  800-  826 (41.94/22.63)	RVRRPSKFASLDGLADRDVsYDPSRGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.54|      55|     108|     510|     571|       2
---------------------------------------------------------------------------
  510-  571 (84.74/65.60)	GYNGEASVLLEpmTGAfalKPPSRFtiQPEHQLNNGKSPAEDGL.NCLEALRCAILED.....ELHRR
  620-  680 (90.81/51.29)	GLNGDEWWLLE..SNA...NKSLRF..QARIPLNGGYPDLSDFFwQNLAFFTTGVISQsvdlrELHRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.91|      32|      98|      25|      62|       4
---------------------------------------------------------------------------
   25-   62 (46.28/54.34)	ANGTPQYANVSKEKASAaattDGSAKaiNGNDGSRPQE
  125-  156 (55.63/44.17)	ANGSSSYSSSGPDDSSA....DNLRK..KGNLVNFAQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.01|      26|     205|     384|     412|       5
---------------------------------------------------------------------------
  384-  411 (39.86/31.54)	EPLNRALSIQYWTgRSTTM.....GSkSWILVA
  587-  617 (42.15/22.83)	EELKSATKVRDWT.RAIWLqkdgwGS.SWFVVV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07693 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MESSGQNGTRTDHDRDSIMNGVNGANGTPQYANVSKEKASAAATTDGSAKAINGNDGSRPQEPNQNGESSQSRNRMNDLPDEI
1
83










Molecular Recognition Features






MoRF SequenceStartStop




NANANA