<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07570

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLKTCNTNAQAIGDFEAIAYQAFSITRTTTPTSSRTRDWNTSEDIRAVEAQLRQDLQLVAQDASRPWLWLFKPTTVDKLEPNDAEPPELDGYRLHSEQTGCTKAIDLVRPPMRPGNPNTTATSTNSPSATQPQRGLHAGSARSSHGSSQPQASDSPSPPDCFTIYELFTSSVIALISFNVVKDCNVTALNYRTFVSKACKRADDDPYETEAPAPVHRLTSVNVHWASSGTLLVSTYTDYKTDIRCVGDISTQAEEKWLTGKCIRVAPNGLLATISSFDDPLDSIIEEIGLRHRKRTRLATLEQSIESWKSSVKRWLGWKGYALSDLEKKSSWVRIRTTLTNSPTASSPAFASPDRDVLWPRALCFFHSSEEHDMTSADSTVGGHSMLRWYETPESMGFKDPLDAAQEWFLGKLDRDKILEARRKARKAEEDSARRKDEQQNLFPSSPLNARGGAYGDLHAVSGVYPTPPDGVAPGTAVSHSDTPSVSGTVSNVILAPGGSNPAINLSAPQADTKMDEQQMPLTSPVVPSAPDNFNASSGNDDLFGDMDEDGYGGDRINDDDFDFFDGPDDNDVDMLDAPALPETNVVPIDTSHEQESQAAAEHPPEEDSSDPFAALESALATASEPAMDVEKEDKGKQPMTTEVPLVESPDLSDEKPVAPIAKAKVSFSKEPTPPLSPSAISKALQPSPPKKLASHTRPNQPVDTKNDAHFSPVVFSRKMSMSDAKYQDGRFSAHRPVDSVNQNSSSPSPGPRPVVMQTKSLRDIPLLSKLRITVGAASTNQIPEIASIARAASEDSDSSDTSDESDEDSGEEEEAGTTPAAIIGGLTMPAKRKLQSDGNATPLSVTSFADSMGGDWHDLHGLQLDELNLTSFEPSLWDWSLVHFPSPVERRTAGARYSLPSLHASPAQMPDTPTSQPEMSYEVSEEKPLSAKDSISITQIVTDQIVKTTLDLLGEDLPSEKEPVNEAIAETRWHTVIKEIFPAAAECDLPTLAGVHEVFQDYATLAKAQQRPAARKNDGPAVTGSHLYQINAPFLRVRRAETHWDLLPPAVAFWEPLGLSPISSPKNVVTFCIYPHSDALRPCLENFLLNLQLAYDSCKLGTHSRVETVVEFEGGLVPVRANSTVTPAELFKLLKETCVQLGKLLAIQHAKIREQQDSKIDAFVIYMVDPFGGPSALWELCSAFWALFQAYGQGSPGRPDQPQKPDLVLQVVPMKYIASFDTPVILDPSTYFSLAREVYDRCPPSAPSGDKTSLSIYAAPAFHLEETLPRNIPFKLISEPAQDLLRENTYMHLGYAISLDGTWVTAAWTDSCGKSQAVVSYHLGTRMFREVAKEIWQTTIEILQSRRVNWRVCIAKAGVLEREELETWVFLISCPTQINVFVTLLTAIDADPPYKFTPTMTGPSTAIGGSTNTPESTPQAGVSPSDLGPGLTPAATPSADPSATDPSADPEARLIDVTDETWGVILAHRLHNTQSTTQFSPALISGLLVKRGETQQTRNSISHPIPDPEPGPIVVAVNFLWIGAVGSTRAASSPFPPSSSGSTPSAASASSDLPSPGASTLPNPYASNPGTPQSPGPAQDAGQRSTTSLMWTPTPQTRTTAEGLLKEVLGQFRALGLLAKLRGMRGTRNGTLPWHVVAAKRGVEGLSRIGGAV
Length1656
PositionKinase
OrganismAlternaria alternata (Alternaria rot fungus) (Torula alternata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Alternaria> Alternaria sect. Alternaria> Alternaria alternata complex.
Aromaticity0.07
Grand average of hydropathy-0.404
Instability index52.99
Isoelectric point5.00
Molecular weight179447.52
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07570
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     446.78|     123|     125|    1329|    1452|       1
---------------------------------------------------------------------------
   85-  134 (32.75/ 8.63)	..................................................................DAEPPeldgYRLHSEQTGCTKAI..DLVRPP..............M.RPG.N....PntTATSTNSPSATQP...
  467-  513 (33.06/ 8.79)	...........................................................................YPTPPDGVAPGTAVSHS.DTP.....SVSGTVSNVIL.APGGS...nP..AINLSA.PQA......
 1329- 1452 (212.41/106.30)	RMFrEVAKEIWQTTI.EILQSRRVNWRVCIA.KAGVL.EREELETWVFLISCPTQINVFVTLLTAIDADPP....YKFTPTMTGPSTAIGGSTNTPE...STPQAGVSPSDL.GPGLT....P..AATPSADPSATDPSAD
 1456- 1583 (168.56/80.03)	RLI.DVTDETWGVILaHRLHNTQSTTQFSPAlISGLLvKRGETQQTRNSISHPIPDPEPGPIVVAVN..........FLWIGAVGSTRAASSPFPPSssgSTPSAASASSDLpSPGAStlpnP..YASNPGTPQSPGPAQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.97|      32|      32|     684|     715|       2
---------------------------------------------------------------------------
  684-  715 (57.57/29.19)	SKALQPSPPKKLASHTRPNQPVDTKNDAHFSP
  719-  750 (56.40/28.46)	SRKMSMSDAKYQDGRFSAHRPVDSVNQNSSSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.57|      36|     617|     552|     615|       3
---------------------------------------------------------------------------
  565-  610 (56.61/41.47)	DFFDGPDdndvdmldapALPE..TNVVPIDTSHEQESQAAAEHPPEED
 1172- 1209 (65.96/23.77)	DPFGGPS..........ALWElcSAFWALFQAYGQGSPGRPDQPQKPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.91|      18|      27|     985|    1010|       5
---------------------------------------------------------------------------
  985- 1003 (28.74/27.01)	PAAAECDLPTLAGVHeVFQ
 1015- 1032 (32.17/11.22)	PAARKNDGPAVTGSH.LYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.92|      29|     616|     436|     464|       6
---------------------------------------------------------------------------
  436-  464 (52.37/29.99)	RRK....DEQQNLFPSSPLNAR..GGAYG..DLHAVS
  834-  866 (44.18/24.03)	KRKlqsdGNATPLSVTSFADSM..GGDWH..DLHGLQ
  881-  907 (22.37/ 8.15)	.......DWSLVHFP.SPVERRtaGARYSlpSLHA..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.66|      18|     118|     516|     534|       7
---------------------------------------------------------------------------
  516-  534 (31.06/24.32)	KMDEQQMPLTS..PVVPSaPD
  634-  653 (29.60/17.62)	KEDKGKQPMTTevPLVES.PD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.78|      26|      27|    1601|    1626|       8
---------------------------------------------------------------------------
 1601- 1626 (41.63/29.96)	RTTAEGLLK.EVLGQFRALGLLAKLRG
 1628- 1654 (40.15/28.60)	RGTRNGTLPwHVVAAKRGVEGLSRIGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.98|      17|      32|    1046|    1062|      11
---------------------------------------------------------------------------
 1046- 1062 (34.96/22.41)	HWDLLPPAV.AFWEPLGL
 1079- 1096 (27.02/15.41)	HSDALRPCLeNFLLNLQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.66|      30|     549|     349|     381|      12
---------------------------------------------------------------------------
  349-  381 (47.00/33.08)	SPAfASPDRDVLWPRAlcFFHSSEEHDMTSADS
  908-  937 (54.66/27.59)	SPA.QMPDTPTSQPEM..SYEVSEEKPLSAKDS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07570 with Med13 domain of Kingdom Fungi
Unable to open file!