<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07655

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDPSAKRQRLDSTGRFSPASPPFDVAAKASGQPIQKPTHPRTPTSPPYPSMSSQPNGGYAVSSSTASSDKPSQSSDATTRSFSQAAMSVFARHPIATPASTTGVASVANIDSDGDAMMEDGPEDEAVRSSDYRRSNHNRQSESLWTRDGRLKASEGICGDQLFKLSTQTYEPSRPHPSQNLFKLYDLERLAHTVARNDPVTGEKINKLRKSYEGHIKTLQIAGKPKATKMDRVFLNPLSIPEEDWRLMKVQGKEVTKALNPDQMTLGPNMSKLLDSAFAGIAPGPLPPSDTAKYRAYIGTDDTVKPKPQDGPPNRTTPFASSAPTPSNIGQHRGPNRPERAGSKRHYTDAAFQGYGEGYGDEYADSTGGEDNAQGNMAKRRKLQFGGVSHPVEVGGARR
Length400
PositionHead
OrganismPyrenochaeta sp. DS3sAY3a
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Cucurbitariaceae> Pyrenochaeta> unclassified Pyrenochaeta.
Aromaticity0.06
Grand average of hydropathy-0.894
Instability index57.52
Isoelectric point9.32
Molecular weight43242.40
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07655
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.12|      13|      23|      19|      34|       1
---------------------------------------------------------------------------
   19-   34 (21.51/14.78)	PASPPFdvaAKASGQP
   44-   56 (28.61/12.65)	PTSPPY...PSMSSQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.07|      19|      21|     158|     178|       2
---------------------------------------------------------------------------
  158-  178 (30.35/27.64)	ICgdQLFKLSTQTYEPSRPHP
  182-  200 (31.72/20.79)	LF..KLYDLERLAHTVARNDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.79|      13|      21|     310|     322|       3
---------------------------------------------------------------------------
  310-  322 (25.08/13.02)	QDGPPNRTTPFAS
  332-  344 (23.71/11.87)	QHRGPNRPERAGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07655 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSDPSAKRQRLDSTGRFSPASPPFDVAAKASGQPIQKPTHPRTPTSPPYPSMSSQPNGGYAVSSSTASSDKPSQSSDATTRSFSQAAMSVFARHPIATPASTTGVASVANIDSDGDAMMEDGPEDEAVRSSDYRRSNHNRQSESLWTRDGR
2) SDTAKYRAYIGTDDTVKPKPQDGPPNRTTPFASSAPTPSNIGQHRGPNRPERAGSKRHYTDAAFQGYGEGYGDEYADSTGGEDNAQGNMAKRRKLQFGGVSHPVEVGGARR
1
290
151
400










Molecular Recognition Features






MoRF SequenceStartStop




1) AKRQRLDSTGRFS
2) NMAKRRKLQFGGV
3) TAKYRAYIGTDD
6
377
292
18
389
303