<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07575

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMESMIKEWSVFLDKCLERRIQPDLFAAAVAQLHAKSPLPGRKLAALVLRPRVAGSNNIDPRSIVFLEQLLALKKVDASDVLTLTFLYSKDRLPVKTGDEKPTKEAQWDNPPELEEIVFHRLHKAFAAEERPINNTEGLRTLIVLTRWMQAMVTSHTSDSMIQAMAGIQQPQQHSINVREGLAMLVIGVVENSKILRILNNPKGKDIRKNFIQSFSSFIPFLSNNSGGSHQSLQLAERLELSQKRHDFYEKLPNVNGEENGNAGLEVAALQLDAVMELPQVNTRAGLYIFLNALLVARPLTDDFIIINHLHSRYKLEAQNMATDLITAAFDVLANAMYRSEPPQTMFYLKSFLINKVPLLLAQLTGSIFPMTVEMCITQALSHVDPHAFPSFSQGFDDIMGSNNNSLSDVRQDFLNACALHALIPTGTVERLLGEAPMQGPPSKRYERKELLNQCKSNFDKVSTFIDELESLDGNAGAIVAAVTDFIAHLCETQTTMYLKQLSSLLFKKPQAMDVMLQFTSPASILRPLCQFLDDWHYDSDQGEYQPVYDEFGAILVLVMAFIHRYDLTYHDIGIGHDTFIAKLLKRGHHSMLPDQLSEEQGKHLGNWLKGLYDADKEGLSNEVFASCRPQDFYLIVPTLFRQTVVACSTGVLSFESVKGGLEYLGETFLLPSLIEGLTWMASYALLQTHNDLDAMIRIFNEVILTTPSSGDAQAMHSTIIAMVSSRLEKCFRTLQRREPNRTTLEPFIQAIKVHAYYERSVYASLKEVDQWTNAPNSTLNSSIRHTIQQLSQWASTSSLQPNPPGYTHRQIYASLKMLGATRTLRAVVDEVKAQTDTGNGAAALDIGVSIICAPTVEDSPITVDWVGSSIPAPPQQRNHMNLREMLKQEFESAANLVATDPLTAETIVRLHRRVEAHFASLGEAGLQAPPINIPSVNIADMQSQTISDDLNRAIDDAAAATVVDDISNMDNKALQRSMDELTGPEGLDLSSIGMGNGDAGAGDMSTDLGNLPDLNLGDMGSMGMDMDMDMNMDMGGGGGDDDWGLDFDNM
Length1050
PositionTail
OrganismAlternaria alternata (Alternaria rot fungus) (Torula alternata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Alternaria> Alternaria sect. Alternaria> Alternaria alternata complex.
Aromaticity0.07
Grand average of hydropathy-0.165
Instability index40.47
Isoelectric point5.08
Molecular weight116305.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07575
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.18|      16|      25|     984|    1008|       1
---------------------------------------------------------------------------
  984- 1001 (20.95/13.18)	PEgLDLSSIG.MGNgDAGA
 1012- 1028 (28.24/20.54)	PD.LNLGDMGsMGM.DMDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.79|      37|      53|     725|     766|       2
---------------------------------------------------------------------------
  725-  766 (60.41/50.35)	SRLEKCFR.TLQR..REPNRTTLEPfiqaiKVHAYYERSVYASLK
  777-  816 (58.38/37.42)	STLNSSIRhTIQQlsQWASTSSLQP.....NPPGYTHRQIYASLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.75|      38|      53|     870|     908|       3
---------------------------------------------------------------------------
  870-  908 (61.51/45.34)	IPAPPQQRNHMNLREMLKQEFESAANLvATDPLTAETIV
  926-  963 (63.23/42.05)	LQAPPINIPSVNIADMQSQTISDDLNR.AIDDAAAATVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.48|      18|      25|     238|     255|       5
---------------------------------------------------------------------------
  238-  255 (32.10/24.10)	LELSQKRHDFYEKLPNVN
  264-  281 (29.39/21.37)	LEVAALQLDAVMELPQVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.66|      10|      19|     360|     369|       8
---------------------------------------------------------------------------
  360-  369 (17.19/10.07)	LAQLTGSIFP
  380-  389 (19.47/12.47)	LSHVDPHAFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.66|      39|     151|     314|     357|       9
---------------------------------------------------------------------------
  314-  357 (55.08/49.81)	KLEAQNMATDLITAAF.DVLANaMYRSeppQTMFYLK...SFLINKvP
  467-  509 (58.58/35.17)	ELESLDGNAGAIVAAVtDFIAH.LCET...QTTMYLKqlsSLLFKK.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.33|      23|      27|      98|     124|      11
---------------------------------------------------------------------------
   98-  124 (31.11/34.30)	DEKPTKEAqwDNPPELeeIVFHRLHKA
  128-  150 (40.22/26.45)	EERPINNT..EGLRTL..IVLTRWMQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.48|      23|      27|     531|     555|      14
---------------------------------------------------------------------------
  531-  555 (38.02/30.00)	FLDdwHYDSDQGEYQPVYDEFGAIL
  561-  583 (42.46/25.35)	FIH..RYDLTYHDIGIGHDTFIAKL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07575 with Med5 domain of Kingdom Fungi
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