<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07668

Description Threonine synthase
SequenceMAATASQKYLSSRGGSYGFSFEEVVLKGLASDGGLFIPEQIPSLPADWETKWRNYSFQELAFEILSLYISSSEVPSNDLKDIISRSYGTFRSPDITPLVTLDEQKRLYLLELFCGPTFAFKDVALQFLGNLFEYFLVRRNEGKAGKDRHHLVVIGATSGDTGSAAIYGLRGKKDASVFILHPKGKVSPIQEAQMTTVLDENVHNISIEGSFDDCQDMVKALFADPEINKTHKLAAVNSINWARILAQITYYFHSYFSLIRSPTYVKDKPIRFIVPSGNFGDILAGWFGKQMGLPADKLVIATNENDILDRFLKTGQYTKQAQPETQASPSAVKETWSPAMDILVSSNFERLLWFLAYKIYGQGDIDEKRKIAGNTVLGWLQDLSSKGGFGVDEKILQAAQQEFESERVSNEQTIDTIRSIYSTCFPQTPVSAGTRGETGGYILDPHSAIGVAASLRSISRCAETFHISLSTAHPAKFAEAVDAALRNEKGYSFDNVLPPEFVGLEKKERRVISMPAGATWKSQGMTNRTFRLLSFDIFGTLIDWETGIHEALEPLVQRLDDSNPLKTDRKKLGDLYGKHERAIQVDNPRLAYNLVVKEAYERLARETQSLPATEPLLDKESTAFGNSVGRWPPFPDTVAAMRRLKKKGYKLVPLSNVDRESFSNTLAGPMAGLRDGLALEEPFFDAIYTAQDVGSYKPNLRNFEYLISHVKSEFGIEAADILHVAQSLHHDHEPAKKMGLSSVWISRRDGSSSMGTDVREHLDAGWQFDDLAGLVDAVEASLPLQLFLPPKEERRTSTSATCNFTSHLPQDLDLLHAAACSKRTPKKTIEGFGSLRPGSILFSAAPPPPSDAARSSSSSSVPRPDPFHHRHIQARRSHARVHSSPQNYESSSSTTKSTSPAHTAAQSANLSSPPSSVAMQPHSVSQSTVTTSTSCPTPASSTSGLARDGSDGSGAIAASFADGKIPFETLGSDTKHFAHDHHNNEKSVDTQKPSSNDSNDHDPMDVDLKEGAGLSEEPSLESLQRDVGEAIGLCKSTYTTTLPVPKFDIISLYGLGPIAASVARTDPVTGEKINRLRKSYEGKIKGLGLAGRNKPVKQEPGAPGGLRNLMMWPDEEWYNQKVAGKEITIAEPDTAFYKQQLRAMKMEPGITPRNEYWEDVLGHEKSSKNAAEQLPKKLVSSSFKNTPQSNGTPAAQASSATVAPDPGRPKRAGRKRSYHDSSFVGYGEGFPDDDDLEGSLYSNDDDGGSVGKKKRKKMQEHATGGPPPFERGGSYGVGMFGIGAR
Length1285
PositionHead
OrganismTrichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Arthrodermataceae> Trichophyton.
Aromaticity0.08
Grand average of hydropathy-0.475
Instability index44.94
Isoelectric point6.37
Molecular weight140667.15
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
pyridoxal phosphate binding	GO:0030170	IEA:InterPro
threonine synthase activity	GO:0004795	IEA:UniProtKB-EC
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
threonine biosynthetic process	GO:0009088	IEA:UniProtKB-UniPathway









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07668
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.23|      63|      66|     202|     267|       1
---------------------------------------------------------------------------
  195-  262 (96.66/77.95)	TTVLDenVHNISIEGSFDdcqDMVKALFADPEINKTHKLAAVNSIN..WARILAQITYYFHSYFSLIRSP
  263-  329 (99.57/70.59)	TYVKDkpIRFIVPSGNFG...DILAGWFGKQMGLPADKLVIATNENdiLDRFLKTGQYTKQAQPETQASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.07|      65|     471|      18|      85|       2
---------------------------------------------------------------------------
   18-   85 (108.02/69.14)	GFSFEEVVLKGLAsdgGLFIPE.QIPSLPAD..WETK.WRNYSFQELAFEILSLYISSSEVPSNDLKDIISR
  490-  558 (103.05/58.88)	GYSFDNVLPPEFV...GLEKKErRVISMPAGatWKSQgMTNRTFRLLSFDIFGTLIDWETGIHEALEPLVQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     360.80|      95|     198|     748|     878|       4
---------------------------------------------------------------------------
  748-  878 (139.94/126.06)	RDGSSSMGTDVREHLDAGWQFDDLAGLVDAVEASL.PLQlflPPKEERRT.STSATC....NFTSHLP.QD.LDLLH......AAACSKRTPKKTIEGFGSLRpgsilfsaappppsdaarssssssvprpDPFHHRHiqarrSH
  889-  981 (122.57/63.17)	ESSSSTTKSTSPAHTAA..QSANLS....SPPSSV.AMQ...PHSVSQSTvTTSTSCptpaSSTSGLA.RDgSDGSG......AIAASFADGKIPFETLGS..............................DTKHFAH.....DH
  989- 1077 (98.29/41.41)	.DTQKPSSNDSNDHDPMDVDLKEGAGLSE..EPSLeSLQ.....RDVGEA.IGLCKS....TYTTTLPvPK.FDIISlyglgpIAASVARTDPVTGEKINRLR..........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     241.38|      75|     568|      97|     179|       5
---------------------------------------------------------------------------
   97-  179 (113.78/85.25)	PLVTLDEQkrLYLLELFCGPTFAFKDVAlQFLGNL..FEYFLVRRNEGKAGKDRHHLVVIGATSGDTGSAAIYGLrgkkdASVFI
  669-  745 (127.60/75.16)	PMAGLRDG..LALEEPFFDAIYTAQDVG.SYKPNLrnFEYLISHVKSEFGIEAADILHVAQSLHHDHEPAKKMGL.....SSVWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     175.76|      40|     289|     336|     375|       6
---------------------------------------------------------------------------
  336-  375 (68.05/54.32)	WSPAMDILVSSNFERLLWFLAYKIYGQGDIDEKRKIAGNT
  591-  627 (49.05/36.55)	...AYNLVVKEAYERLARETQSLPATEPLLDKESTAFGNS
  631-  665 (58.67/45.55)	WPPFPDTVAA...MRRLKKKGYKLVPLSNVD..RESFSNT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07668 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDDDLEGSLYSNDDDGGSVGKKKRKKMQEHATGGPPPFERGGSYGVG
2) PRNEYWEDVLGHEKSSKNAAEQLPKKLVSSSFKNTPQSNGTPAAQASSATVAPDPGRPKRAGRKRSYHDSSFVGYGEGF
3) RPGSILFSAAPPPPSDAARSSSSSSVPRPDPFHHRHIQARRSHARVHSSPQNYESSSSTTKSTSPAHTAAQSANLSSPPSSVAMQPHSVSQSTVTTSTSCPTPASSTSGLARDGSDGSGAIAASFADGKI
4) TLGSDTKHFAHDHHNNEKSVDTQKPSSNDSNDHDPMDVDLKEGAGLSEEPSLESL
1232
1152
836
969
1278
1230
965
1023










Molecular Recognition Features






MoRF SequenceStartStop




1) DLEGSL
2) VGKKKRKKMQEHATGGP
3) YGEGFP
1235
1250
1226
1240
1266
1231