<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07561

Description Uncharacterized protein
SequenceMNSRPAQGAQDPVQHRGNAPATSARRAAGQHGQEAAVDHDRAGEPPPKARPKGKPGPLDGIQTTATEPMRVPPKGKPQLFFSVAAHSGLESSEPSPTTAALPVPPRPSLSMPAEALNQRRIFPGGSGVKADPTVTKVVNQETPASAAVLPGGKAADFFPWTGSHPEDVLSEALVKGGISNKSQIMNETNTARPSLWANLKNKSGTSTLSTLFVAVLEKRQSCSRLVAPNTFKPPPRLTLRDSTRETWLHDLANPTVGLRRLSRTIPHGITGKVLLDQCLNKNIPIPRALWLAKCVGINEMRAHKRKGQAGTITWVRGWTSSVEQFLDGVISTIGQQDWKIRITYALQLAAHLFKEHLMEEDHFMDWILKSLDSCSSERLFLWLLITCIPDFWTSLISFRRRGKRLAESLLNHAGKIYSTSGESRETSVLGLLESIIARVAVTKSACLLLPDDWEKCKVVLYVFAQRRAHAKISQVIPGLDQRNRDIMPSRSLGSSASQRSYRVLYQFLDGVDYETNISVDELAYECMELFPDHDRLISAVLQWSSSLYRQGLHRVYLATRLLRKWNHLGIDVSEGILRYLPRLALDPSKDAELVFRVVSELVRSRTFSLGRFLQWLIATGSMDPGQDHHAAIAWQLRLLTEVPLSGLSEQVLNLRSTMLRGSVYSVDTEDDLILNTQDSILQQLTDFTLTDPNGLRRMTLNIGRLSRTMCLEVAIWLRRQVAATIETSDRAPTKESSIFMAGSVCTISSSCFEIVRHYLEQFKDLSILADVVGISATSFDAHILGASADTLCYHFKAFKAIGAFNPLSEKIVMRYTQIRAIRLPERSLLLSISALSHLTTVDSQLTQLLDYDLSRYDHRNSPAVCSPVSDTMIENVTGSDPEDEIERILSSGNSMDQHTMNRVFKKVVAYLDQRSSQGSYPSEGLLSWFCRLQSLEENTFHAIVVSWLQSVLTDQEPRILAVALPPLVVSGCLSLSRFAETTRDYMRRLQPNHFVESFRVAINGLDIILPRHELSDLLPHSYLYQFRTKQVAFCQKQDSGLLELIKGALDLISVHPDLCSGDSLPHVLSDGRLLGVLRHSAAVDFQNVSFLLDCSARITSGVSQTGIKSLLDRIMDPLNALDLSRLSHEEQATAIFRYADQLSLSFCQLKLQDLFISMSTTGQSIESLPVAFVKFLKSTLEIDHSYMLDLVSGLDTNLKDLIRGHAEEEILRFSAFLCDINLDDKDGNCLDELPFVHRLLDVICATTTSNAREAQSSLLAPLVERLKGIAELLHQMDYRLMKRDEQATIENNLLPSDLCSWLNALLRLVVCQSPGLIPKANHQHQAALMWNLRNLLTHPHLQGFPSTTQYIFDVSVLLSDHISEEVRKNLVSSTSTKSSYDSRCAFIFGLEPHEDGWLGLTRSLQRASSPQRQTPASNPAQPQIQGQQQYGVGAAQSRRPSNTPQNQPQGRYPQQQQPHNILSQQLQRMGSNGQNSPVSQLQQMQQMQAMAQQRQNTMSPQLQRTPSMQNQPPRATKASGVKQERVDAKPVPYKLSRWEVLPESGSNAGGSGNETAISLSLFGARKA
Length1567
PositionKinase
OrganismParaphaeosphaeria sporulosa
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Didymosphaeriaceae> Paraphaeosphaeria.
Aromaticity0.06
Grand average of hydropathy-0.253
Instability index50.91
Isoelectric point8.33
Molecular weight174361.91
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07561
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     128.38|      20|      21|    1464|    1483|       1
---------------------------------------------------------------------------
 1402- 1428 (26.03/11.26)	RSLQRASSPQRQTP...ASnpaqpqiQGQQ
 1435- 1457 (31.10/14.91)	AQSRRPSNTPQNQPqgrYP.......QQQQ
 1464- 1483 (36.86/19.07)	QQLQRMGSNGQNSP...VS.......QLQQ
 1485- 1504 (34.40/17.29)	QQMQAMAQQRQNTM...SP.......QLQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.30|      25|      25|     123|     147|       3
---------------------------------------------------------------------------
  123-  147 (41.46/34.44)	PGGSGVKADPTVTKVVNQETPASAA
  150-  172 (40.66/33.58)	PGGKAADFFPWTGS..HPEDVLSEA
  175-  191 (21.18/12.79)	KGGISNK.....SQIMNETNTA...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     886.26|     163|     181|     881|    1043|       4
---------------------------------------------------------------------------
  360-  521 (137.15/76.34)	...........................E..DHFMDWILKS....LD..SCSSERLFlwllitciPDfwTSLISF.RRRG......KRLAESLLnHAGKIystsgeSRET.....SVLGLLESIIARVAVTK...SA.....C.LLLPDD...WE..KCKVVLYVFAQRRAHA..........KIS......Q.VIPGLD...QRNR..DIM.PSrslgssasqrSYrvLYQF.LDGVDY.......ETNI........SVDE
  533-  691 (169.98/96.47)	HD....RLISAV.L....QWS...SSLY..RQGLHRVY.LATRLLR..KWNHLGID........VS..EGILRY.LPRL.......ALDPSK..DAELV......FRVV.....S...............ELVRSR.....T.FSLGRF...LQwlIATGSMDPGQDHHAAI..........AWQlrllteV.PLSGLSEQV..LNLRSTM.LR..........GS..VYSVDTEDDLI.L....NTQDSilqqltdfTLTD
  692-  835 (117.74/64.44)	P.....NGLRRMtL....NIGrlsRTMC..LEVAIWLRRQVAATIE..TSDRAPTK........ES..SIFMAGsVCTI......SS...SCF.E.IVR......HYLEqfkdlSILADVVG.ISATSFDAHILGAsadtlC.YHFKAF..kAI..GAFNPLSEKIVMRYTQ..........IRA......I.R.......LP..ERSLLL.SI..........SA..L.................................
  881- 1043 (263.20/153.62)	PE....DEIERI.L....SSG...NSMD..QHTMNRVFKKVVAYLD..QRSSQGSY........PS..EGLLSW.FCRL......QSLEENTF.HAIVV......SWLQ.....SVLTDQEPRILAVALPPLVVSG.....C.LSLSRF...AE..TTRDYMRRLQPNHFVE..........SFR......V.AINGLDIILPRHELSDLL.PH..........SY..LYQFRTKQVAF.C....QKQDS........GLLE
 1056- 1231 (149.64/84.00)	PDlcsgDSLPHV.L....SDG...RLLGvlRHSAAVDFQNVSFLLDcsARITSG.V........SQ..TGIKSL.LDRI......M....DPL.NALDL......SRLS.....H..EEQATAIFRYA.DQLSLSF.....CqLKLQDLfisMS..TTGQSIESL.PVAFVKflkstleidhSYM......LdLVSGLDT.....NLKDLIrGH..........AE..EEILRFS..AFlCdinlDDKDG........NCLD
 1232- 1317 (48.55/22.03)	EL....PFVHRL.LdvicATT...TSNA..REAQSSLLAPLVERL.......KG..........IA..ELLHQM.DYRLmkrdeqATIENNLL.PSDLC......SWLN.....ALL.....RLVVCQSPGLI.................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.79|      27|      47|     264|     290|       5
---------------------------------------------------------------------------
  243-  263 (25.69/12.48)	........TRETWLHDLANPTV.GLRRLSR
  264-  290 (48.95/30.94)	TIP..HGITGKVLLDQCLNKNI.PIPRALW
  311-  338 (34.15/19.20)	TITwvRGWTSSV..EQFLDGVIsTIGQQDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.65|      22|      29|      60|      85|       7
---------------------------------------------------------------------------
   60-   85 (30.87/27.19)	GIQTTATEP....MRVPPkgKPQLffSVAA
   88-  113 (36.78/18.53)	GLESSEPSPttaaLPVPP..RPSL..SMPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.55|      25|      33|    1333|    1361|       8
---------------------------------------------------------------------------
 1333- 1361 (40.79/35.22)	RNLLTHPHLQ.GFPSTTQYIFDvsvlLSDH
 1368- 1393 (39.76/24.73)	KNLVSSTSTKsSYDSRCAFIFG....LEPH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07561 with Med12 domain of Kingdom Fungi
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