<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07624

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGQTDSVTVPLENGIKSFSQPLALDKAPFSPTAAAHCHQATSSLSNGHDMTSIPEMSDEDRTKLLPEIPPNTFPFGELLSRTVQTTYTDLLDLAETLPSASNDERKKQLLNFCFAKRKLFTKLLVLLRASSKSKDIMTCQRVHAFIDHQDGAFSRTADDLFAIHSQMRVAKIANYDIQTAVDVLTTGTYQRLPKSLKAQLVSEEPLTADEVSRTKERLNDLIRMRLTCEEVVPAALRHNMKIENGYVLFKVPGEFSVTLTMSPGNSEQPWTLVDLQILAKSTSTGYGGSLPSLQPTQLQAFKDASQRHLADDKSSYWLIVRLYEFIHKFCLTYQLHILSSQASYLCQNRWMDHLQVEKQELVLKLNMWHNPSASNAVSYREYYQLRISAEYIPTVYPDRSFEPMSDSDGLQKVVLESLSQMIVNSGKNNGLKISLIGILGSTVRDIDIPDMIKLNTESLDIEELLLSITDYQSRIIICAMRDELLTNASDSSAGSLVHSAFTSEHVQMSMGIEAETGNSTSPTIKSMLPAASLLVMYRPESWVRLSVNPRTGIVIASLADASGLGSLVGANSSTCSPISENAPAGSTLSKESGNGLKRITTSIDRNLKIVEQQINANVRNTKQAILYLRRATTITQIETMALYLGLEVADFAHIGTDSPLKHLQTDKVRLTHLRFPGKDDNVLVIAAGTPNDIHHDNALHSQVSDTVIYSEDAEFYVWIMSLKPSEHRTKKPEFQIIPLSPADVPGVLDSTDSLIDVDTSFLTAKLRLSKTSQHQSFSQAWPRIDLPVLSKIQTASSNLFAFAKLTEQLDLNGLTYQILVKNIPGYIPKGQTHVGDIHIARLNPKVVLSVRELFSLYGHAAFKSTHSSNSSTMDPGSNMHIPNSNIYVYLEPAKSLSFSAKSQSPTAKIDAISTEHHTHRIVAKMRLPDRLLSLEAHSLKISEYIEYDGTSQTITFQYHSVNEYIECFITEFLRVISMIYLTLQLKRYTKALENMNVKMDFFNLLMVNVQLFPNTVMQIKWLPQHDSQTNESGFSVWHGEYAASFQHNDGSPDELMVIADLFTAILNKTKEIFPLIQLLHRVAPLVSLLEHIRQRRVAFGQTGVVLKILSLTHFRIVFPYFSQLCGIEFVYERPGSFMMFDASMLDYAAELGLGSLAKVGLGIFCDDSIVDNSIDTEHTLRPLPEYIDMPAVSVPGMDQMRPPRIGLLYTLGTRVAQELADSATATTDPPRSSRQVADTPTHSKHGSIVVLPHGILCTFSMIDTVMVGIEGYIDVMCASDLIFSYLKTQPVTHSIHEEQHCRILFATESSKAALTCHSNGRWGFVIAATERTHDNKAAVANIPDSKAWLDRLNHDVNAIPIPKRNSLQWLKTVVHIAMLPDIPLRELMSVTRVSNSLNNTKPLALEWILQSPPDAPPHIPAPGEMSFIFDRDLERMRLLI
Length1441
PositionTail
OrganismBatrachochytrium dendrobatidis (strain JEL423)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Chytridiomycota> Chytridiomycota incertae sedis> Chytridiomycetes> Rhizophydiales> Rhizophydiales incertae sedis> Batrachochytrium.
Aromaticity0.07
Grand average of hydropathy-0.129
Instability index42.90
Isoelectric point6.15
Molecular weight160662.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07624
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.21|      17|      19|    1349|    1366|       1
---------------------------------------------------------------------------
 1349- 1366 (28.61/23.26)	WLDRLNHdVNAIP.IPKRN
 1370- 1387 (27.61/16.69)	WLKTVVH.IAMLPdIPLRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.41|      11|      22|    1304|    1314|       4
---------------------------------------------------------------------------
 1304- 1314 (18.31/17.30)	ILFATE...SSKAA
 1326- 1339 (13.10/ 9.37)	VIAATErthDNKAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.08|      18|      22|    1247|    1265|       7
---------------------------------------------------------------------------
 1247- 1265 (27.89/22.15)	GSIVVLPHGILcTFSMIDT
 1272- 1289 (33.19/20.25)	GYIDVMCASDL.IFSYLKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.11|      18|      22|     773|     790|       8
---------------------------------------------------------------------------
  773-  790 (33.16/22.82)	SQHQSFSQAWPRIDLPVL
  798-  815 (28.95/18.90)	SNLFAFAKLTEQLDLNGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.56|      16|      20|    1090|    1105|      11
---------------------------------------------------------------------------
 1090- 1105 (28.40/19.93)	LEHIRQRRVAFGQ.TGV
 1112- 1128 (27.15/18.71)	LTHFRIVFPYFSQlCGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.61|      11|      29|     307|     317|      13
---------------------------------------------------------------------------
  307-  317 (19.70/13.19)	QRHLADDKSSY
  335-  345 (18.91/12.32)	QLHILSSQASY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07624 with Med14 domain of Kingdom Fungi
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