<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07678

Description Uncharacterized protein
SequenceMTSISPAEARPPPLRRPIDSKRPAPGRTSSHVFSPTDKKVPAPQRETIDAGEDRPVKRRKIETSPNSNQTSNHSVTSFPARVSDSHVDTKTVAWRWLKPSAVRATIANSRRGEEEENSSEDEVPELPPRPWRTIRVAKASDKPTPTHRLRVDVPVPNTPDSIQVPSSAPQFVPKKPVGFFPWTGKHPEDILNDNNVKNGYFDKPPNPTEKELNTARVSLYNAFKHKSGVDSLSALFSLVLNQKSQHGLISSASAFKPPPRVTLTEAKRKSWIADLANADVPLRRLSRTIPQGIKGQILLEQCLQSSVPSSRAIWFAKCVCANEIRTLRRKGTAPAVAVGAENKWLREWTQNVEQFLETYLGQANSPDWKSNVLYALRLNTRLYLENLLDRGHYLDWILRSFNAADVGHTPFWLMVIHIYKQDLSHYRRRGARLAKALIDKYRSVDKLPDQTITPLKQRLRAAIRELLFARPAIFLMPDRWPESVPIVRTCLDTTIGTEGQILEELNRINERAMGFNKAEFLSVRAADEAIVETLDAAKVPYNFALLEEDLAEACSDFDLLLRSCLEWSCTRFRQSTTRVYLVTRLVKRWQRDGCDVDTPILNFLSSFREGKTTADIRSLRHLIAQFSRSDCFPLSKYIQWLMVRGLPEKGTVRIDTNSIFGRATGADSPKGPESIQFLLDLSLHRAEDHVINLRNSVLERAGFDANSEEVIFRQCVRFLEQKLADSSFFTKPEPSALPEPSFASLPWTLRTRISMWLRSRALEAAKSAQSTPMLPGSKVLNDEQFFVIRHVLECMEDEAVLADVVGILSVSQRDDLVASLVATIHFHAGTFSAIGALEILQKRMCQVYMNWRPAKPTMPLLTTTLLDLCTAFPVKTPAIRLLQQDLVRGDRGRAVAACSPYSDGIAESLQQAGATFVEDFEAILQSETNMNEQTMNGLFSVLVDRIERQQKFADDTQTLHSFCQLLSRLRLCRRVQGDLLIQKWMSRLIPRLDLKSGPLLLRILIATGCITFGTIFEAMTSSKSGPRKNLALASLLYQILAPAHSTSLDWATYQTRIRWYEYSQRNPSTALEMLCEAGLQGVSPSFDSLLLAVLVNSWTSDSSLPDSAKRWFVKSLSWTLRCSDGDLNVAGLQALLESISVFSHRFVQLRFRLTPPTSFEKASGPDQPDLIQVLSQSLKQSLRKQPSTYGQQQRFSQLFQIVGSDVASQVRQNIENEFLDALPKLPIGKVTSPISAIFPGDAQQLSSIVEQAFQVCRKDISPSPGFMSHLIDRLSQYVKCLGGVQMTPGTPAASATSAPSGVSGHGGSSTSINPSQMLSMTSSPIASTSDVGGGSFPPACLSYLRYMLQMVCLQRPTLVLSGSSAPNAKQVQNEQFQLLVRLASIATHPAMTLASGHPGNLDEQVKAKEVVDFAFDVIATIIDGVTDEVKMMCAKFLKDKLQDARLGYLFGSINILGSTQVQDVGRGLQMAKEGKGVIGEWKPRMWEVLDNGSGKESETSLGLGLFRARYV
Length1511
PositionKinase
OrganismFonsecaea erecta
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Fonsecaea.
Aromaticity0.07
Grand average of hydropathy-0.248
Instability index51.00
Isoelectric point9.10
Molecular weight168285.73
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07678
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     218.11|      73|     226|     643|     725|       1
---------------------------------------------------------------------------
  643-  725 (103.48/86.90)	VRgLPEKGTVRIDTnsifGRATGADSPKGpESIQflldLSLHRAEDHVINLRNSVLE.RAGFDANSEEVIFRQCVRFLE..QKLAD
  879-  954 (114.62/68.05)	IR.LLQQDLVRGDR....GRAVAACSPYS.DGIA....ESLQQAGATFVEDFEAILQsETNMNEQTMNGLFSVLVDRIErqQKFAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.98|      36|     243|       4|      51|       2
---------------------------------------------------------------------------
   10-   47 (58.87/43.85)	RPPPlRRPIDSKrPAPGRTSSHVFSPTDKKVPAPQRET
   54-   89 (62.10/35.81)	RPVK.RRKIETS.PNSNQTSNHSVTSFPARVSDSHVDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.87|      14|      26|     355|     368|       3
---------------------------------------------------------------------------
  355-  368 (27.31/19.15)	FLETYLGQANSPDW
  383-  396 (27.55/19.39)	YLENLLDRGHYLDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     163.12|      43|     203|     280|     327|       4
---------------------------------------------------------------------------
  280-  323 (71.83/42.20)	VP..LRR..LSRTIPQGIKG.QIL..LEQCLQSSVPSSRAiWFAKCVCANE
  484-  528 (56.41/27.47)	VP..IVRtcLDTTI..GTEG.QILeeLNRINERAMGFNKA.EFLSVRAADE
  539-  573 (34.88/16.80)	VPynFAL..LEEDLAEACSDfDLL..LRSCLEWSCTRFR............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     275.73|      87|     293|     955|    1047|       5
---------------------------------------------------------------------------
  955- 1047 (135.00/114.17)	DTQTLHSFCQllSRLRLCRRvqgDLL.IQKWMSRLIPRLDlKSGPLLLRILIATGC.ITFGTIFEAMTSSKSGPRKNLALASLLYQILAPAHSTS
 1241- 1329 (140.73/99.67)	DAQQLSSIVE..QAFQVCRK...DISpSPGFMSHLIDRLS.QYVKCLGGVQMTPGTpAASATSAPSGVSGHGGSSTSINPSQMLSMTSSPIASTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.74|      18|      26|     127|     145|       6
---------------------------------------------------------------------------
  127-  145 (28.35/22.10)	PPRPwRTIRVAKASDKPTP
  156-  173 (33.39/19.48)	PNTP.DSIQVPSSAPQFVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.99|      16|     365|     735|     750|       9
---------------------------------------------------------------------------
  735-  750 (33.74/15.81)	SALPEPS...FA.SLPWTLR
 1102- 1121 (21.25/ 7.53)	SSLPDSAkrwFVkSLSWTLR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07678 with Med12 domain of Kingdom Fungi
Unable to open file!