Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MASNTNQAPPGEPAKADIALLESLRTRLMSLVWILEQMKKELMANPTAPPDWPTIQRSISAVSNTITSIQSFINKDPETHSTFRALHSFPIPPFPAANESLGTIIEAILSKEPGAKEKDWILDKIIKAAEFAHVPSDWDIQAKPPVDEQDEDMDEGGEGSLKLRRQKANLDEDQLADLWRDVYDIVNEVAKVSNQNQEEDDSSASGDEEDEEMEDVLETGTPVQGVGGEKEKKVKEEQPMMSLDTIHRFMSTGSTFR |
Length | 257 |
Position | Head |
Organism | Paraphaeosphaeria sporulosa |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Didymosphaeriaceae> Paraphaeosphaeria. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.653 |
Instability index | 51.39 |
Isoelectric point | 4.46 |
Molecular weight | 28601.56 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP07562 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.67| 13| 16| 65| 77| 1 --------------------------------------------------------------------------- 65- 77 (23.21/15.20) TITSIQSF.INKDP 82- 95 (21.46/13.59) TFRALHSFpIPPFP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 70.20| 21| 84| 33| 56| 2 --------------------------------------------------------------------------- 33- 56 (34.97/27.52) WILEQM.KKELMANptAPPDWPtIQ 120- 141 (35.23/17.62) WILDKIiKAAEFAH..VPSDWD.IQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) LDTIHRFMS 2) SLKLRRQ | 243 160 | 251 166 |
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