<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07582

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNHTGSDLATASRDADGRKRNHDADMINGGLNGTRSDTPAGGPATNGGSSKDTNTNGASMALATTAGSTLGHYSDLPPEIAHIGPEQYNSLSTLLLRISQESYNELEEVLKNMAAIQLAPVTNGVLPNGLGAANMQGNADANRRKKLVLLSFAQEQRAKFIKLLVLTEWGKKASSDISKLIDLLAHASTQAAHMDAADYKLERIKVLSNNARENNPDIATALEVLSTGKASWMPSLDYIPPEPISAEQALKLLRYLNTSLSIRLNVHESLPRHLQNWRVHSGRATFVIDNELEFDVMSFVEDASEQWFLIDVRLLFNPAPTITVGSRFFMQLKLQADLVLKDKGLTGLFDFLNNFILTHKISVLRSQAVGLVRTGWAGSLKVEPVHRLLVVSYWTNKPGKKNWIEIGVSNNKPKNGKVSWRGPPIPSLTTRWFRQGKEVKDPKFHFDWKDLSMECVLKQVIACHASEILRSTKNSFKSGVIANARLSETEPGDCTLDATLGATSTSVTLSLEQVTGSYILRPASALSARAESAFNQGREPGQIANVMTQVLAGTLLSLIQKNAQQLGWQSVARQALHQQVVSAAVRLDVISSTLYCPRGWTPSWALAAVIDSSGESWWIFEIGSGGGSIEYAEQIRMDRPDGSSLPINRNTLASLERIAVQLLSFRVTARQLEKQKKNYSLKCELGPSLEAYRIARRWVLHVQTADLLAAQAGQDAWLESDIRITCEGMKVGGQNVWHMAAGRMIKTVAADMHKLMAASPQHAFKFSEDGNFRILLATPFGQDILGELRARLRDVNRLRTFATTLQKRKMLLKSSSLQRVQFQYGPSPYSATVNFGSEKELTIELSPSNPHHRILSQLTEIANDRSPSLPVIDPGDANGLDRFCTILVATRPLFKVLREVEQRSPGNYSNPAIHVHTIFKYRLTYDNPVCTFDVRLQPKDDNVYWFVEDNLRPKDPNVLPTPERAPGHRRLDNLQAKLKELFSRKGNGWFGTRNGMVAELDAIPRAIEELDKCVLGCRMADGYVAPPPLEKPAQQGLNQANGGQQGNQQQQQARMQQARQQQQQQQQQQQQQQQQQQRQGQSGKQHLNQQQHPRGQQPNGRPAQQQMPSGRQQTLQQQQQQGRGGPGGRPGQSKNDVITID
Length1141
PositionTail
OrganismAlternaria alternata (Alternaria rot fungus) (Torula alternata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Alternaria> Alternaria sect. Alternaria> Alternaria alternata complex.
Aromaticity0.06
Grand average of hydropathy-0.473
Instability index45.68
Isoelectric point9.39
Molecular weight126489.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07582
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.30|      16|      16|    1037|    1052|       1
---------------------------------------------------------------------------
 1037- 1052 (32.17/17.59)	LNQANGGQQGNQQQQQ
 1055- 1070 (30.37/16.12)	MQQARQQQQQQQQQQQ
 1077- 1092 (27.75/14.00)	QRQGQSGKQHLNQQQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.73|      13|      15|     391|     403|       2
---------------------------------------------------------------------------
  391-  403 (27.68/18.21)	VSYWTNKPGKKNW
  408-  420 (25.06/15.76)	VSNNKPKNGKVSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.01|      11|      17|     840|     850|       4
---------------------------------------------------------------------------
  840-  850 (19.82/11.85)	ELTIELSPSNP
  860-  870 (20.20/12.22)	EIANDRSPSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.91|      36|      39|     162|     199|       5
---------------------------------------------------------------------------
  162-  199 (53.40/46.67)	KLLVLTEWGKKASSDISKLIDLLahASTQAAHMDAADY
  203-  238 (60.52/45.19)	RIKVLSNNARENNPDIATALEVL..STGKASWMPSLDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.49|      25|      95|     554|     579|       6
---------------------------------------------------------------------------
  554-  579 (38.96/26.93)	TLLSLIQKNAQQLGWQSVARQaLHQQ
  651-  675 (39.52/22.89)	TLASLERIAVQLLSFRVTARQ.LEKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.97|      33|      60|     451|     483|       8
---------------------------------------------------------------------------
  451-  483 (56.57/44.74)	LSMECVLKQVIACHASEILRSTKNSF....KSGVIAN
  509-  545 (49.40/38.00)	LSLEQVTGSYILRPASALSARAESAFnqgrEPGQIAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.25|       9|      18|     589|     600|      10
---------------------------------------------------------------------------
  589-  600 (12.97/16.65)	VISSTlycPRGW
  609-  617 (17.27/ 8.93)	VIDSS...GESW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.45|      19|      19|     286|     304|      11
---------------------------------------------------------------------------
  286-  304 (31.31/20.82)	FVIDNELEFDVMSFVEDAS
  308-  326 (31.14/20.67)	FLIDVRLLFNPAPTITVGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07582 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DGYVAPPPLEKPAQQGLNQANGGQQGNQQQQQARMQQARQQQQQQQQQQQQQQQQQQRQGQSGKQHLNQQQHPRGQQPNGRPAQQQMPSGRQQTLQQQQQQGRGGPGGRPGQSKNDVITID
2) MNHTGSDLATASRDADGRKRNHDADMINGGLNGTRSDTPAGGPATNGGSSKDTNTNGASMALAT
1021
1
1141
64










Molecular Recognition Features






MoRF SequenceStartStop




1) KNDVITID
2) PAQQQMPSGRQQT
3) RMQQAR
1134
1102
1054
1141
1114
1059