<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07577

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDGASYNMDVDDLFGDSEHVNIQTINTTPPVKGLDGRLDELASIGCCQKIAWSKNGCVAYINPDGYSVNLKIFSRDPESGKWDLGRSVPLELPQGREVFPLTHLSWSHLGNDLAVTDDAGRVMVFSCAMALDRMHFTRAEVAQPESEIDAVVGMHWLAILPYAQKNLIAWSAAREGGKWKWNIKQHMFNNAHHPIDGKASFVYLKRHGELRLRFQQIDNHWQEVSAQLGPMISTKESFTHAAFASNNDNTLLLAAYDVKRRLHLYRVETVWNVPTDKRSQNAGPFEKPSIQVSLIALEDDCNPVDLANDDLSNGTASRGAAAAQLTHLNFLPITPEQDDGSIPTIQAIYCKPPNPLSYDLNAHETRYSIIVKWEVHQEQHSQLHSSLDQVTSKKKSVSSIPAQNTFLLKRQPDFSLHGVVLDFCPVWYNMLLAFAYSDGAIEFRKRSTMEVVMPDDNTDTVTSLLQAGFIFQHAEPSLHVALSPNHCMAVCMQLDGNPKLRSMEYSHGTLSSDDDDPRHSAALAALILQSSSAANQYYSSDDIFAIISSLSEKRKHDFINLLFEGLQVNIDCGVDDTSSNHFLLLGRGPFFVKTLSAMNLLGLQGTVERSLSSKMAWQIINIRFVTQTLTTIFRLHGDTSKNNLKPEGVPQMIGTSRWTMHFMAYIFDELFTIGRAISDLPAGTELTRSVLEDKIHELNKPALLLLLSAFPRAMMKLWAQPTQWVKRSAAAYVRPPQEGSPPGPPQTPEAKKLYSPLDQAVTEVPFEYRWFEVLISETQNHVRGIYKQRNLTDMQRNSIERELLLGKIPDILFPAAKRLVTDTLWNSNQQNGCLADKLDMGKLMFFDTTWLGFQDSKRARIWHEQHVVDVCQKMIIRGTGTWVHPVGSATGGGNRGRSDSTNSAAGANGDAAGGERKRRNLLKQCTRCGACMEDVVPGLPGYTAAHYQYLLGVSKHCICGNSWMLVETKGKAK
Length973
PositionTail
OrganismAlternaria alternata (Alternaria rot fungus) (Torula alternata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Alternaria> Alternaria sect. Alternaria> Alternaria alternata complex.
Aromaticity0.08
Grand average of hydropathy-0.308
Instability index41.27
Isoelectric point6.45
Molecular weight108606.23
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07577
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.93|      21|     119|      41|     113|       1
---------------------------------------------------------------------------
   41-   82 (32.05/101.43)	LASIGCCQK..IAWSKNgcvayinpdgysvnlkifsrdPESGKW
  157-  179 (36.89/ 7.28)	LAILPYAQKnlIAWSAA.....................REGGKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.62|      28|     117|     675|     702|       3
---------------------------------------------------------------------------
  675-  702 (43.43/24.24)	RAISDLPAGTELTRSVLEDKIHELNKPA
  789-  815 (44.38/24.92)	RNLTDMQRNS.IERELLLGKIPDILFPA
  818-  842 (37.81/20.24)	RLVTDTLWNSNQQNGCLADKL.DMGK..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.09|      25|     396|     101|     130|       6
---------------------------------------------------------------------------
  101-  130 (34.01/34.21)	LTHLSWSHlGNdLAVTDDAGRvmvFSCAMA
  500-  524 (46.07/26.44)	LRSMEYSH.GT.LSSDDDDPR...HSAALA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.38|      17|     191|     180|     196|       7
---------------------------------------------------------------------------
  180-  196 (34.06/25.11)	KWNIKQHMFNNAHHPID
  372-  388 (31.32/22.43)	KWEVHQEQHSQLHSSLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.69|      28|     143|     712|     743|      12
---------------------------------------------------------------------------
  712-  743 (44.36/37.84)	RAmmKLWAQP......TQWVKRSAAAYVRPPqeGSPPG
  858-  891 (47.33/27.27)	RA..RIWHEQhvvdvcQKMIIRGTGTWVHPV..GSATG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07577 with Med16 domain of Kingdom Fungi
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