<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07677

Description Mediator of RNA polymerase II transcription subunit 10
SequenceMAPYKALTPQRGVAPAVRASSHANPPSTPSGRDQDHRAGTPQGTGTASGSGAGTPTGRAGRAGNRFQNDATQRVVRHKKTPYVYRIGIRLPREKLRQFPRYNGKVGKFLSEGAGAGSFVTLKVPGLHTILNSRPRQFPSTSALESADTVATAVSAAAFAPSPGTIPSGAPSIFSEVEPLSDSRTPVTNASSPQETCLDYGLRDLWRGAEEELPAATSGSSIAHDQYRPVPEESKHSTTPGTLDQSYVFPDRTGPDFEDRPVAERLLRNPDTDDDAMAPVKDTSNVHNTIKDIIQHLTDIQIQTHGYIPDTQDLLVDKLTDLTNSLSQLKHLTSPTESPNNYIHQVAIAPEIVDYVDDGRNPDIFTRDFVENVQRGNAVINGKQQAFREFTEIFAEKLKEGIPGVSKEVDRVLRNAGFDEQHDSTANGDEQAASQAGDSNPNGPANG
Length446
PositionMiddle
OrganismFonsecaea erecta
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Fonsecaea.
Aromaticity0.06
Grand average of hydropathy-0.681
Instability index33.27
Isoelectric point5.68
Molecular weight48046.25
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364146

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07677
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.89|      32|      36|     281|     316|       1
---------------------------------------------------------------------------
  269-  307 (47.58/39.88)	PDTDDDAMApvkDTSNVHNTIKdiiqHLTDIQIQTHGYI
  308-  342 (51.31/32.96)	PDTQDLLVDkltDLTNSLSQLK....HLTSPTESPNNYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.70|      17|      23|      28|      46|       2
---------------------------------------------------------------------------
   28-   46 (29.40/20.98)	TPSGRDQdhRAGTP.QGTGT
   54-   71 (27.30/12.85)	TPTGRAG..RAGNRfQNDAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.91|      13|      18|     414|     427|       3
---------------------------------------------------------------------------
  414-  427 (20.16/11.28)	NAGfDEQHDSTANG
  434-  446 (25.76/10.55)	QAG.DSNPNGPANG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.66|      12|      27|     364|     375|       4
---------------------------------------------------------------------------
  364-  375 (21.98/16.24)	FTRDFVENVQRG
  389-  400 (20.68/14.86)	FTEIFAEKLKEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.42|      33|      37|     118|     154|       5
---------------------------------------------------------------------------
  118-  154 (47.43/38.82)	FVTlkVPGlhTILNSRPRQFPSTSAL.ESADTVATAVS
  158-  191 (51.98/30.23)	FAP..SPG..TIPSGAPSIFSEVEPLsDSRTPVTNASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.63|      15|      18|     202|     216|       6
---------------------------------------------------------------------------
  202-  216 (26.77/14.27)	RDLWRGAEEELPAAT
  223-  237 (27.86/15.10)	HDQYRPVPEESKHST
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07677 with Med10 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AEEELPAATSGSSIAHDQYRPVPEESKHSTTPGTLDQSYVFPDRTGPDFEDRPVAERLLRNPDTDDDAMAPVKDTSN
2) MAPYKALTPQRGVAPAVRASSHANPPSTPSGRDQDHRAGTPQGTGTASGSGAGTPTGRAGRAGNRFQNDATQRVV
3) VDRVLRNAGFDEQHDSTANGDEQAASQAGDSNPNGPANG
208
1
408
284
75
446










Molecular Recognition Features






MoRF SequenceStartStop




1) DYGLRDLWR
2) HKKTPYVYRIGIRLP
3) MAPYKALTPQRGVAPAVR
4) VFPDR
198
77
1
247
206
91
18
251