<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07676

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMADDLDHHRDKRQRVDSDRDQEAEHMEVEPLREATNHDRNDEMDVDRGPTAQGKRAGPGENEQAARLMVDEKTLEQLQKDMGEAFLLCRSKVERQRPNPQQHLLALYGLGPLLHSVARTDPRTGEKINKLRKSYEGQIKGFALAGRNKPVKGERNVEEDQPGPLRRMAGSSPWGLQPNEQWNAEHAKSSIEVTPDFRAKLKQAMQMQPGTVRNNAHWEDMLGFDKPKPGVAPAQQQPPSIPRPVANGVLRQAHQPSAEAKRQTRGKKRSYGDDSFVGYGEGYSDPEDGDGDEYGSQRKRKKVTVTDY
Length307
PositionHead
OrganismFonsecaea erecta
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Fonsecaea.
Aromaticity0.05
Grand average of hydropathy-1.230
Instability index40.15
Isoelectric point7.15
Molecular weight34599.02
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07676
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.96|      13|      46|     160|     177|       1
---------------------------------------------------------------------------
  160-  177 (23.37/19.31)	QPGPlrrmaGSSPWGLQP
  225-  237 (24.59/10.30)	KPKP.....GVAPAQQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.95|      11|      17|      12|      22|       4
---------------------------------------------------------------------------
   12-   22 (19.20/10.23)	RQRVDSDRDQE
   32-   42 (19.75/10.71)	REATNHDRNDE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07676 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FLLCRSKVERQRPNPQQHLLALYGLGPLLHSVARTDPRTGEKINKLR
2) GFALAGRNKPVKGERNVEEDQPGPLRRMAGSSPWGLQPNEQWNAEHAKSSIEVTPDFRAKLKQAMQMQPGTVRNNAHWEDMLGFDKPKPGVAPAQQQPPSIPRPVANGVLRQAHQPSAEAKRQTRGKKRSYGDDSFVGYGEGYSDPEDGDGDEYGSQRKRKKVTVTDY
3) MADDLDHHRDKRQRVDSDRDQEAEHMEVEPLREATNHDRNDEMDVDRGPTAQGKRAGPGENEQAARLMVDEKTLEQ
85
140
1
131
307
76










Molecular Recognition Features






MoRF SequenceStartStop




1) DGDEYGSQRKRKKVTVTDY
2) DSFVGYGEGYSD
289
273
307
284