<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07673

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNGERPAANGEQIANGFQQTVADSTPESGQLKTESVPSNPPPPSIDNTRNCANGDVESSQQPSDNKGSDVAHLHEQAPSDILHLISQDSYLPMAALINRASQSCWNGLSDLVTHLASMPVPELPPDQAKLLPTGLPNNQSKANLEKKDRLLKFSNDQKADFIKLLVLLQWSKNVDEVSKTISINYWLMQRREAYWNAIGSMALLKQESSGFQIPNPDLKTAAEVLSRGTVLSLPRLGYTPQKDLSSRQILRILQSLNRVLSVKLALWDDLPPQLRRYRIHDGRATFTVPNEFELDVSILGDSQDSPFRMVDFRFSFQPSPHIPDSLHSEIELYANSNIDRDGLQGCYDFLHELALSYKLAELHKQAVDLARNQWAGNLRVELIRRNLVVQYWPERQLGKSWIEVGIASGREKQKITKTDSPPFLEVKWMRQGKRVDSLQLHLNDALLSFEAILRQVIAQHITQILDNIYDKLILTPLFANVELFLEQSLSYEDPEECFLTMQLSRSSDLQLKIDSVTGFLVLSPVTERTERLQYEVNRVQGVADDVVSKLLNYRCSIMESRVLVGILGTSWEGLRSFKLSQAEARALFGGPVSRMNMFRQNQWTMAYTLAITHAPDGDHWWLLQQVAAGALSHQTRYRVLHKQRIEVKEELSSAYFDRLAEYLMGLIFLERNADFFRERKEKFDLRPLPAFDQHYELPEISFDLDMARPAFSKQPVPPTAFGSATALQTANSAPNPPALQKGIKVRFGGVDRSTNKVRAVAQYHYQTSSAVLRRIEQSVLDACVSLNPEDKTVMIRVTTAIAQAAIPEIVDKAMDVEKVVSTVEQIHRLPGLRLNAISNSSFTIAYHEGAPAELELRIGFPSGNQAPQLDFFPAGENPHQFLAAQYTKLIAASRGPFATRIRDFLTSLTLTLPLLTYLHKLQDKHGLNPETQQQTDPPGQEDHLRVHILVRSATAFAIQYFTPAGQAPKDVKADSQPHMLARLEVLHHINMSRKPMWLVRAALEDFQSYSRPAYSTPELGAKLKQEIFTRPDGQSKWLALDKAAACMADQPEPLLQAMHDLLWEWAKLAKASEGKVPINLPLNKAKAVPGNPNANNANLPNGPNSRLPAPMKAPPGKMQAPGGMIPNGANVKVQRPSGTGPGGRPMPPNHKANTNSAQKQEVIMLD
Length1166
PositionTail
OrganismFonsecaea erecta
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Fonsecaea.
Aromaticity0.07
Grand average of hydropathy-0.379
Instability index53.99
Isoelectric point7.42
Molecular weight130386.12
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07673
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.59|      15|      18|     683|     698|       1
---------------------------------------------------------------------------
  683-  698 (25.61/20.29)	FDL.RPLPAFDQHyELP
  702-  717 (24.99/13.70)	FDLdMARPAFSKQ.PVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.44|      42|      88|     849|     891|       2
---------------------------------------------------------------------------
  849-  891 (70.20/42.26)	GAPAELELRIGFPSGNqAPQLDFF.PAGENPHQFLAAQYTKLIA
  939-  981 (69.24/37.63)	GQEDHLRVHILVRSAT.AFAIQYFtPAGQAPKDVKADSQPHMLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.09|      24|      88|      30|      53|       3
---------------------------------------------------------------------------
   30-   53 (44.45/21.74)	QLKTESVPSNPP......PPSIDNTRNCAN
  114-  143 (38.69/17.94)	HLASMPVPELPPdqakllPTGLPNNQSKAN
 1084- 1101 (25.95/ 9.50)	..KAKAVPGNPN......A....NNANLPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.96|      16|      18|     216|     231|       4
---------------------------------------------------------------------------
  216-  231 (25.94/17.84)	PDL.KTAAEVLSRGTVL
  234-  250 (24.02/15.90)	PRLgYTPQKDLSSRQIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.80|      15|      19|     774|     791|       5
---------------------------------------------------------------------------
  774-  791 (21.60/21.93)	RIEQSVLDACVslnPE..DK
  796-  812 (20.20/11.13)	RVTTAIAQAAI...PEivDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     202.88|      52|     288|     302|     396|       7
---------------------------------------------------------------------------
   76-  113 (45.81/ 8.44)	QAPSDILHLISQdSYlPMAALINRA...SQSCWNG.LS.DLVT...........
  344-  395 (91.91/105.61)	QGCYDFLHELAL.SY.KLAELHKQAVDLARNQWAGNLRVELIRRNLVVQYWPER
  484-  528 (65.16/20.85)	.....FL.EQSL.SY.EDPEECFLTMQLSRSS.DLQLKIDSVTGFLVLSPVTER
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07673 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNGERPAANGEQIANGFQQTVADSTPESGQLKTESVPSNPPPPSIDNTRNCANGDVESSQQPSDNKGSDVAHLHEQAP
2) VPINLPLNKAKAVPGNPNANNANLPNGPNSRLPAPMKAPPGKMQAPGGMIPNGANVKVQRPSGTGPGGRPMPPNHKANTNSAQKQEVIMLD
1
1076
78
1166










Molecular Recognition Features






MoRF SequenceStartStop




NANANA