Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MAELTTDQVRSLDQTRQRLLALHKSLVALGSELVTQNPLPSWPALQLHANLVSNNLQTIVSQLAEHRDTYQSTVAFPTPKFPGTQRAFILETLLRTKLEPNVEDWVEEGENISAQKHKATFRGLSDNDRHALWQWAPGAANGAARKQKWGADFTLEEKQKGIENVATGLRRQLQEPPDEEGEEGPEEEDEYDITDEEDEDEDADKMDVEKQPPKTEASPASADTRAALPTAGQMNLATLHKFMSTGR |
Length | 247 |
Position | Head |
Organism | Fonsecaea erecta |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Fonsecaea. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.819 |
Instability index | 57.11 |
Isoelectric point | 4.73 |
Molecular weight | 27577.14 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP07684 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 61.41| 18| 29| 104| 121| 2 --------------------------------------------------------------------------- 104- 121 (32.99/25.56) DWVEEGENISAQKHK..ATF 134- 153 (28.42/20.97) QWAPGAANGAARKQKwgADF --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ADKMDVEKQPPK 2) EDEYDITDEE 3) RAALPTAGQMNLATLHKFMSTG | 203 188 225 | 214 197 246 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab