<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07681

Description Mediator of RNA polymerase II transcription subunit 18
SequenceMHEFALYGQVRKDDHHRMLQQLAGFARMQPQDAKEIHLVFKARQPPGVDLVQSIGASHLASQSQQDNIQRVKNMLNAGLYYVQLVGEVSPGTRAGVSENGDVTMTDVNGGQGAEKSSVKWSFEFKDTPDAGKQAVSSRLISRTPMEDGNFVQFLDHFGYDYVSRYIVVGSRFYDHDTTLFLHKVLRLPQIAADQAISDESFLSKLDHLPDVDGSGGYILQASIDVVDGNNPELKERATRQLLAIKEALRQAVDLSPGDRLALDTRLPITSRRA
Length273
PositionHead
OrganismFonsecaea erecta
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Fonsecaea.
Aromaticity0.07
Grand average of hydropathy-0.410
Instability index38.08
Isoelectric point5.98
Molecular weight30307.71
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07681
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.29|      11|      19|     180|     190|       1
---------------------------------------------------------------------------
  180-  190 (20.13/14.59)	FLHKVLRLPQI
  201-  211 (20.16/14.62)	FLSKLDHLPDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.10|      14|      15|       1|      14|       2
---------------------------------------------------------------------------
    1-   14 (24.27/13.90)	MHEFALYGQVRKDD
   19-   32 (23.83/13.54)	LQQLAGFARMQPQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.04|      14|      19|      37|      54|       3
---------------------------------------------------------------------------
   37-   54 (17.88/20.45)	HLVFKARQppgvDLVQSI
   58-   71 (24.15/13.61)	HLASQSQQ....DNIQRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.05|      18|      27|     219|     236|       4
---------------------------------------------------------------------------
  219-  236 (29.64/16.79)	LQASIDVVDGNNPELKER
  248-  265 (29.41/16.61)	LRQAVDLSPGDRLALDTR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07681 with Med18 domain of Kingdom Fungi
Unable to open file!