<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07627

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDHESGAATGPRDGDNKKRNYDGKLVNGESRDSPVTPAVNGGLSKASTGALAVPAPPISTPEHFTELPPEIAHIAQERYHPLSTLLLRISQETYNELSETLQSMAELPLVQQTNGILPNGVGAHRSGQPSQIERIKLYSSAAAERNPDITTALEVLSTGKAEWMPTMGYIPPEPISSEQALKLLRYMNTSLSIRLNVHETLPRRLRNWRIGSGRATFVIEKQLEFDVVSFVEDTSEQWWFVDVRLLFSPAPAITLGSHFFNRLQPQADVILKEKGLVGLFDFFCNFVLTHKIAVLRSQAIGLARSEWAGSLKVENVHRELVVSYWTDRPGKKNWIEIGVSKNKSSTGKTSWRGPPLPSLTVRWFRRGIEVKDVQFDFDWQNLSFERVLKRVIAKHTNDILEKIRENFHTQIQTKATLLDSEPANSRLKVTLGTSSNSTSLSVESVTGNFILQPATGLSARAEGAFNQGREPKQMAMVLTQLLAQSMQDLVQKYAQQLGWHAVNRQSLRLDAVKSAVKLDVLQYAMYSPRGWSPKWALVAVVDPTGSSWWIFETASNGSAIEYAEQIKMDRPDGSCLLIERKILASIERVAVQLLSTRVTVRQLEREKKSFSLRYEFGRSSQMVKSVAADMQKLMAASPQRGFKFAEDGSFQILLSTPFGEDILGELRARLHDVNRLRSFASTLQKRQMRLGSSSLQRVQFQYGPSPHVAAIDFSTEKGVAIEMSPKNPHFRIHKLLTEIANERVPSLPTLFSGDATGLDRFCTTLVLTRPLVTALAQLDANAANLNLQNPAVHAHSLFKYRLTYQNPVCSFDVRAQSKDDRVYWFIEDNMKKHAPDLRPSCERSPTHRRIDSLVAKLKELFCGKGERWFGTRNGIVADIDGVGEALQKLNECVLSCTMEGGYKAPPPLEVPVANPPAQQPQQPQANGPQQANQQRMQQQARQQQQAQQQAQQQAQRRQQQSQQQMQRGQMPNGRPQQQHSQGMQARQGGRPGQGQDVIEID
Length1001
PositionTail
OrganismStagonospora sp. SRC1lsM3a
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Massarinaceae> Stagonospora> unclassified Stagonospora.
Aromaticity0.07
Grand average of hydropathy-0.473
Instability index54.70
Isoelectric point9.40
Molecular weight112075.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07627
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      87.75|      14|      15|     956|     969|       1
---------------------------------------------------------------------------
  918-  933 (22.74/ 7.89)	QQPQQPQ.....anGPQQANQ
  942-  962 (20.12/ 6.19)	QQQQAQQqaqqqaqRRQQQSQ
  963-  980 (22.91/ 8.00)	QQMQRGQ...mpngRPQQQHS
  981-  995 (21.98/ 7.40)	QGMQARQ......gGRPGQGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.10|      15|      15|     320|     334|       2
---------------------------------------------------------------------------
  320-  334 (29.75/22.92)	LVVSYWTDRPGKKNW
  337-  351 (26.35/19.30)	IGVSKNKSSTGKTSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.52|      17|      17|     758|     774|       5
---------------------------------------------------------------------------
  757-  773 (29.99/21.54)	GL...DRFCTTLVLTRPLVT
  774-  793 (23.54/15.23)	ALaqlDANAANLNLQNPAVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.21|      13|      15|     576|     588|       7
---------------------------------------------------------------------------
  576-  588 (19.78/14.98)	LLIERKILASIER
  593-  605 (20.43/15.73)	LLSTRVTVRQLER
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07627 with Med14 domain of Kingdom Fungi
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