<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07656

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDPSYNMDVDDLFGDSEHVTLQTMAATPPVKGLAKRIDELASSGCCQKIAWSKNGCVAHISPDGYNIHLNVFSRDTKTGKWDLGKDIQVDLPQGRDIFPFVHLSWSHLGNELVVMDEAGRATIFTCAMALDRLQFMRAELVHPESEVDGVVGMHWLGILPYEQKNQIAWSAARDGSKWKWNIKPHTFHDAHHPVDGKASLVYLKRHGELKLRFQQMDNSWHESSAQLGPMISTKEPFTHAAFASNNDNTLLLAAYDLKRRLHLYRVETTWNVPEKRTQNTVPFDKPSIQVSLITIEDNCYPIDLSSGDLSNGTEPRGAAAARLTHLNFLPMTPDQEDGSVPTIQAIFCRPPNIVSFDQLNPQESPNSVIVSWSITQTQQNQLHPSLDQVTSKKKGVSSVPSQTSLLMKRQPDFTLHAVVLAFFPIWYNMYLTLCYSDGTIEFRKRATMENIVPDDNTDTVTSLLQAGFAFSHADPSLHVAFSPNHCIAVCMQQDGPVKLRTMDYQHGTIATDDNDPRHSAALAALILQSSSAANQYYSSDDIFAIIGDISDKTKQDFTNLLFDGLQVNIDCIDEMSNHHLILLGRSPFFVKALSAMHLLGLEGTIKRSLTSKMAWIILNIKYVTQILTTIARMHGSLDKSSLRPEVVPQFIGICRWVMHFMAYALDELFTIGRSLQDIEPADLTRDVLEKKIHELNKPIVLLFLSAFPRAMMKLWTQPITWVKRSAETYTKTNPDPSNAAQTPSPEIRRLYTPLHTAVNEVPFDWRWFETLVSETHADVRNIYKKANFSDVQRNAIERELLLGKIPDVLFPVARKLVTDSLWNSAAPNGGLADKLDVGRLMFFDTTWLGFQESRRGGAWHDAHVVDVCQKMIIRGLGTQSHPVIASQGSRARSESIQSFGGGGGVGGAMNGGEEGRKKKAQLRQCTRCGAYMEDVVQGLPGYTAHHAGWLMGVAKHCVCGNSWMLAEEKKWR
Length972
PositionTail
OrganismPyrenochaeta sp. DS3sAY3a
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Cucurbitariaceae> Pyrenochaeta> unclassified Pyrenochaeta.
Aromaticity0.08
Grand average of hydropathy-0.270
Instability index46.73
Isoelectric point6.49
Molecular weight108769.77
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07656
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.29|      30|     117|     333|     369|       1
---------------------------------------------------------------------------
  333-  369 (48.67/55.56)	PDQEDGSVPT.IQAIFcrppnivSFDQLNPQ....ESPNSVI
  453-  487 (47.62/34.46)	PDDNTDTVTSlLQAGF.......AFSHADPSlhvaFSPNHCI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.13|      33|     117|     572|     608|       2
---------------------------------------------------------------------------
  572-  608 (45.80/42.18)	IDEMsNHHLILLGRSPfFVKALsaMHLLGLEGT.IKRS
  692-  725 (56.34/34.64)	IHEL.NKPIVLLFLSA.FPRAM..MKLWTQPITwVKRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.74|      55|     117|      47|     109|       3
---------------------------------------------------------------------------
   47-  109 (93.23/64.06)	QKIAWS..KNGCVAH..ISPDGY.NIHLNVfsrDTKTGKWDLGKDIQVDLPqgrdiFPFVHLSW....SHLG
  165-  228 (83.51/42.73)	NQIAWSaaRDGSKWKwnIKPHTFhDAHHPV...DGKASLVYLKRHGELKLR.....FQQMDNSWhessAQLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.42|      27|     120|     537|     566|       4
---------------------------------------------------------------------------
  537-  566 (41.90/33.21)	YSSDDIFAIIGDISDKTKQDFTNllfDGLQ
  663-  689 (45.52/27.88)	YALDELFTIGRSLQDIEPADLTR...DVLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.44|      40|     392|     372|     412|       9
---------------------------------------------------------------------------
  372-  412 (64.80/51.07)	WSITQTQQNQLHPSLDQVTsKKKGVSSVPS...QTSLLMKRQPD
  765-  807 (64.64/45.93)	WRWFETLVSETHADVRNIY.KKANFSDVQRnaiERELLLGKIPD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07656 with Med16 domain of Kingdom Fungi
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