<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07658

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLKTCTTNAQAIGDFEAISYQAFSISRIPSQPSVPLRDWNPSDDIRAVEADLRMRLHLVVPDTSRPWLWLFQPTTVEKATQSPLDLPDVDGYTLQRELSGTFKALDLARPPMRNIHPNLASSSNIATPTSASHKGFPAGVTRPGQGNIQPTATDPPQPPDYSLLYELFTSSVTALVLLHLVRNRNVVALNYRTFVSKSLTLEHHDQPKPVASEGLHWLTSINVYWTSSGTLLVSTFTDQNTDIRCVDDVTSPDEQDQLVGRCVRVAPNGSLAKISSFEDPLEAILDDNSHRQRKRARITTLEQNIEKWKTSVKRWLDWKGYSIRNLDRTSSWVRIRTTQSPQSVAQSPAGVNFERDILWPRALCFFYVSESLETTLRKSHTISSDSPYDASKWFETPDSTGFRDPLDVAQEWFLGKPDRDKILEARRKAKKIEEDVARRKEEQPGLLASSPLNARSGVYGDLQAVGGVYPTPPDGVVPGTTVSYADTPSVSGALPNVILAPGGNNPAINLSGPQENTHLEQVPLTSPTFPLTSDNFNTSSGNDDLFEDMEEDGFGAAGVNDADFDFFDGPDDEDVVMLDTPAQPEGKVTVIKDSNDVEAIALSDPPMKEEISDPLAALENALAAPIRPAEEDTQKIEVQSEQSQIFSMPEISDTTTTKSMRSKSKARTQVPREPTPPLSPHMIVKVLQPSPPKKDPSQNSSSNTLAIHHDSAFDPVNFSRKMSISDARYQDGRFSAHREKDVVDTSRSNPTKVKSLRDIPLLTKLRYAIGVASANKIPEITALARAYSDDSDSSSESSDESEEEFDHEVVSGPVGIVGGIILPAKRKLPTEGNATPLSVTSFADSFAGDWQDFHGLQFDEALLTQFEPNTWDWSLVRFSSPTEKAPSAARFNMPALPSSLSDMPDTPTSQSEFSVDFSEERPLSGKDSIAITQIVTDQIVSATLDLLREDFLIEPISTPFTSLESRWLAVVTEVFPEAVNCDVPALAAIHDCYPDLSTQARGQQRPPPRKINESTIPGSQMYQISAPYLRVRRADTQWDLLPPALAFWEPLGLSPISAHKNVVAFCIYPHSESLRPCLENFLVNLQLAYDGCKLGSYARVETVREFEGGLVPYKVTSPPTRRDAIKALRETCIQLGKLLAIQHAKIREQHDAKIDAFVIYMVDPFGDASALWELCSAFWMLFQTYGQGPPGRPDQPQKPDLVLQVVPMKYVASFDVPVILDPSAYAKLAREVYDRCPPSAPSGDKTSLNIYSAPAFQLEETLPRSVPFKLISEPALDLLRENCYMHVAYAISQDGTWITAAWTDTCGKSQAVVSYHLGTRVFGEIAKEIWQTTIDILQSRRVHWRVCVAKAGVMEREEFETWVMLIQCPTQINLFITLLTVDTEPTIKLTPSMPSTSNASGQGSANTPGSTPQAGVSPDPAVGLTPAATPSADPSASDPAADPEARLIDVTDETWGVIFAHRLHNSNSTNQFSPAMISSLLVKRGETFATSNTINQTVPDPEHGPIVIAVNILWIGAVGSTRAATSPFPPSGPGDGVSPGGAAANPSAAYTGTNSAPPSPSPVQDGGPRSASSLMWTPTPQTRGTAENLLKEVLAHYRALGLLAKLRGMRGTRHGSVPWHVAAVKRGVLGLGRVMGGG
Length1640
PositionKinase
OrganismPyrenochaeta sp. DS3sAY3a
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Cucurbitariaceae> Pyrenochaeta> unclassified Pyrenochaeta.
Aromaticity0.07
Grand average of hydropathy-0.340
Instability index50.85
Isoelectric point5.13
Molecular weight179286.40
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07658
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     381.11|      88|      91|     468|     556|       1
---------------------------------------------------------------------------
  449-  530 (124.92/76.40)	..LASS..PLNARSG...VYGDLQA................vG...GV..YPTP...PDGVVP.GTTVSYADTPSVSGALPN....VIlAPGGNNPAINLSGP..QEN.....THLEQVPLTSPT
  531-  628 (97.55/54.59)	FPLTSD..NFNTSSGNDDLFEDMEE..DGF.............gaaGV..NDADfdfFDG..PdDEDVVMLDTP....AQPEgkvtVI.KDSNDVEAIALSDPpmKEEisdplAALENA.LAAPI
  629-  718 (93.19/51.74)	RPAEEDtqKIEVQSEQSQIF.SMPEisDTTttksmrskskarT...QVprEPTP...P..LSP.HMIVKVLQ.PS...............PPKKDPSQNSSSN..TLA.....IHHDSA..FDPV
 1535- 1582 (65.46/33.58)	.....................................................P...GDGVSP.G...GAAANPSAAYTGTN....S..APPSPSP.VQDGGP..RSA.....SSLMWTP..TP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     297.28|      82|     123|     818|     901|       2
---------------------------------------------------------------------------
  818-  901 (137.00/99.33)	IVGGIILPAKRKLPTEG.NATPLSvTSFAdSFAGDWQDFHGLQFDEAL......LTQFEPNTWDWSLVRFSSPTEKAPSAARFNMPALPSS
  936- 1021 (120.67/78.55)	IVTDQIVSATLDLLREDfLIEPIS.TPFT.SLESRWLAVVTEVFPEAVncdvpaLAAIHDCYPDLST...QARGQQRPPPRKINESTIPGS
 1446- 1481 (39.61/19.22)	.............................................EAR......LIDVTDETWG...VIFAHRLHNSNSTNQFS.PAMISS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.33|      65|    1005|     146|     226|       4
---------------------------------------------------------------------------
  146-  226 (93.23/94.23)	GQGniQPTATDPPQPPDysllyeLftssVTALVLLHLVRNRNV.VALNYRTFVskSLTLEHHDQPKPVASEGLHwlTSINVY
 1188- 1253 (117.10/71.85)	GQG..PPGRPDQPQKPD......L....VLQVVPMKYVASFDVpVILDPSAYA..KLAREVYDRCPPSAPSGDK..TSLNIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.51|      13|     274|    1344|    1356|       5
---------------------------------------------------------------------------
 1344- 1356 (25.96/15.13)	VHWRVCVAKAGVM
 1619- 1631 (24.55/13.92)	VPWHVAAVKRGVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.11|      37|    1028|     356|     402|       6
---------------------------------------------------------------------------
  362-  398 (67.20/50.52)	PRALCFFYVSESLETTLRK......SHTISSDSPYDASKWFET
 1265- 1307 (59.91/24.31)	PRSVPFKLISEPALDLLREncymhvAYAISQDGTWITAAWTDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.06|      18|    1028|      98|     115|       7
---------------------------------------------------------------------------
   98-  115 (31.83/19.20)	RELSGTFKALDLARPPMR
 1106- 1123 (33.23/20.42)	REFEGGLVPYKVTSPPTR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07658 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AATSPFPPSGPGDGVSPGGAAANPSAAYTGTNSAPPSPSPVQDGGPRSASSLMWTPTPQTRGTAEN
2) AGVNDADFDFFDGPDDEDVVMLDTPAQPEGKVTVIKDSNDVEAIALSDPPMKEEISDPLAALENALAAPIRPAEEDTQKIEVQSEQSQIFSMPEISDTTTTKSMRSKSKARTQVPREPTPPLSPHMIVKVLQPSPPKKDPSQNSSSNTLAIHHDSA
3) IKLTPSMPSTSNASGQGSANTPGSTPQAGVSPDPAVGLTPAATPSADPSASDPAADPEARL
4) PGGNNPAINLSGPQENTHLEQVPLTSPTFPLTSDNFNTSSGNDDLFEDMEEDGF
1525
559
1389
503
1590
714
1449
556










Molecular Recognition Features






MoRF SequenceStartStop




NANANA