<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07576

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDHSAKRQRLDSIGRFSPASPPFDVAAKASGQPTKTPIHPRTPTSPPYSSMNSQSHGGFAPTNSTASSDRSPQSSLPMSHSLSQSATSASNQHPFPTPASTAGFMSSANIDSDGDATMEESLDDDTTRLADHRLSNHNRQGESPYTEDGRLRAAQGISGSQLFKLNNDKLETARPHPSENFITLYRLTPLASSVARNDPVTGEKINKLRKSYEGQIKKMQIAGKPKATKMDGVFRNLLLMPEEIWQSQHVQNREPEKKALTPDGTALSSDFSRLLDDAFAGTAPGTLPSAEAAKYKAYLGTDDTAKPKPQDIPPQRATSFTSSAPTPTSHMNRGAVRPERSSSKRGYTDAAFQGYGEGFGDEYADSTGGEDTPGGNMANKRRKLQFERTSHSVEVGGARR
Length401
PositionHead
OrganismAlternaria alternata (Alternaria rot fungus) (Torula alternata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Alternaria> Alternaria sect. Alternaria> Alternaria alternata complex.
Aromaticity0.06
Grand average of hydropathy-0.905
Instability index55.91
Isoelectric point9.03
Molecular weight43270.09
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07576
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.38|      22|      23|     274|     296|       1
---------------------------------------------------------------------------
  275-  296 (37.05/18.38)	LLDDAFAGTAPGTLPSAEAAKY
  300-  321 (37.32/14.55)	LGTDDTAKPKPQDIPPQRATSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.99|      17|      25|      19|      35|       2
---------------------------------------------------------------------------
   19-   35 (32.38/14.78)	PASPPF.DVAAKASG..QPT
   44-   63 (25.62/10.39)	PTSPPYsSMNSQSHGgfAPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.19|      19|      19|     148|     166|       3
---------------------------------------------------------------------------
  132-  148 (29.19/16.87)	DHRL.SNHNRQGES...PY.TE
  149-  167 (29.32/16.98)	DGRLRAAQGISGSQ...LFKLN
  168-  188 (19.68/ 9.07)	NDKLETARPHPSENfitLYRL.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07576 with Med19 domain of Kingdom Fungi
Unable to open file!