<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07621

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPPASMLSTQFGSGVGASTSSGSGRGPIAAAGAGVGAGGSSAHASGSIHTTRPPPGDPQHRLNLNAQPRLPHAPAHTAHTLTNIVRLPWTSAAPDRPGSSLGAPVFPEASPSASHTLYPSGPSISTPRLGSGSSPGNFSAHAPAPSTIGFSWRRYEVKLVDESDASTSTIREGPGRAQASKATQLQAERRLVTLQNLLSRCASLEGKRPLSTRDAVPPFFPQQGSSDSSPDSEIQALHAGEYLRDRLLYAFENPSLEGANTAPTSAQAFEHKSPQASDLPHVASSSNSASRSGRKRKRDPAANSSQPASFESVRDETKHTQPSSSAAKTFAALWIFEAVPTSQLKKARDLKGKGKARATDDTLPNLDALGSAAGDDLILALRKEISEILVADFDVAASGALNPSSSLFPSLRMDNLASPALLQPSRRHLSAHGLLVRALHERFLIDFVTAHGWDGRPIPSVPDAMGQDGQGPEVDGGQSDREAEMAQPAAVPENAANVNIGGITGRPRSGTIQSISEEGEIPEVEMEEGEHTEDGEIEEGEASEPVADEVQQDESVFEKRSRIQLPPRRRGLSPPRTHPVRFGSLVLLLPCSAPGTGFHGSVISSAADSVLCVRFQTSVGPEALVLCVSPTYLWLRQLGRGVSCHELQDLDEPNSTRGLDDPSKASPEAKSGMRILLAPMGFTDRAQERQWMRSCMPGPEKVFPEQETDVEHEDHVSTGRSIELVGALSARLNALVSGTQSGSSSVTHYDIDAARGISGRGLSILGGRDGEGESRDGPGPDLSSGGPEPGWWIPDSLRTRLENEGVDVAFLGSEPRWAVVRQTAAEDVRGSDASALNEEGSADPHGSTTICVADQEQPATPRPGLGPHESQDDIKLEAGAIKDPLDLQDKFGKDAFLWPLALCFLHPSPDPSPDPATQLADIGNEETNHRVLPTRLLPFEDVRGSPIYLPPKTLTYANVADVLDQAAQIFKHQSEDHVATEVRTGLVEPSVEHRTVPADAAFSPTQVRAHSPKSIDPSHRTFPGLNGFASSDMAKLASSGGDESLPTEWGYGLPTRDFRARQQTLFMTTEKATNIQNDFMHAEQPTVSLPATSVEAVPVTFALAQVEEDIQNSVLGVSHAGAPFCWPISADTGPSQTATDHPSLPGFTPSSFSVSSPAFGLNGQAISKTPRTPHSPMEDVVDQSVSVHAGNGYPTLRQHLAAIEAHSSGLNMEISPIGPSSGQHLYVDDAFATGFEKSTTDELDPQFLHSKYDSGKFAIPDILASPAQAGPPVSKESAPTQTSLVPRTPTRNRFRFITRRSLVKGTLHGTPSKRKTAEDARWISTRPGSLSSALAHLRDGTRGDEEISEIGTLETYSDSGGSEDSMEEGDEQDEEELLLFQTRNTLKELISGTDRVLDILTAHNLHHAPRPSNPQTSTLPAQAKSESKQPSQQAPVDEESEQQEQWRRTVLECIALNPPLRAQALAEQSNSLTLPSVAAHETGAILERFSAALVGPEMDMSSLLLRALIHPSPYLDTTGLDLPSASGTSGGASTEVEGGVDVLEPPYIIAGCQGYATRMAPAALKFWDKLGLSAVGGPKHVAPFVLQLDASDYLLSSAVKWLERIDHIFQLYGLGSHVPNSHSILRLGDGSTIDIAEVLGSMAIDTAQQECWEDTMSSIFDTLKTHADNASHIIIYIVGTPGWPIRWQGLTRMREDLTYMARQRLGAQGWQLQVRGVPQMMIFESGLGPLGAGHRLAFDLKRFAFAIYDSLQRAVPHATGRTLASLGRRGHGQGHAHELDLVQYPAFTLAPLFQRHMMDISLRWPLSSRDVVDRGLLLHVGYELRAAHDCVVMTVVDQRGQLFFIDAWTTKQVLVEDLATIWLKAVQFARRADVAWRFVLCKTSSMPMEEILAWSSLERCGMLRGPGILDVTLGCVDTDSPLTLLPTADAPSGLASGPAAPNAVMLDASSFNYALYPSHRFFVPPPVFGSHYPTSQHHRQSSATQHQSRPHSSFFDNKTPDDSSNILALASSATVRIPRETDYSTASTGTFSTHVFSVPAHRAAPHVLWFHILQVYSKDSHHSQSAEGARFFGHGRRQSAHAHLSKSGGTAGPSTDFGGFDPFLSAQAALHGRMSTKVGSHFGPNKARHGSPLLSGTVHSTSGHADYAGSPSLSASATATAANAAAAASVRAALNMRLRDITQSMHELQLLSTERYSLAEPACFLPAHLGLLAVAAPGLASYVPMTAGRRDSESSDGQD
Length2239
PositionKinase
OrganismTilletia controversa (dwarf bunt fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Exobasidiomycetes> Tilletiales> Tilletiaceae> Tilletia.
Aromaticity0.06
Grand average of hydropathy-0.360
Instability index53.77
Isoelectric point5.65
Molecular weight239488.13
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07621
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.00|      17|      17|      12|      28|       1
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   12-   28 (32.41/14.75)	GSGVGASTSSGSGRGPI
   32-   48 (31.59/14.17)	GAGVGAGGSSAHASGSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.32|      17|      17|      52|      68|       3
---------------------------------------------------------------------------
   52-   68 (34.71/18.35)	RPP..PGDPQHRL.NLNAQP
   69-   88 (22.61/ 9.02)	RLPhaPAHTAHTLtNIVRLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.78|      31|     235|     906|     942|       4
---------------------------------------------------------------------------
  912-  942 (56.31/36.18)	SPDPATQLADIGNEETNHRVLPTRL...LPFEDV
 1030- 1058 (41.06/13.98)	SSDMA.KLASSGGDES....LPTEWgygLPTRDF
 1068- 1094 (44.41/16.06)	TTEKAT...NIQN.DFMHAEQPTVS...LPATSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     165.11|      28|      49|     448|     475|       5
---------------------------------------------------------------------------
  448-  475 (52.99/30.38)	VTAHGWDGRPIPS..VPDAMGQDGQGPEVD
  498-  525 (45.68/24.90)	VNIGGITGRPRSG..TIQSISEEGEIPEVE
  754-  776 (32.43/14.96)	..ARGISGRGLSI..L...GGRDGEGESRD
  782-  807 (34.00/16.14)	LSSGG....PEPGwwIPDSLRTRLENEGVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     168.02|      39|     114|    1115|    1157|       6
---------------------------------------------------------------------------
   98-  135 (60.01/27.33)	..GSSLGAPVFPEASPSASHTLYPSGPSIsTPRLGSGSSP
 1119- 1157 (77.58/43.60)	HAGAPFCWPISADTGPSQTATDHPSLPGF.TPSSFSVSSP
 1268- 1287 (30.42/ 6.37)	QAG.P...PVSKESAPTQT........SL.VPR.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     469.39|     155|     839|     526|     704|       7
---------------------------------------------------------------------------
  527-  702 (243.18/196.56)	EEGehTEDgeiEEGEASEPVADEVQQD...ESVFEKRSRIQLPPRRRGLSPPRTHPVRFGSLVLLLPcsapgtgfhgSVISSAADSVLCVRFQTS....VGPE....ALVLCVSPtylwLRQLG..RGVSCHELQ....DLDEPNSTRGL.DDPS..K......ASPEAKSGMRILLAP.................MGFTDRAQERQwmRSCMPGPEKV
  838-  899 (54.18/18.07)	EEG..SAD...PHGSTTICVADQEQPAtprPGLGPHESQDDIKLEAGAIKDPLDLQDKFGKDAFLWP........................................................................................................................................................
 1472- 1581 (82.45/42.02)	...............................................................LTLP..........SVAAHETGAIL.ERF...saalVGPEmdmsSLLL...............RAL.IHPSP....YLD....TTGL.DLPS..AsgtsggASTEVEGGVDVLEPPyiiagcqgyatrmapaaLKFWDKLG.....LSAVGGPKHV
 1879- 1967 (89.58/44.06)	......................................................................................VLC...KTS....SMPM....EEILAWSS....LERCGmlRGPGILDVTlgcvDTDSPLTLLPTaDAPSglA......SGPAAPNA..VMLDA.................SSFNYALYPSH..RFFVPPP..V
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.66|      14|      17|     180|     193|       8
---------------------------------------------------------------------------
  180-  193 (22.18/13.59)	SKATQLQAERRLVT
  199-  212 (24.48/15.92)	SRCASLEGKRPLST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.60|      15|      24|    1679|    1693|       9
---------------------------------------------------------------------------
 1679- 1693 (32.16/17.65)	GTPGWPIRWQGLTRM
 1706- 1720 (29.44/15.49)	GAQGWQLQVRGVPQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.01|      17|      23|    1194|    1215|      10
---------------------------------------------------------------------------
 1194- 1210 (29.49/23.68)	PTLRQHLAAIEAHSSGL
 1219- 1235 (31.52/12.94)	PSSGQHLYVDDAFATGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.01|      37|     839|    1309|    1357|      11
---------------------------------------------------------------------------
  704-  746 (48.07/15.79)	PEQETDVEHEDHVSTgRSielvGALSARLNALVSGTQsGSSSV
 1311- 1347 (64.94/38.26)	PSKRKTAEDARWIST.RP....GSLSSALAHLRDGTR.GDEEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.14|      23|     949|    1161|    1189|      12
---------------------------------------------------------------------------
 1001- 1023 (43.14/23.57)	AFSPTQVRAHSP..KSIDPSHRTFP
 1165- 1189 (36.00/37.23)	AISKTPRTPHSPmeDVVDQSVSVHA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.59|      55|    1897|     216|     276|      13
---------------------------------------------------------------------------
  216-  276 (80.54/60.03)	VPPFFPQQGSSDSSPDSEiQALHAGEYLRDrllYAfENPSLEGANTApTSAQAFEHKSPQA
 2118- 2172 (94.05/49.85)	VGSHFGPNKARHGSPLLS.GTVHSTSGHAD...YA.GSPSLSASATA.TAANAAAAASVRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.58|      29|     151|    1238|    1267|      14
---------------------------------------------------------------------------
  359-  383 (24.89/12.02)	.TDDTL.PNL.....DAlGSAAGDDlILALRK
  396-  420 (41.57/26.55)	AASGALNPS..SSLFPS.LRM...D.NLASPA
 1238- 1267 (49.12/38.27)	STTDELDPQFlHSKYDS.GKFAIPD.ILASPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.21|      11|      21|    1585|    1599|      15
---------------------------------------------------------------------------
 1585- 1599 (12.84/15.17)	VLQLdasdYLLSSAV
 1608- 1618 (21.36/11.32)	IFQL....YGLGSHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.15|      14|      17|    1400|    1413|      16
---------------------------------------------------------------------------
 1400- 1413 (25.82/12.77)	LTAHNLHHAPRPSN
 1419- 1432 (23.33/10.78)	LPAQAKSESKQPSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.57|      41|    1897|     138|     178|      17
---------------------------------------------------------------------------
  138-  178 (72.91/39.23)	FS..AHAPAPSTIGFSWRRYEVKLVDESDASTSTIREGPGRAQ
 2036- 2078 (71.66/38.43)	FSvpAHRAAPHVLWFHILQVYSKDSHHSQSAEGARFFGHGRRQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07621 with Med13 domain of Kingdom Fungi
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