<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07692

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDQTSRPRRAVRESMDYWSRFVDKCISKRLSTEDFDEFVRLIQAKHPLPPFLIAFLFLRPMPDNDVSLDPRIPPYIQVLSRLGYIDAPSILKVLYKFSSLHTQLKASTQNGTQSESKDNKDSHDSNGKDKKQSPRRWRSSSWAEEVMFYHVIKTIVEGTAFRDSRAVLELVQVISKWMELFTSVSSAFATDVMGELQNSQARDDMDVARAAFVPLLLRLVEVPALVKAISNPNVKAIRQQLSNSLAGFIHTLQPAPGFVERLDIFRTETLDRLDPIDKRSQAAANAAMDELLETTVGVDNFAIPDLLITNTRSALYVYLNATLVGRPLIDDNVLISYLQNRYQGATQPSAIELIIASFDILANAVFRNEGPRDAHLLKSFLVNKVPLLLCHLFSHEPTFDTNSTEYCITAALNQVDTSVFPTASLMFDESRSNNPYTESVREDFCTACALHGLVQREHVERILGETSMSYEPSLEKYSKEKLVQDCLADAEKVQGLIRELEKMDGNVGAVCQALVEVMRQLCNNKETMSLKLLCSQLAQKPQTLDILLLFEKLPTILDPLCQLLDNWRYEEDQGEYQPIYEEFGSILLLVLAFAYRYNLTAADIGIMSPDSSIAKILSRAHISRERDELTEQEKGHMSGWIHGLFDTESGGLGDDLMSSCPPQDFYLLVASLFQNIVVAYTYGYLNDETLKGGVEYLVDTFLLPSLVPALRFLADYLWVEQKEQKAVIKVLQLILLPSSISGEASTMLSSVRNLVAKPLEHSLRTYQRQDPKNQDIEPLLRALKDSLPLSRRTGGADHNELESWTNASSNGLAGALRHTVQGLFQWSFHQATGNSLPTSYTHRQLIAAVKIMGAKRALRLLLDEVRTHSEAGTGPLVYDVVGAMICAPNVTNELPPNSQMMDPAGNLPPAIQQPLTLREALRFEAESCRKLQKTDPVLAEVVVRLHRRVEAHLVMPQAQGMLEAPGIQLDLTAGPGGLGDVGAMAAAAGVGGDGMGVDGLDMGMGGPGSAGGLDTTSDGDLFGGLDTSDMDMFAWGDSMDLSGN
Length1044
PositionTail
OrganismPochonia chlamydosporia 170
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Pochonia.
Aromaticity0.07
Grand average of hydropathy-0.150
Instability index41.95
Isoelectric point5.09
Molecular weight115593.53
Publications
PubMed=27416025

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07692
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     257.84|      87|     209|     704|     839|       1
---------------------------------------------------------------------------
  162-  253 (135.91/93.49)	RDSRAVLELVQVI.......SKWMELFTSVSSAFATDVMGELQNSQARD..DMDVAraafvPLLLRLVEVPALVK...AISNPNVKAIRQQLSNSLAGFI.HTLQ
  722-  821 (121.93/173.39)	KEQKAVIKVLQLIllpssisGEASTMLSSVRNLVAKPLEHSLRTYQRQDpkNQDIE.....PLLRALKDSLPLSRrtgGADHNELESWTNASSNGLAGALrHTVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.09|      25|      27|     976|    1002|       2
---------------------------------------------------------------------------
  976- 1002 (40.48/26.89)	GGLGDVGAMAAAAgvGGDGM.GVDGLDM
 1005- 1030 (39.61/20.24)	GGPGSAGGLDTTS..DGDLFgGLDTSDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.17|      20|      27|     549|     570|       4
---------------------------------------------------------------------------
  549-  570 (32.52/24.82)	LFEKLPTILdpLCQLLDNWRYE
  579-  598 (34.65/19.32)	IYEEFGSIL..LLVLAFAYRYN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.78|      35|      36|     430|     465|       5
---------------------------------------------------------------------------
  394-  422 (41.70/26.92)	..SHEP....TF.DTNSTEYCITAA..LN...QVD..TSVFPT
  430-  465 (57.11/45.37)	SRSNNP....YT.ESVREDFCTACA..LHGLVQREhVERILGE
  467-  506 (41.96/27.13)	SMSYEPslekYSkEKLVQD.CLADAekVQGLI.RE.LEKMDGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.30|      19|      32|     650|     668|       8
---------------------------------------------------------------------------
  650-  668 (36.64/22.87)	GGLGDDLMSSCPPQ..DFYLL
  683-  703 (28.66/16.25)	GYLNDETLKGGVEYlvDTFLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07692 with Med5 domain of Kingdom Fungi
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