<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07686

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTVSSWLTLARQCLLRRVSVQRFGDFLRSHDSEIDGKRLFGALVECRESFCQPGDPLISLYIDHIVVTGIIAISDGLIILTRRWNDTKFPASQNTLACYNDTLQDLTMIIVSPKYKAGACEARLALQISSRWLCSLARQASRGDPGPSELELNNTIEFLAFLMASMAATDAGFEALSPPESQGVKVKHGSVYDLRTSVKQAFELCLPLYSMLSSQLMERINTVLKHINLLDEGASQAGNATAPTSEIQALQFQVSIADSQLVASKAGTILYLEGLLFTGSTIDDGGTEGEAQPVYDDFGAIFLLILVSRGRLGLSKSSLGIRKKDGFLAQYLEHENSEESLESLSDEQKSHLGNWINALYLAEGLSDELFTNCSPHDFYPLIPTLLRQSMTAHQQGKLTHDSLQAGLDYLLEPFLLPSLISAMNWVAEVIQHERMVAGKVLETLMKPRESLESRDIHHTILTLCAPRLKMHLKAITSQDTNVDSILRILDECPDFSFFSERERQNPGPGILNILQHSLVTLITSTVALDIGDTAPFTDISAIVNRAVEVRGPHTTLRAIVGVLLQLSDNHAFLYALDTLTTVVCMAGNGLRDALRLQYHDLGSLLKSGETLTAEGVVRLHRQVETYTNLLAVPEMGLDSFNFTQQLTNIDTTNANLDSGTAVSGGMDIQTEQGQADGIDQVLDEVAAMGNLDSNDADMSFDALYDLQGNDMDLNDLDLDMF
Length721
PositionTail
OrganismFonsecaea erecta
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Fonsecaea.
Aromaticity0.06
Grand average of hydropathy-0.026
Instability index43.61
Isoelectric point4.71
Molecular weight79150.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07686
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.97|      43|     119|     413|     487|       1
---------------------------------------------------------------------------
  441-  483 (74.44/81.51)	LETLMKPRESLESRDI...HHTILT....LCAPRLKMHLKAITSQDTNVD
  601-  650 (61.53/20.28)	LGSLLKSGETLTAEGVvrlHRQVETytnlLAVPEMGLDSFNFTQQLTNID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.22|      16|     207|      60|      76|       4
---------------------------------------------------------------------------
   60-   76 (24.30/21.33)	LYIDHIVVTGiIAISDG
  270-  285 (28.92/19.98)	LYLEGLLFTG.STIDDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.13|      25|     119|     413|     438|       5
---------------------------------------------------------------------------
  380-  406 (35.00/21.79)	P.LIPTLLrQSMTAHQQgKLTHDSLQAG
  413-  438 (40.13/31.59)	PfLLPSLI.SAMNWVAE.VIQHERMVAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.43|      61|     360|     135|     198|       6
---------------------------------------------------------------------------
  135-  198 (95.28/81.18)	SLARQASRGDPGPSelELNNTIEFLAFLMASMAATDAG....FEALSPPESQGVKVKhGSVYDLRTSV
  496-  560 (98.15/71.49)	SFFSERERQNPGPG..ILNILQHSLVTLITSTVALDIGdtapFTDISAIVNRAVEVR.GPHTTLRAIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.49|      17|      27|     329|     345|       7
---------------------------------------------------------------------------
  329-  345 (28.18/19.04)	AQYLEHENSEESLESLS
  358-  374 (29.31/20.11)	ALYLAEGLSDELFTNCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.19|      11|      23|     656|     667|       8
---------------------------------------------------------------------------
  656-  667 (15.83/13.30)	LDSGTAVsGGMD
  682-  692 (19.36/10.97)	LDEVAAM.GNLD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07686 with Med5 domain of Kingdom Fungi
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