<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07645

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMTSRPALGTHGSGAPSRNQARRPSKPANTLPTVDCIDPALEDERPATTHNGAGEARPPPRGRPQLFYSTVASNGFELPLHPFPYQPTVNLPVPPRPGSVHSRDASHQQRIQPGGTGVKDAPKLTAPEIVPAPVQFPGGKAADLFPWTGNNSEDTLSETLVKGGISNKPQIMNETNTARPSLWSNLKNKSGITTLSTLFVAVLEKRQQNGRLQTPNTFKPPPRLTLRDSTRESWLHDLANPTVSLRRLSRTIPHGLTGKVLLEQCLNKNIPLPRALWLAKCVGINELRAHKRKGQAGTVTWGRGWTSSVEQFVDSIISTIGQGDWKPRITYALQFATHLYREHLLDDDHFLDWMLHGLDTCPNERLFIWLLVASIPQYWTEITSCRHRGKRLAESLLSHLGKLYHVEDTLISSTALHFLENTLLKLLATRPACLLLPTSWPKHSSVLKTLASKRDHPQIKQAVERLNTRNQRLLKSSRNSASSSRSLAARVFQKLDSVDFTAPVRIEDLSYECMELISNAPRLIAVLLQWASSCYRTGSHRLYLAVRLLRKWSHLGADVYDGVISFFQSMSWTVTGDVHILLRIVAELVRSKHFSAGRYLQWLIATGSLGGDLDLSSPSSWAVRLITAFPISGLSDQVRNLRYTLLRSTEHTTELEEQALNVAKHNLSLAAPVLFGLNFTVPSQSEIKLEDLSSTIRLELGIWLRQRVAQHAEVNEHVPTKDPSVEETAAVSLISVHDYHVVRSYLERSEDLAILADVVGIATSTLDPVVLASVADTLHFHMKAFRAIGAFDPLFGRVAMRYAAVRTVRFPEREMLLSLQGLARKVQPEGQLMQLLSYDLSRLDQKNSIAACSPASDSMGEVMQHSATCSDDEIERILSSGTSMDRQMMVRVLRKIISNLDEHTSKGYLHLESHPSWFWRLRNFDESTFDVVLQEWLDSSLMACQMRTLRSAVPHLVAAGCLALPDFMDSLRACITAEKSGQLVEPCAVALDGLSMLLPSADLDAHCLPQDAYRYRTAQYALCFDMDTRIVCCIGEVADMVSSTPTMANRREISKVLYGDMVMSIMKQHIVSQPDCLSRLKAGKSSLVAQGCFKSILNTLLDPTGHLHLTDTTSEEQVVAVFKVASELSLPICQAMIESLFSGHGAFETDTADALSAALLNAVRTAVEEDQSQGLELLTSLDRTVTEKIRTHAEREILEASSFLTALPNTAVESSSATSVALVQKYLTVLDLTSNEHATNTDQPSILIALVDRLKGISQAFNSCAASNLVANGTQRPSVLELYTWLDALLRLAVAHGVAMLRSATHMQQAALIAALDNLLVHTTLELYPSITEHIFDVAIFLSDHLSNDARNHTLRSETARSADSSRSYFILGAAAPVDGWLVLTKPIHGPTNQQPASQPSTPGTIQHQASPYQSPHMTASNPSTPQQRYFNQQQQQRQQMQQAQQAQQMRGYSQQNQHSMQPNRQLPAQLQRTPSYQSSSSPLQQMQHMQQMQGLAQQRNAQTSPAQSQRMAPAASQTANAPVNKPQTVNQQRDMRQYPFTQPRWEILAESSGNPSLNETAINLSLFGARKV
Length1572
PositionKinase
OrganismStagonospora sp. SRC1lsM3a
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Massarinaceae> Stagonospora> unclassified Stagonospora.
Aromaticity0.06
Grand average of hydropathy-0.256
Instability index47.27
Isoelectric point8.22
Molecular weight174093.15
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07645
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     203.03|      36|      37|    1447|    1482|       1
---------------------------------------------------------------------------
 1385- 1422 (54.86/30.38)	KPIHGPTNQ.QPASQPSTPG.TIQHQA.SP..YQSphmtASNP
 1425- 1446 (38.71/19.00)	PQQRYFNQQQQQ.....RQ....QMQQ............AQQA
 1447- 1482 (69.82/40.93)	QQMRGYSQQNQHSMQPNRQL.PAQLQR.TP.SYQS....SSSP
 1490- 1522 (39.64/19.65)	QQMQGLAQ......QRNAQTsPAQSQRmAPaASQT....ANAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     483.89|     150|     160|     763|     921|       3
---------------------------------------------------------------------------
  763-  894 (201.01/139.32)	.........................................................STLDPVVLA..SVADT..LHFHM.KA.....FRAIGAFDPLFGRVAMR..YAAVRTVRFPEREMLLSLQGLArkVQPEGQLMQLLSYDLSRLDQKNSIAACSPASDSMGEVMQHSATCSDDEIERILSSGTSM.DRQMMVRVLRK
  895- 1058 (227.92/169.46)	IISNLDEhtskgylHLESHPSWFWRLR..........................nfdeSTFD.VVLQ..EWLDSslMACQM.RT.....LRSAVPHLVAAGCLALPdfMDSLRACITAEKSGQL.VEPCA..VALDGLSMLLPSADLDAHCLPQDAYRYRTAQYALCFDMDTRIVCCIGEVADMVSSTPTMaNRREISKVLYG
 1061- 1174 (54.97/30.00)	VMSIMKQ.......HIVSQPDCLSRLKagksslvaqgcfksilntlldptghlhltdTTSEEQVVAvfKVASE..LSLPIcQAmieslFSGHGAFETDTAD.ALS..AALLNAVRTAVEE..DQSQGL..........................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.81|      31|      37|     149|     179|       4
---------------------------------------------------------------------------
  149-  179 (52.22/35.84)	NNSEDTLSETLVKGGISNKPQ..IMNETNTARP
  187-  219 (46.59/31.11)	NKSGITTLSTLFVAVLEKRQQngRLQTPNTFKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.51|      25|      32|    1233|    1259|       5
---------------------------------------------------------------------------
 1233- 1253 (30.29/15.51)	............SN..EHATNTDQPSI..LIALVDRL
 1254- 1288 (30.31/19.45)	KGISqafnscaaSN..LVANGTQRPSVleLYTWLDAL
 1295- 1315 (18.91/ 7.07)	HGVA..........mlRSATHMQQAAL..IAAL....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.00|      37|     154|     361|     411|       6
---------------------------------------------------------------------------
  370-  411 (55.16/63.11)	LVASIPQyWTeiTSCRHRGKR...LAESLL...SHLGKlyHVEDTLIS
  522-  564 (57.84/28.62)	LIAVLLQ.WA..SSCYRTGSHrlyLAVRLLrkwSHLGA..DVYDGVIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.53|      25|     160|      58|      90|       7
---------------------------------------------------------------------------
   58-   90 (38.57/41.88)	PPRgrpqlfySTVASNGFELPLHPFPyQPTVNL
  220-  244 (45.96/26.32)	PPR.......LTLRDSTRESWLHDLA.NPTVSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.90|      23|      36|     426|     450|       8
---------------------------------------------------------------------------
  426-  450 (33.96/30.38)	LATRPACLLlPTSWPKHSSVlKTLA
  465-  487 (37.94/23.68)	LNTRNQRLL.KSSRNSASSS.RSLA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07645 with Med12 domain of Kingdom Fungi
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