<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07664

Description Uncharacterized protein
SequenceMTSRPGPGIHESLQSRGGGVPPRNQVRPRLSKPAGTLIQPDAIDPNLEDDQHHGAAEFTRPLPRGRPQLYFSTVSTNGIDLPIHPFPYQPTTNLPVPPRPGSVHLRDASQQRRILPGGTGVKDAPKLTPPEAISPPVHFPGGIAADVFPWTGNNAEDTLSESLVKAGISNKPQIMNETNTARPSLWSNLKNKSGLSTLSTLFAAVLEKRQQSGRLQTPNTFKPPPRLTLRDSTREQWLHDLANPTIGLRRLSRTIPHGLTGKVLLEQCLNKNIPLPRALWLAKCVGINELRAHKRKGQAGTVTWGRGWTSSVEQFLDGVISTIGLGDWKPRVTYSLQLATHLYKEHLLDDDHFLEWIVHGLETCPPERLFIWLLVVSVSHYWADITCCRRRGKRLAESLLNQLDKIYRLEDYTPYAAVLQYLENTLVKLLATRPACLLLPASWTKYEILLQTLAERRNHPQITHAIEKLEERNIRLLQTSKSITSTPQTISGRVYRVLDAVNYNSPVRIDDLSYECMEILSDAPKLVAIVTHWACSCYREGTHRVFLATRLFRRWSHLGADVYEGILSYLRGMGWVGTGDLNIIFKIVAELVRSKTFAVGRYLQWLIATGSLGSGENTTSQSSWPVRLITEIPLSGLPHQIRALRSTLLRGTVQSTELEQRALEHAKEIISNAIPAVFGRYNTAAKIPQITLETLSSTVKLELGIWLRQHVAQYAEVNQHVPTKDPSVEETAAVSLMAAHEFHIVRNYLESFGDLAILADVVGIVTSSLDSTVLASAADTINYHMRTFRALGAFDPLFGKIANRYAAIRTIRFPERELLLSLSNLTRVARTDGQLQQLLSYDLSRLDQRNSLAACSPASDNMGEIMLTGAYSDDEIERILSSGTSMDQQMMARVLRKIVSNLEEHVAKAHGQFESYSAWFHRLRSFDEPSFDVVVNEWLDASFSAHNVSTLQLALPTLVGSACLMLSTVLDRLQIHITKSKSCPSEMATQTALVGLRMLLPHEELIRFCSSQDAYRYRLAQNKLCHDNGDRMVHCISEVHELGSSNAFPKAQGQLLILMSSEPVLSLMKHCLLSASNCLSQLSHEAMRTYVTNLFNTLLDPFGSLHLATQSAEEQVLTIFGIANELSLPICQAIIEHIFSTDATLSGESTDALSMALLSAIKTAVEEGQSAGLELLATFDASLTDKIRQHAEREIINASTFFTNSSTIKSDEDQSDQISAAVVQKYLTVIDLTSSKHTDQVEQSGMLILLVERFKGISHAFGDSDDQSVNLRSVQTDPLSVSEVYAWLNALLRLAVTHCSAMMRNASYQHQVALMVAMKGLMTHPSLELLPSITEHVFDVSVLLSDHISDDVRNHVARLDNGKLSDDSRCLFILGAIAPVDGWLVLTKPVNPPLNQPPSQPQTPVTSQSQSSPYQSPQLPTNGPAAQQQRYFNQQHQQHQQHQQHQQHQQHQRQQQMQAQQAQQMRGYPPHPQHTVQPNKMLPAQLQRTPSNQSSSTPLQQLQHMQQMQGLAQQRATQPSPVYSQRPAPAVGQSAMSSAAPGKLQIRQDREMKQFPFVQPRWEILAESSGNPNANETAISLTLFGARKV
Length1589
PositionKinase
OrganismPyrenochaeta sp. DS3sAY3a
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Cucurbitariaceae> Pyrenochaeta> unclassified Pyrenochaeta.
Aromaticity0.06
Grand average of hydropathy-0.270
Instability index49.39
Isoelectric point7.52
Molecular weight176798.29
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07664
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     147.24|      23|      25|    1393|    1415|       1
---------------------------------------------------------------------------
 1393- 1415 (42.19/20.33)	PLNQ....P....PSQPQTPVTSQSQSS....PYQ
 1420- 1442 (41.16/19.65)	PTNG....P....AAQQQRYFNQQHQQH....QQH
 1443- 1469 (33.66/14.65)	QQHQ....Q....HQQHQRQQQMQAQQAqqmrGYP
 1470- 1500 (30.23/12.36)	PHPQhtvqPnkmlPAQLQRTPSNQSSST....PLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.37|      36|      75|     663|     699|       2
---------------------------------------------------------------------------
  663-  699 (55.04/51.56)	LEHAKE..............................IISNAIPAvFGRYNTAAKIPQITLETLSSTV
  708-  773 (42.34/32.99)	RQHVAQyaevnqhvptkdpsveetaavslmaahefhIVRNYLES.FGDLAILADVVGIVTSSLDSTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.29|      46|      75|     823|     876|       3
---------------------------------------------------------------------------
  823-  868 (78.41/46.20)	SNL.TRVARTDGQLQ.......QLLSYDLS..RLDQRNSLAACSPASDNMGEIMLT
  900-  932 (23.20/ 7.13)	SNLeEHVAKAHGQFEsysawfhRLRSFDEP..SFD.....................
 1050- 1089 (54.68/26.04)	........KAQGQLL.......ILMS.SEPvlSLMKHCLLSASNCLSQLSHEAMRT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.87|      14|      17|     253|     268|       4
---------------------------------------------------------------------------
  253-  268 (19.98/14.97)	RTIPhgLTGKVLLEQC
  271-  284 (26.89/13.05)	KNIP..LPRALWLAKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.74|      16|      75|     232|     248|       5
---------------------------------------------------------------------------
  232-  248 (26.45/28.44)	STREQWLhDLANPTIGL
  310-  325 (28.29/22.68)	SSVEQFL.DGVISTIGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.92|      14|      18|    1347|    1364|       6
---------------------------------------------------------------------------
 1349- 1363 (20.91/15.08)	SDDVR.....NHVARLDnGK
 1365- 1383 (20.02/ 6.98)	SDDSRclfilGAIAPVD.GW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     243.11|      74|      87|      16|     100|       7
---------------------------------------------------------------------------
   18-  100 (123.06/103.26)	GGVPPRNQVRPRLSKPAGT.......LIQPDAIDPNLeddqHH..GAAEFTRPLPRGRPQlyfSTVSTNGIDLPIHPFPyqPTTNLPVPPRP
  101-  183 (120.05/71.45)	GSVHLRDASQQRRILPGGTgvkdapkLTPPEAISPPV....HFpgGIAADVFPWTGNNAE...DTLSESLVKAGISNKP..QIMNETNTARP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.44|      26|     208|    1121|    1146|       9
---------------------------------------------------------------------------
 1121- 1146 (44.71/26.46)	GIANELSLPICQAIIEHIFSTDATLS
 1320- 1345 (44.73/26.48)	GLMTHPSLELLPSITEHVFDVSVLLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.78|      12|      20|     190|     201|      11
---------------------------------------------------------------------------
  190-  201 (19.62/12.27)	KNKSG.LSTLSTL
  209-  221 (18.16/10.70)	RQQSGrLQTPNTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.41|      36|      40|    1501|    1537|      13
---------------------------------------------------------------------------
 1501- 1537 (58.47/37.52)	QLQhMQQMQGLAQQRATQPS.PVYSQRPA.PAVGQSAMS
 1543- 1580 (51.93/28.26)	KLQ.IRQDREMKQFPFVQPRwEILAESSGnPNANETAIS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07664 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LPIHPFPYQPTTNLPVPPRPGSVHLRDASQQRRILPGGTGVKDAPKLTPPEAISPPVH
2) LSESLVKAGISNKPQIMNETNTARPSLWSNL
3) MTSRPGPGIHESLQSRGGGVPPRNQVRPRLSKPAGTLIQPDAIDPNLEDDQHHGAAEFTRPLPRGRPQLYF
4) TKPVNPPLNQPPSQPQTPVTSQSQSSPYQSPQLPTNGPAAQQQRYFNQQHQQHQQHQQHQQHQQHQRQQQMQAQQAQQMRGYPPHPQHTVQPNKMLPAQLQRTPSNQSSSTPLQQLQHMQQMQGLAQQRATQPSPVYSQRPAPAVGQSAMSSAAPGKLQIRQDREMK
81
159
1
1387
138
189
71
1553










Molecular Recognition Features






MoRF SequenceStartStop




NANANA