<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07602

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPPASMLSSQYGPGGNINTSAGASSSSSAGIPGAGAPGSGVGSSSIHHQFNLNAQPRLPHAPAHTAHTLTNIVRLPWTCAASDRGAGSNVGASTSAISDASPSASQTLYTAGGPSIATPRLGSAFSPGNASSTQVSVAPAIGFSWRRYEFKLENESDPSAATPGSGGQRATQGPKSTNDRRADRQLVKLRNLLTRCASLEANRTLGGGTDAAPPFSDNDFHALHAGEYLRDRLLYAFEAPPPESANTANTSAQAAEHALNPPSHAAASSASSASKPGRKRKRESTANPAQPEARESASTDETATSQTSTPSKALAALWIFEAAPISQLRSSHSKVRDPKGKGKARATDDTPFTLDPLGSAPGDDLIFALRKEILQILAADFDMTASGILNPSASLFPSLRPDSLASPAMLQPSRRHHIAHGLLVRALHERLLIDFVRAHGWDGRPISGATSQDEQGQAEQADEDQPKNEPEITQSTGATQGTATVNVGGTAGRPRSATIQSISEEGEIPEVEEGEHPEDGEIEEGEASEPVADEVEQDEPVFEKRSRIQLPPRRRGLASPQTRPVRFGSLILLLPCGVGSVAPSSADVVLCIRFRASVGPEALVLTVSPTYLWLRQLGTGICQQIDTLDDSESIAETDDSGRANNQGEKGTRILLAPMGFADLAQERRWMRFCMPGPENVFSDEPADVGHKDMVSTGRSIELVGALSAQLNALVAVSRPGTFFSGLGEGGGPLGKASASSDGAEGEGETGNETSESEAGWWVPEPLRTRLENEGIDLATLGCEPRWAVVRTAPTDERSGSEVLAQDPKDEEPGDVTISTGEIPQQLATPRAGLDTKSEAEGDGQTAASEGPLDVQGKFGKNAFLWPLPLCFLHPLPDSTTPIDTERAKQTIVPDQLPFSDVRGAPIYPPYKSLTCVNVADVLDQSAHMTNVQAVFSATQAPSLSPIAFNTGSQAVPRPNGLVSAEKVGGASDDAAKDTQDDWGYGLPTRDFRARQNLAISAEQATNIHSDFMRVEQSDAQVPATSAGVVATTSVPMQPEEDIWNSVLGVSNAGGGFKPSGNATAPHAHQMVPNGGLMSGVHNGTVQRRDLDGFDAMDLVTEDDFSFFDNVNAFDFGGLDGTDTMGTGVIPLQGSAAPFLDAVNLVPEPAVTMESLLGPGMARAVPNASVMMMLSEGDGHPTQTGVPMSGPISADTGPSQTATEHPSLPGFTPSSFSVSSPAFGLNGQAISKTPRTPFSPMEDVVDQSVSVHAGNGYPTLRQHLAAIEVHSSGVDMDNNPVVPSSGQPLRMNDSFVTAFEKDADEHDPQFLHSKYDSGKFAIPEIVTSPAQAGAPVSKDGASAQMPLVPRTPTRHRFRFITRRGMKGTLHGTPSKRKVAEDANWISSRPGTLSLALAHLRDGTRGDEEISDIGTLETYSDSGASDDTLEESDGQDEEESLLSQTKDTLKRLIYGTDRVLDSLAAHALQQAPYSPPTHTSTLPVQSKADSKDALQQTPVDEESEQEEQWRRTVLECIALNPPLRAQALAEQSNSMTLPPVAAHETGAILERFSAALAGPQMDMSSLLLQALLHPSTTSDANGLDVPSAPSNSGGTLMESDGGVDVLESPYIIAGCQGYATRMAPAALKFWDKLGLSAVGGPKHVAPFILQLDASEYLLNSAVKWLERIDLIFQMHGLGSHVPNNHSVLRLGDGSAIDIAEVLGSMAIDTAQQECWEDTMGSIFDTLKTHANNASHIIIYIVGTPAWPIRWQGLTRMREDLTSMARQRLGTQGWQLQVRGVPQMMIFEHGVGPLGAGHRVSFDLKRFAFAIYDSLQRAVPHTTGKSLVAMGPRGQGHDQDLDLVQYPAFTLAPLFQRHMMDISLRWPLSSRDVVDRGLLLHVGYELRAAHDCVVMTVMDQRGQSFFTDAWKTKQVLVEDLAVIWLKTVQFARRADVAWRFVICKSSSMSFEEVLAWSSLERCGMFRGPGILDVTLGCVDTDSPLSLLPTADAPSGLASGPAAPNAVMLDGSSFNYALYPPQRLFVSPPVFVSHYPASHQLRPSSSTSTQSRPNPLIHNHDDILALASSATVRIPRQTDYSTASTGTFSTHVFSVPVHRVAPHVLWFHILQVYSKDSHHHHHSSSTDGGARSGPAARPSGHHAHLSKSGGGGTAGSTNADFGGFNPFLSAQAALHGRMSSKLGSHFGSDARLGSSPLSAGMVHSASANTDYPTVSSTGVGPVYASSPSLTASAAATAANAAADASVRAALRTRLRDITQSMHELQFLSMERYALAEPACFLPAHLGLLAVSAPGLASYVPMTAGRPDSECSDE
Length2309
PositionKinase
OrganismTilletia walkeri
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Exobasidiomycetes> Tilletiales> Tilletiaceae> Tilletia.
Aromaticity0.06
Grand average of hydropathy-0.312
Instability index48.40
Isoelectric point5.26
Molecular weight244649.64
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07602
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.08|      13|      18|    1145|    1159|       1
---------------------------------------------------------------------------
 1145- 1159 (20.37/13.83)	VPEPAVTMesLLGPG
 1164- 1176 (22.71/ 9.80)	VPNASVMM..MLSEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.30|      17|      18|       8|      25|       2
---------------------------------------------------------------------------
   16-   33 (26.76/11.73)	NINTSAGASSsSSAGIPG
  260-  277 (27.54/10.38)	NPPSHAAASSaSSASKPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.06|      15|      18|     504|     518|       3
---------------------------------------------------------------------------
  504-  518 (28.30/13.93)	EEGEI..PEVEEGEHPE
  523-  539 (21.75/ 9.17)	EEGEAsePVADEVEQDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     148.73|      37|      38|    1771|    1808|       4
---------------------------------------------------------------------------
 1740- 1772 (39.25/20.33)	....GTPAWPIRWQ.GLT......RMREDLtsmarQRL.GTQGWQ
 1773- 1810 (63.33/43.39)	LQvRGVPQMMIFEH.GVGPLGAGHRVSFDL.....KRF.AFAIYD
 1812- 1848 (46.15/25.88)	LQ.RAVPHTTGKSLvAMGPRGQGHDQDLDL.....VQYpAFTL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      58.52|      12|      18|    1576|    1587|       5
---------------------------------------------------------------------------
 1576- 1587 (20.84/ 9.80)	SDANGLDVPSAP
 1597- 1607 (17.93/ 7.22)	SD.GGVDVLESP
 1611- 1622 (19.75/ 8.84)	AGCQGYATRMAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.97|      17|      18|    1401|    1418|       6
---------------------------------------------------------------------------
 1401- 1418 (26.25/20.27)	GTRGDE.EISDiGTLETYS
 1421- 1438 (25.73/14.48)	GASDDTlEESD.GQDEEES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.84|      16|      46|     545|     560|       7
---------------------------------------------------------------------------
  545-  560 (28.94/17.78)	RSRIQLPPRRRGL.ASP
  568-  583 (26.16/15.16)	GSLILLLPCGVGS.VAP
  593-  609 (20.74/10.03)	RFRASVGPEALVLtVSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.18|      40|      45|      76|     119|       8
---------------------------------------------------------------------------
   80-  119 (66.06/45.08)	AASDRGAGSNVGASTS.AISDASPSASQTLYTAGGPSIATP
  123-  163 (60.12/29.06)	SAFSPGNASSTQVSVApAIGFSWRRYEFKLENESDPSAATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.82|      16|      46|     436|     452|       9
---------------------------------------------------------------------------
  436-  452 (27.98/21.29)	VRAHGWDGRPISgATSQ
  485-  500 (29.84/17.12)	VNVGGTAGRPRS.ATIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.13|      33|     150|    1027|    1078|      11
---------------------------------------------------------------------------
 1027- 1059 (62.04/55.11)	GVVATTSVPMQ.P.EEDIWNSVLGVSNAG.GGFKPS
 1178- 1213 (49.09/14.62)	GHPTQTGVPMSgPiSADTGPSQTATEHPSlPGFTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     155.15|      37|      40|     781|     820|      12
---------------------------------------------------------------------------
  453-  477 (29.13/ 9.99)	...........DEQGQAEQADEDqPKN.EP.EITQSTG
  784-  820 (65.72/38.67)	PRWAVVRTAPTDERSGSEVLAQD.PKDEEPGDVTISTG
  823-  859 (60.30/27.38)	PQQLATPRAGLDTKSEAEGDGQT.AASEGPLDVQGKFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.92|      17|      40|     164|     182|      13
---------------------------------------------------------------------------
  164-  182 (24.19/19.83)	GsGGQRATqGPKSTNDRRA
  206-  222 (34.73/18.49)	G.GGTDAA.PPFSDNDFHA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.12|      25|      40|     957|     981|      14
---------------------------------------------------------------------------
  957-  981 (41.79/27.57)	RPNGLVSAEKVGGASDDAAKDTQDD
  994- 1018 (42.34/28.05)	RQNLAISAEQATNIHSDFMRVEQSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.47|      33|      40|    1492|    1530|      15
---------------------------------------------------------------------------
 1492- 1530 (46.86/39.58)	LQQTPVdeeSEQEEQwrrTVLE..CIAL.NP.....PLRAQALAEQS
 1533- 1573 (41.60/20.43)	MTLPPV...AAHETG...AILErfSAALaGPqmdmsSLLLQALLHPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.04|      21|      46|     282|     302|      16
---------------------------------------------------------------------------
  282-  302 (33.78/16.39)	RESTANPAQPEARESA.STDET
  309-  328 (29.10/13.04)	TPSKALAAL.WIFEAA.PISQL
  329-  350 (28.15/12.36)	RSSHSKVRDPKGKGKArATDDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.97|      37|    1482|     721|     772|      18
---------------------------------------------------------------------------
  731-  772 (53.79/54.05)	GPLgKASASSDGAEGEGETGNETSESEagwwVPEPLRTRLEN
 2216- 2252 (60.19/24.95)	GPV.YASSPSLTASAAATAANAAADAS....VRAALRTRLRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.62|      16|      20|     919|     934|      19
---------------------------------------------------------------------------
  919-  934 (27.57/15.06)	ADVLDQSAHMTNVQAV
  940-  955 (28.05/15.46)	APSLSPIAFNTGSQAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.78|      17|      22|    1350|    1368|      20
---------------------------------------------------------------------------
 1350- 1368 (27.23/24.18)	TPTRHRF....RFITRRgmKGTL
 1371- 1391 (26.55/15.28)	TPSKRKVaedaNWISSR..PGTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.46|      25|      36|    1624|    1649|      28
---------------------------------------------------------------------------
 1624- 1649 (41.21/31.42)	ALKFWDKLGL..SAVGGPKHVaP...FILQL
 1659- 1688 (35.25/21.25)	AVKWLERIDLifQMHGLGSHV.PnnhSVLRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     285.28|      88|     132|    1992|    2088|      31
---------------------------------------------------------------------------
 1992- 2088 (142.06/70.78)	GLASGPAA.PNA..VMLDGSSFNYALYPPQRLFVSPPVFVSHYPASHQlRPSSSTSTQSRPNPLIHNHDDILALASSATVriprQTDYSTAStgtfSTHV
 2125- 2215 (143.22/56.54)	GARSGPAArPSGhhAHLSKSGGGGTAGSTNADFGGFNPFLSAQAALHG.RMSSKLGSHFGSDARLGSSPLSAGMVHSASA....NTDYPTVS....STGV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07602 with Med13 domain of Kingdom Fungi
Unable to open file!