<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07682

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNTSLEFPNNCSTNIYTLPDFGEIAYIVCTVATPPTQDPAVFANTKENTLARLRKTERQFREASILAALDVEARQLFTFYKKVDITAPRDQKTLLLKFGYVLRANTCTIAYKTAARLPDLLKPEQARLYRLFITAIVSSIKFTPIGEAELQPLGPNLYLVEQAPSATDIHHFDKIKRWLLYRIDLQVIPGGQIILTIAKDGAFSFFRVRDGAMKLNWSGHANSEATAIYLAPIGRIGRTRRSKILTHKKLNGTSGNQPSDENQLSNAQREVWRELLPSWLKEHRNTSIEAMEDDWVEVEVPIEEIDHASNDSQPDDTSPNNVNYDSVTWRTIFWPAHLCFIFSNEEPAAVTQTKGEQDPMQFVRDWILGTGGGTSKVETGRQNLMDEDDEPLFADEGTFDDPVHFHPFGPPGFGPGQTIYPTPPDVGMTHPTPGFSSVDGMAMTPANPPRGPVERPQPQDEDMPDFEDEPTTSGLQTFYDEDLFEENPDDNLGAEANGDEPNWDFFDRPGIDPNSARSVSHGRSEETAVRGEIQPGMMRANDEVTGQDAASQGPTVVQGESMGPDAAPRAPANAELLQLQDQMEQPTMDTEVKGKQILQPPPQRGPPPLWQPEFAPEQTIGADRGRRSSVYDGLRSLPSVSSHDSRYGAGGDYWFDPTPILNKKGSSKPNPVFQRPASSSSDSDSLMTSSSNSPERASWQNATHVPFRQWTEYRSPSPNAANRQSEIDKKTFYQDVQQILGGLRSGLVDPPTLSDFQLDDPRPRRIPPVSPQKFLQIAHVLVEQMSQTTLLPRGELEREIQVPPRDQMDVNVDLSGINTSAVPSSVFQLTNPKTEPNNGGIPGRVTRIQPDQIRIRRMERPLTASMAILSFWDSLNLQPESGPKDVTAFCIHPSQENVTEGCFSLLQRLTETYTSCSLGTHTVGRLPGMTDTGLISWSPNDTGQHNLLQRCHKVGSALAEASDVKGTILICMIARNQSAISYLEACIGFFSLFESFTEARTDNQGVTDIALQVIPQSFVADAEALVIPSQTAYIRLAIEVYNRLPPSELPAPPAACSSAVVLSKSENSVHLQLTPTYGSPLEKNGPCLHLAYSVSHDNRWLTAAWTDESGRVALSMSYCLRISQSGKSRPRHDIFREMWDVSQDLMSKVRGPWRLAVVKHEYYEQPELLDWHQLFENAPTSQKRCLLVLLSVQLDPTLEIFPPANQGKSAQTGAQNLYGTPASTPQGSMTSPEQTVPATPTPGGSSFMNAPTPSDPGFDPNSESDLILLDPSEESWGVILPYGVNQARSLVQLRPSQVTGYLIKRRGTKWEDGYSMIEFSLVTSTIHISNTSSETSPDELLEDLIKQYRGLVTLGATRGCVDPNSECLPWHIATAIRGAQLLGQTL
Length1386
PositionKinase
OrganismFonsecaea erecta
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Fonsecaea.
Aromaticity0.08
Grand average of hydropathy-0.485
Instability index52.33
Isoelectric point4.99
Molecular weight153283.89
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07682
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.71|      30|      39|     614|     645|       1
---------------------------------------------------------------------------
  614-  645 (45.23/30.30)	FAPEQTIGADRG..........RRSSVYDglRSL.PSVSSHDS
  655-  685 (42.36/22.13)	FDPTPILN.KKG........ssKPNPVFQ..RPA.SSSSDSDS
  686-  725 (34.13/16.24)	LMTSSSNSPERAswqnathvpfRQWTEY...RSPsPNAANRQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.51|      32|      40|     431|     470|       2
---------------------------------------------------------------------------
  381-  422 (30.54/10.09)	.......RQNLMDED.....DEPlfadegtfddpvhfhPfgPPGFGP..GQTIYP.T
  423-  447 (31.35/18.47)	PPDVGMT..............................hP..TPGFSSvdGMAMTPaN
  448-  470 (22.62/14.76)	PPRGPVERPQPQDEDmpdfeDEP..................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.67|      16|      40|     835|     852|       3
---------------------------------------------------------------------------
  835-  852 (27.26/20.30)	EPNNGgiPGRVTR..IQPDQ
  878-  895 (26.42/12.91)	QPESG..PKDVTAfcIHPSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     202.35|      50|     432|     744|     804|       4
---------------------------------------------------------------------------
  744-  795 (84.71/39.68)	RSGLV...DPPTLSDFQLDDPRPRRIPPVSPQKFLQI.AHVLVE.QMSQTTllPRGE
 1193- 1228 (46.97/16.70)	................QL.DPTLEIFPPANQGKSAQTgAQNLYG.TPAST...PQGS
 1251- 1301 (70.67/35.45)	PTPSDpgfDPNSESDLILLDPSEESWGVILPYGVNQ..ARSLVQlRPSQVT....GY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      88.98|      17|      39|     548|     564|       5
---------------------------------------------------------------------------
  526-  547 (17.37/ 6.39)	ETAVRGeiqPGMMR....AndEVT.GQ
  548-  564 (28.60/16.35)	DAASQG...PTVVQ....G..ESM.GP
  565-  585 (20.07/ 8.78)	DAAPRA...PANAEllqlQ..DQM.EQ
  589-  606 (22.95/11.34)	DTEVKG...KQILQ....P..PPQrGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07682 with Med13 domain of Kingdom Fungi
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