<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07557

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDSLVKEWALFLDRCLENRIDIDLFAAAATQLHTRSPLPGHKLAALLVKPRAAGLNSVDPRVIVYAERLLALKKVDASDILAAAFQFSKDRPIQSSDNTNPKDPSRWQNPSELDEILFHRLHKAFSGERPERPASNAEGTRTVKAAIRWMSAMVASHTNDSMLQAMAGIQQQPQQQSINVREGLGMLVVGLIENVKILQLLNRDELKDIRKAFARALTTFIPFLSQTSIQIANRLEIYQKEHDFHDKSSAGQTNENAGLEVAALQLEAVIDLPQINTRAGLYIFLNALLIARPLTDDIIINNYLHSFYKMDAQNMATDLVTASFDILANAMYRSESTQTMTSLKSFLVNKVPTLLTQLTAPLYAMNPELCITQAFSRIDPNAFPAFSQGFDDMLGNNSSLADVRQDFLNACALHNLIPANTVERLLGEAPMQGPPATRYVKQDLLKQCKDNIDKATAYIEELENLDGNAGAIVAALVDFVAHLCETQMTMYLKTLCNTLSKKTTALDVILQFTSPASILRPLCQFLDEWHYETDQEYQPVYDEFSAILVLVLAFVYRYELTYNDLGIGHDSFVARLLERGHRSISSNDLTEEQGNHLGGWLKGLFDADKEGLSNDVFASCRPQEFYLIVPTLFNQTAMACSVDVLSLDSVKGGLEYLHETFLLPSLVGGLTWMASHALTQTHQDHDVMVQIFHKLIRSAPTSGDAQAMHSTILSIVSARLETCFRTLKRRYSGYSTDMDQLLEAIKPSLHYVRSVSSPTSELEQWTTATNNTLASSLRHTVQQLSQWATNASIQPNPPSYTHRQLYTCIDLLGTQQTLRAIIDEVKAQTDAGNGAAALDIGVSLICAPMITDSVLPVEWAGCSAPAPQPPRTQSNLREMLKDEFDNAASFVSTDPSAAEAVVRLHRRVEAQLAVIAQAGLSTANVDLSNVGMVQAPSLTTDLDKAMNDAAAASIAAVGADLTDLNKQLQQNIDQELDLGDAGAGLDLSGMVVDGNTGGISADMGNLPGLDLDMGDMSMNMDMEGDDDWGLDFGGM
Length1035
PositionTail
OrganismParaphaeosphaeria sporulosa
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Didymosphaeriaceae> Paraphaeosphaeria.
Aromaticity0.07
Grand average of hydropathy-0.112
Instability index38.95
Isoelectric point4.86
Molecular weight113632.64
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07557
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.01|      14|      71|     786|     805|       1
---------------------------------------------------------------------------
  786-  799 (27.17/11.29)	QWATNASIQPNPPS
  858-  871 (27.84/11.94)	EWAGCSAPAPQPPR
  883-  896 (22.00/10.04)	EFDNAASFVSTDPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.51|      20|      26|     511|     536|       2
---------------------------------------------------------------------------
  511-  532 (34.29/36.66)	Q..FTSPASILRPLCQFLdeWHYE
  538-  559 (29.22/13.26)	QpvYDEFSAILVLVLAFV..YRYE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.08|      35|      94|     155|     192|       3
---------------------------------------------------------------------------
  155-  192 (56.26/47.22)	ASHTNDSMLQAMAGIQQQ.....PQqqsINVREGLGMLVVGLI
  250-  289 (52.81/35.73)	AGQTNENAGLEVAALQLEavidlPQ...INTRAGLYIFLNALL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.91|      27|      34|     964|     997|       4
---------------------------------------------------------------------------
  964-  990 (49.20/34.63)	LNKQLQQNIDQELDLGDAGAGLDLSGM
  999- 1017 (24.39/ 7.45)	ISADMGNLPGLDLDMGDMS........
 1019- 1035 (29.32/ 8.07)	.......NMDME...GDDDWGLDFGGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.24|      54|      69|     305|     362|       5
---------------------------------------------------------------------------
  305-  362 (80.81/61.39)	HSFYKMDAQnmATDLVTASF.DILANAMYRSESTQTM...TSLKSFL.VNKVPTLLTQltAPL
  373-  431 (80.43/49.17)	QAFSRIDPN..AFPAFSQGFdDMLGNNSSLADVRQDFlnaCALHNLIpANTVERLLGE..APM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.71|      24|      27|     604|     627|       6
---------------------------------------------------------------------------
  604-  627 (43.36/22.33)	LFDADKEGLSNDVFA..SCRPQEFYL
  632-  657 (36.35/17.80)	LFNQTAMACSVDVLSldSVKGGLEYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.73|      23|      86|     827|     851|       7
---------------------------------------------------------------------------
  827-  851 (36.21/30.89)	AQtdAGNGAAALDI.GVSLICAPMIT
  916-  939 (35.51/22.91)	AQ..AGLSTANVDLsNVGMVQAPSLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.41|      40|     233|     467|     510|       8
---------------------------------------------------------------------------
  467-  510 (60.49/46.97)	GNAGAIVAALVDFVAHLCETqmtmYLKTLCNTLSKKTTALDVIL
  703-  742 (68.92/43.20)	GDAQAMHSTILSIVSARLET....CFRTLKRRYSGYSTDMDQLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07557 with Med5 domain of Kingdom Fungi
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