<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07585

Description Uncharacterized protein
SequenceMTSRPGPGIHESLQNRGSALPPRSQVQRRPSKPAHTLLQPDCIDPALEDERPPSVHSAAHDAARPPPRGRPPLFYTTIPPIHPVELPLHSFPYQPTANLPQPPRPGSLHLRDAPHQRRILPGGTGVKDAPKPGGPEAVVPPVHFPGGKAADLFPWTGNNPEDNLSEALIKAGVSNKPQIMNESNTARPSLINNLKNKSGLSTLSTLFVAVLEKRQQTGRLQTPNTFKPPPRLTLRDSTREQWLHDLANPTTGLRRLSRTIPHGLTGKVLLEQCLNKNIPLPRALWLAKCVGINELRAHKRKGQAGTVTWGRGWTSSVEQFIDGVIGSIGQGDWKPRITYALQLATHLYKEHLLDDDHFLDWIVNGLDTCPSERLFIWLLVVSISHYWTAVTCCRRRGKSLAESLLNQLDKIYRLEDLRPYLAVLQYLENTVIRLLATRPACLLLPTAWARYGPLLQKLADRKNHAHVTQAVRRLELRNARLLQSPKKAPSASQTPAGRVYRILDSVDYSKPVRIEDLSCDCMEIVADAPRLISMLLQWACTCYRDGAHRIYLATRLLRRWNHLGADVYDGIVSYLRDMAWVATGDPNILFRIVAELVRSKTFATGRYLQWLIATGSTGHSTDLSSPHSWPLRLVTEIPLSGLTDQIRTLRNTLLRGTMHSAELEQRALSYAEHIISQTLPTLFGIYTDTAKPNDVELDKLSSTVKLELGIWLRQHVAQYAEVSTHIPTKDSSVEETAAVSLLSPWDFHIVRSYLERFGDLAILADIVGVATTSLDPSVLASAADTINYHAKAFRAIGAFDPLFGRIATRYAALRTVRLPDRELLLSLASLARTAHADGQLPQFLNYDLSQLNQRNSLVACSPASDNMGEVMQTGSSSDDDIERVLSSGTNMDQQMMGRVLRKIVSNLEEHLAKGSFHLNSHHAWFHRLRCFDEPTFDMVVNEWLILSLMAQRTDTLRVALPTLVGSGCVPLTAFLDTLRACIAKFKTNPSEGGFQSALKGMLITLPSDTLVQSCSPQDAYRYRLEQRKLCLETEGRFTQCIGEVIGLGSMIPSQKTQAQLSDFLRSKPMLHVLKHRLVSDPGCLSKLNKEGSSHYFKPSLDNLLDPRGHMKLPEKSPGQQVLAVFALASELSLPICQATIEQLFSSSAASLGDSGEALSASLLSAIKTAVEEDQPSGLELLASLDAALTDQIRQHAEREIINASAFLCMSPAIKAEEAEKVSPAVVQKYLTVIDLTSSKRSETTEQTALLQALIERFKGISQALEDSRLSVLEVYSWLNALLRLVVSHASAMLSDATHPHQTAMMSAMAALLIHPSLELYPTITEHVFDVTVFLSDYISDDVRFHVTRLEGARLASDARCVFILGVTAPVDGWLVLAKPVNTPLNQASSQPPTPTPLQNQQSPYQSPQVPANSSATPQQRYFQQQQQQRQQQMQAAQQAQQMRAQQQQQYHQHPQNKMLPAQLQRTPSGQASPSPLQQMSQMQQMQQMQQRAMQPSPVYSQRSTPAASQSQTSSQGQTGTQAPGKLQIRQDREIRHYPFVQPRWEILAESSGNPNGNETAINLSLFGARKV
Length1571
PositionKinase
OrganismAlternaria alternata (Alternaria rot fungus) (Torula alternata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Alternaria> Alternaria sect. Alternaria> Alternaria alternata complex.
Aromaticity0.06
Grand average of hydropathy-0.298
Instability index51.37
Isoelectric point8.89
Molecular weight174268.05
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07585
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     155.24|      20|      20|    1445|    1464|       1
---------------------------------------------------------------------------
 1398- 1414 (26.93/10.84)	QNQQSPYQSP.Q..VPANS..S
 1416- 1434 (32.06/14.31)	TPQQRYFQQQQQQR.QQQM..Q
 1445- 1464 (37.69/18.10)	QQQQQYHQHPQNKMLPAQL..Q
 1480- 1501 (29.31/12.45)	SQMQQMQQMQQRAMQPSPVysQ
 1508- 1527 (29.25/12.41)	SQSQTSSQGQTGTQAPGKL..Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     197.33|      49|      52|      48|      99|       2
---------------------------------------------------------------------------
    4-   37 (42.40/16.54)	...RPgPGIH..ESLQ............NRGSAlPPRSQ..............VQ....RRPSKPAHTL
   48-   99 (92.33/51.51)	EDERP.PSVH..SAAH............DAARP.PPRGRPPlfyTTIPPIH.PVELPLHSFPYQPTANL
  101-  158 (62.60/28.00)	QPPRP.GSLHlrDAPHqrrilpggtgvkDAPKP....GGPE...AVVPPVHfPGGKAADLFPW..TGN.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.69|      20|      20|    1179|    1198|       3
---------------------------------------------------------------------------
 1137- 1154 (17.80/ 7.69)	QATIEQLF.SSSAASLGDS..
 1174- 1193 (28.98/17.65)	QPSGLELL.ASLDAALTDQIR
 1194- 1214 (21.91/11.35)	QHAEREIInASAFLCMSPAIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.09|      30|      46|     958|     994|       4
---------------------------------------------------------------------------
  958-  994 (45.13/45.19)	VALP..TLVGSgCVPLTAF...LDTLRACIakfktnPSEGGF
 1003- 1037 (45.95/27.75)	ITLPsdTLVQS.CSPQDAYryrLEQRKLCL......ETEGRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.15|      17|      46|     663|     681|       5
---------------------------------------------------------------------------
  663-  681 (24.45/24.28)	LEQRALSYAEhiISQTLPT
  712-  728 (28.70/19.12)	LRQHVAQYAE..VSTHIPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.34|      16|      18|     256|     273|       6
---------------------------------------------------------------------------
  256-  273 (23.04/15.15)	LSRTIPhgLTGKVLLEQC
  274-  289 (30.30/13.66)	LNKNIP..LPRALWLAKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.41|      10|      18|    1290|    1299|       7
---------------------------------------------------------------------------
 1290- 1299 (18.85/10.95)	SAMLSDATHP
 1306- 1315 (17.56/ 9.65)	SAMAALLIHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.93|      10|      18|     302|     313|       8
---------------------------------------------------------------------------
  302-  313 (16.39/16.73)	GQAGTVtwGRG.W
  323-  333 (16.54/ 7.46)	GVIGSI..GQGdW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.83|      42|      46|     747|     790|       9
---------------------------------------------------------------------------
  747-  776 (32.07/25.44)	................FHIVRSYL.ERFGDLAilADIVGVATTSL.DP
  777-  821 (61.62/43.79)	SVLASAADTINYHAkaFRAIGAFD.PLFGRIA..TRYAALRTVRLpDR
  909-  936 (28.14/14.65)	EHLAKGSFHLNSHHawFHRLRCFDePTF....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.41|      15|      18|     405|     419|      10
---------------------------------------------------------------------------
  405-  419 (26.30/19.40)	LNQLDK.IYRLEDLRP
  424-  439 (21.11/13.84)	LQYLENtVIRLLATRP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07585 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELPLHSFPYQPTANLPQPPRPGSLHLRDAPHQRRILPGGTGVKDAPKPGGPEAVVPPVHFP
2) MTSRPGPGIHESLQNRGSALPPRSQVQRRPSKPAHTLLQPDCIDPALEDERPPSVHSAAHDAARPPPRGRPPLFYTTIP
3) NLSEALIKAGVSNKPQIMNESNTARPSLINNLK
4) NTPLNQASSQPPTPTPLQNQQSPYQSPQVPANSSATPQQRYFQQQQQQRQQQMQAAQQAQQMRAQQQQQYHQHPQNKMLPAQLQRTPSGQASPSPLQQMSQMQQMQQMQQRAMQPSPVYSQRSTPAASQSQTSSQGQTGTQAPGKLQIRQDREIR
5) YPFVQPRWEILAESSGNPNGNETAINLSLF
85
1
163
1381
1537
145
79
195
1535
1566










Molecular Recognition Features






MoRF SequenceStartStop




NANANA