<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07634

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLKTCSTNAQAIGDYDAIAYQAFSVSRDTASPALLQRDWTSADDIRAVEAHLRHAHHLVTQDASRPWLWYFKPAAADMVGQDSVELPVVEGYNLHREQSGFIKAAEMARPPLRPGNPHPLSHPATSATNANAPKASQNAGVRHMQANQTAATDQPQSLDYFVIYELFVTSVTALVTFFMVRTCGLIALNYRTLILKAVESDEQRNRNNATTLHWLVNVHVQWFSSGTVLVSTSTEQSRTLRCLDSISDSDQKCLVGHCVRVAPNAMLARVSSFEDPLESTVTDAKDDVRRGAKKKRIASLEHNIGRWKSAVERWLSWRGYSLHGLDQPAAWVRIRLGHVVQVPIVSPGSSTLDRDILWPRALCFVSCFTHPGPLFTEAYGVPSPPSFDVDLKWFEGEGSHGFRDPIDVAHDWFVGKLERDKSLDARRKAKKAEEDAMRRKDEPTGLFPSSPFTTRSGAYGDLQAVGGVYPTPPDGVAPGAGFSSTDTASMSGVATNVILASGGNNPSINLSAPQDHPSHDEQQHPATSPAFPAMERFQTSGETDDLFEDAEGDGYAGDGVEDADFDFFDGPDGEDVDMADAPSMPQDDTQLPAQNGQRISTEVASVPSVKEEMSDPLSALEKALSIPLEPVKDQVQNTGAAQQPSKDVPPSQVPSDTTASQLATESPRDPPKSKEPTPPLSPGIIANALQPSPTSRSTVQKSTSTLADHAESAFHSLDFGRRMSLVDAKYQDGQFGRVKQDSEIDNGRTSSSAHPTRIKSLRDLPLLSNLRYAVGVATTSKAPKILSLARDVSDDSDSDTESVTSDASVAQAQTVADDRPPPFLGRLVIPTKRKIPTEGHGTPLSVTSFADSFGGDWQEYNGLQLEEASLTLFEPNTGDWAMANLPPPTERRSAGTRYAIPSLPRSLVQLPDTPTSQPDFEMDFPDEKPFSGKENIFITQIITDQIISATLDLLNENDDSVSTSIDKSSTESRWQAMLKDLFPKAAECSLSGLIAIHDVFPDLSSQAKGQQRPPPRKPNEGNAVPGNHMYQMNPPFIRVRRAETHWDLLPPSIAFWEPLGLAPVSPAKNVVAFCVYPDSDPLRPILDRFLLNLQLAYDTCKLGSHARVETVQEFEGGLVPVNLESHISSKGAFKALRDTCVQLGKLLAIQHAQIGEQQDTKVDAFVVYMVDPFGSPAALWELCSAFWALFQAYGQGPLGRPDAVQRPDVVLQIIPIKYLASFDNPVILEASTYVNLAREVYDRCPPSALSTDKTPLSIYKAPAFQLEESLPRNIQFKLMAEPPQDLLRENSYMHLAYAISLDGAWVTAAWTDSCGKSQAVVSYHLGTRVFGEVAKEIWQTTIELLQSRRVQWRVCIAKAGALDREELETWVLLITCPTQVNLFLTLLTVVEDSPYQFTPATSNTSNSSASQAVNTPGSTPQPSVSPDPAAGLTPAATPCADNAPDLTADPEARLVDVTDETWGIILAHRLHNSHSTNQFNPALISGLLVKRGETHSTSNSIHHHIPDPSPGPITIAVNIIWIGAVGSTRAATSPFPPASDGVSPGGAYPAAAAGSSSAGPSPSPHQERSTSSLMWTPTLQTRSTAENLLKEVLGQFRALGLLAKLRGMRGTKHGSLPWHVVAAKRGVEGLSRVTAGS
Length1639
PositionKinase
OrganismStagonospora sp. SRC1lsM3a
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Massarinaceae> Stagonospora> unclassified Stagonospora.
Aromaticity0.07
Grand average of hydropathy-0.340
Instability index47.37
Isoelectric point5.31
Molecular weight177901.23
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07634
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.52|      24|     125|    1402|    1440|       1
---------------------------------------------------------------------------
 1402- 1428 (36.01/34.13)	ATSNTsnSSASQAVnTPG..........STPQPSVSP
 1533- 1566 (40.50/10.03)	ATSPF..PPASDGV.SPGgaypaaaagsSSAGPSPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     148.02|      40|     124|     399|     447|       3
---------------------------------------------------------------------------
  402-  441 (67.17/39.52)	HGFRDPIDVAHDWFVGK...LERDKSLDARRKAKKAEEDAMRR
  734-  762 (36.00/15.19)	...........DGQFGR...VKQDSEIDNGRTSSSAHPTRIKS
  770-  809 (44.84/26.40)	SNLRYAVGVATTSKAPKilsLARDVSDDSDSDTESVTSDA...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     472.21|     130|     192|     982|    1121|       4
---------------------------------------------------------------------------
  876-  964 (124.89/53.57)	.....................................EPNTGDWA........MANLPPPTER.RSAGTRYAI..PSL....PRSLVqlPDTPTSQPDFEMDFPDEKPFSGKEN.IFI..T.QIITD..QIIS.ATLDLLNENDDSVS
  982- 1121 (209.22/117.84)	DLfpKAAECSLSGLIAIHdvfpdlSSQAkGQQRPPPRKPNEGNAV.P.GN..HMYQMNPPFIRVRRAETHWDLLPPSIAFWEPLGLA..PVSPAKNVVAFCVYPDSDPLRPILD.RFLLNL.QLAYDTCKLGShARVETVQEFEGGLV
 1137- 1246 (138.10/61.75)	AL..RDTCVQLGKLLAIQ......HAQI.GEQQDTKVDAFVVYMVdPfGSpaALWELCSAFWALFQAYGQGPLGRPD.AVQRPDVVL..QIIPIKYLASF.....DNPV..ILEaSTYVNLaREVYDRC...................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     232.30|      69|     170|     469|     540|       5
---------------------------------------------------------------------------
  494-  571 (96.50/44.21)	GVATNVILASGGNNPSINLSaPQDHPS..HDEQQHPAT.SPAFPAMERFQ...........tsgetddlfedaegDGYA.GDGVEDADFDFFD
  572-  631 (58.85/24.27)	..........GPDGEDVDMA...DAPSmpQDDTQLPAQ.NG.....QRIStevasvPSVKE..............EMSDPLSALEKALSIPLE
  632-  685 (76.96/31.47)	PVKDQVQNTGAAQQPSKDVP.PSQVPS..DTTASQLATeSPRDPPKSK........EPTPP................LSPG............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     317.98|      99|    1127|     119|     224|       6
---------------------------------------------------------------------------
  119-  224 (160.75/117.11)	PHPLSHPATSATNANAPKASQNAGV.RHMQANQTAatDQPQSLDYFVIYELFVTSVT...ALVTFFMVRTCG....LIALNYRTLILKAVESDEQRnrnnaTTLHWLVNVHVQW
 1248- 1354 (157.23/98.97)	PSALSTDKTPLSIYKAPAFQLEESLpRNIQFKLMA..EPPQDLLRENSYMHLAYAISldgAWVTAAWTDSCGksqaVVSYHLGTRVFGEVAKEIWQ.....TTIELLQSRRVQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.61|      32|    1007|     354|     389|       7
---------------------------------------------------------------------------
  354-  389 (55.01/44.38)	LDRDIL..WpraLCFVSCFTHPGpLFTEAYGV..PSPPSF
 1364- 1399 (49.61/27.59)	LDREELetW...VLLITCPTQVN.LFLTLLTVveDSPYQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.85|      13|     968|     460|     482|      10
---------------------------------------------------------------------------
  447-  459 (24.60/18.04)	GLFPSSPFTTRSG
  469-  481 (26.25/ 6.98)	GVYPTPPDGVAPG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07634 with Med13 domain of Kingdom Fungi
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