<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07635

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDATYNMDVDDLFGDSEHVNLQAINTAPPLKGLARRIDELGASGCCQKVAWSKNGCVALISPDGFTVNLKVFSRDPDSGTWDLRKDIPLEVPQGREQFPFVHLSWSHLGNDLAVMDSAGRVMLFSCAMALDRMHHIRAELAHPEAEVDGVVGMHWLAIHPYEAKNHIAWSATREGSKWNWHIKSHMFNDAFHPVDGKTSLIYLKRHGELKLRFQQNDSSWQEVSAQLGPLLSTKEPFTHAAFASNSDNTLLLAAYDVARRLHLYRVEITWNVPSDKRNASAGPFEKPGLHASLLSIDGNCGPVTFSAGDLSSDTEPRIPAAAQLTHLDFMPVTPEEGDGSLPTIQAVFCRPPNIGLFDQMQVQENPHSVLVRWEVHHKQQNQLHPSLDQVTSKKKSIGSISPQSIFKLQRLPDFSLHSVVLTVFPLWYNMVLALHYSDGTIEFRKRTTLETIMPDGNTNVMTSLIQAGFAFSHAEPALHIAFSPSHCIAACMQQDGTTKLRSMEFQHGILGSDDTDERHSAALAAIVLQSSSAANQYFSSDDIFSLLGPLTEKRTNDFIDLLFDGLQVNIDCGIDDMSSQHFVLLGRSPFFVKTLSAMNLLGLQGTTNRTLTSKIAWIVLNIKYVTQILTTITRMHGAIEKTSLRPEVVPQFIGICRWIMHFMAYLLDELFTLGREVQDLPSQSLTREMLEQKIHAINKPAVLILLSAFPRAMMKLWAQPIAWVKRSAETYANPNQATPAPEIRKLYTPLHSAVNELPFEWRWFEMLVTDTHNQVRAAYKRANATDAQRNHYERELMLGRIPDILVPIAKRLITDTLWNEQANNGCLADKLDMGRLMFFDTTWLGFQESKRAAEWHDTHVVDVCQKMIIRGTGTQQHPSATIVQQSRGRSDSIQSTNGETAPGKKKGQLRRCTRCSAYMEDVMQGLPGYTQHHASWLMGVAKHCVCGNSWMLAPEKPRAK
Length960
PositionTail
OrganismStagonospora sp. SRC1lsM3a
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Massarinaceae> Stagonospora> unclassified Stagonospora.
Aromaticity0.08
Grand average of hydropathy-0.253
Instability index46.11
Isoelectric point6.60
Molecular weight107656.76
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07635
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.81|      42|      75|     106|     152|       1
---------------------------------------------------------------------------
  106-  152 (62.65/48.59)	SHLGNDlAVMDSAGRVMLfscaMALDRMHHIRAELAHPEA...EVDGVVG
  184-  228 (68.16/38.81)	SHMFND.AFHPVDGKTSL....IYLKRHGELKLRFQQNDSswqEVSAQLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     214.66|      66|     333|       7|      77|       2
---------------------------------------------------------------------------
    7-   77 (105.25/77.03)	MDVDDLFGDSEHVNLQAINTAPPLKGLARRIdELGASGCCQKVAW..................SKNGCVALISPDGFtvnLKvFSRDPD
  330-  413 (109.41/64.88)	MPVTPEEGDGSLPTIQAVFCRPPNIGLFDQM.QVQENPHSVLVRWevhhkqqnqlhpsldqvtSKKKSIGSISPQSI...FK.LQRLPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.41|      37|      38|     617|     653|       4
---------------------------------------------------------------------------
  617-  653 (63.56/49.14)	WIVLNIKYVTQILTTITRMHGAIEKTSLRPEVVPQFI
  658-  694 (64.85/50.30)	WIMHFMAYLLDELFTLGREVQDLPSQSLTREMLEQKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.17|      20|     317|     434|     460|       5
---------------------------------------------------------------------------
  434-  458 (30.51/32.39)	LHysdgtIEFRKRTTLETIM.PDGNT
  478-  498 (34.66/16.40)	LH.....IAFSPSHCIAACMqQDGTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.62|      21|      37|     541|     562|       6
---------------------------------------------------------------------------
  541-  562 (33.95/26.38)	DDI....FSLLG..PLTEKrTNDFIDLL
  575-  601 (28.67/16.74)	DDMssqhFVLLGrsPFFVK.TLSAMNLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.89|      14|     333|     416|     430|       7
---------------------------------------------------------------------------
  416-  430 (24.37/15.52)	LHSVVlTVFPL...WYNM
  750-  766 (23.53/10.74)	LHSAV.NELPFewrWFEM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.53|      38|     446|     243|     287|       8
---------------------------------------------------------------------------
  243-  287 (53.27/53.39)	ASNSDNTL.LLAAYDVArRLHLYRVEITWnvpsDKRnaSAGPFEKP
  696-  734 (65.26/41.55)	AINKPAVLiLLSAFPRA.MMKLWAQPIAW....VKR..SAETYANP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.67|      17|     198|     305|     321|      10
---------------------------------------------------------------------------
  305-  321 (31.58/18.48)	FSAGDLSS.DTEPRIPAA
  505-  522 (28.09/15.70)	FQHGILGSdDTDERHSAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.92|      16|     829|      90|     105|      11
---------------------------------------------------------------------------
   90-  105 (32.10/17.31)	EVPQGREQFPFVHLSW
  921-  936 (32.82/17.84)	DVMQGLPGYTQHHASW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07635 with Med16 domain of Kingdom Fungi
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