<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07551

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLKTCNTNAQAIGDFEAVAYQAFSVARNPARSSSSTLDWNPSDDIRVAEAELRSAHHIVLHDAARAWLWLFRPAAPDHVAQPPLDPPALDDFRLNREQHGVVKAHELEQRSARNPRNAPPSAASNSPVTPRPQKAIHGGAAQQSQGGAPLVTSDQPQHDVVAIYGLFTSAVVALISFHLVKDYNAIALNYRTFASSSVLSRDSGFRHASPRPPLRITNVDVAWASAGTLVVSTFSLTRSDMHCLADITPDDEQKRLVGKCVRVAPNGILAKVMSFTDPVDTTADDAGQKPQRKRPRFSPLEKSIERWKSSVKRWLSWKGYSIPLLDNKDSWVRIQFAHMGQAVASSPAFSRPAREVLWPRALCFCFLESPNDAHLLTSHEELPLQDADALAWFETPYNKGYQDPIDVAQQWFLGKTERDRIAEAHRKAKKAEEDATRAKEENHGLFPSSPLNARTGTYGDLHSVSGVYPTPPDGVPPGTVISCGDTPSVSGLATNVILAPGGNNPAINVSVPQDSTSGESQQQASTSPNFDLQFEGYQTDGNNDDLFEDMDEGTFDEGNGVTDADFNFFDDADGEDVIMPDAPPTVKTEPAPQEEAAMKDEPLDPMAALEFALASASAEPEQGTQHEESGYVPLKLEVAALDSAIPESSHLSNSGLQAVAPTPEMTTPPLSPRFIETALLPSPKLKTPQKQLSTHHRDSVFGSLNFSRKMSLSDAKYKAGRFMSISERSTKLDGTDNTHRPKSLRDLPLMTKLRYAIGVASATGNIVGSPQDVSDSEDSDASSESSSESEEEVNDVVPMPFVGNIIIPIKRKLPTESVATPMSAASFADSFGGDFSELIGLQTDESALVVLEPTIFDWSLLHLPPPTELAFSGARWALPAFPYAYSSVPSTPTSQPDLSMNLIEEKALSGKDRIAIAQIVTDQIASATLDLLQQGHGSECSKEQPSESIWHSAIKTIFPNATECSVAGLAAVQDVFPDSLTQMKAQQRPPPRRPNEAATALGHHMFPLNPPYVRVKRADTLWDLLPPAIPFWETLGLGPCSPSKNVMALSIYPHSSALKPCVEGFLVNMQLAYDGCKLGNHSRADALTEYPNGLVPCKIGAGASLRTTFKALRDTCVQLSKVLAAKHAQMRDKDDSRIDAFVIYMIDPFEQAPAIWELCSAFWSLFQSYQQPPSRTEVQKPDLVLQIVPIRYIASFEAPVILDSNIYTALAREVYDRCPPSAPSEDKLPLSIYSAPSFQLEEPIPRNIQFKLMADTPQDLMRENSYMHIGYAISLDGTWVTAAWSDTCGKSQAVVSYNLGTRAFADIAREIWQTTIEIIQVRRVMWRVCIAKAGVMEREELEAWVFLVQCPAVLNLFTTLMTIDTEPHLKFTPTMPPPSASANPATHTPGSTPQAVVSPEQGLTPAATPAVDTAADPAADPDARLVDMTDETWGIILAHRLHNSNSTNEYRPALISGLLVKRGLAPGLSAPPLAPDAQPGPLITAVNILWMGTVNSTRVAASPFPSSAADASSPAAAAPASPSPQEPRSNSLAWTPTPQTRGAAENLMKEVLGQFRGLGLLARLKGVQGARHGSVPWHVAVALRGVRGLSRTVPC
Length1597
PositionKinase
OrganismParaphaeosphaeria sporulosa
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Didymosphaeriaceae> Paraphaeosphaeria.
Aromaticity0.07
Grand average of hydropathy-0.280
Instability index52.17
Isoelectric point5.28
Molecular weight173238.28
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP07551
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.56|      41|     129|    1378|    1418|       1
---------------------------------------------------------------------------
 1378- 1418 (74.12/38.01)	PPPSASANPA..THTPGS.TPQ...AVVSP...EQGLTP.................................AATPAVDTAAD
 1431- 1512 (35.49/13.79)	TDETWGIILAhrLHNSNS.TNEyrpALISGllvKRGLAPglsapplapdaqpgplitavnilwmgtvnstrvAASPFPSSAAD
 1515- 1547 (43.96/19.10)	.......SPA..AAAPASpSPQ...EPRSN...SLAWTP...................................TPQTRGAAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.32|      17|      17|     654|     670|       2
---------------------------------------------------------------------------
  654-  670 (29.82/15.89)	SNSGLQ.AVAPTPEMTTP
  673-  690 (25.49/12.31)	SPRFIEtALLPSPKLKTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.51|      26|     129|    1018|    1046|       3
---------------------------------------------------------------------------
 1018- 1046 (45.14/25.45)	KRADTLWDLLPpaiPFWETLGLGPCSPSK
 1152- 1177 (49.37/21.43)	EQAPAIWELCS...AFWSLFQSYQQPPSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     220.18|      68|     129|     816|     890|       4
---------------------------------------------------------------------------
  816-  890 (111.25/73.30)	PTESVATPMSAASFADSF.GGDFSELIGLQTDESALVVLEPTIFdwsllhlPPPTELAFSGARWALPAFPYAYSSV
  917-  985 (108.92/58.92)	AIAQIVTDQIASATLDLLqQGHGSECSKEQPSESIWHSAIKTIF.......PNATECSVAGLAAVQDVFPDSLTQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.94|      12|      16|    1566|    1578|       5
---------------------------------------------------------------------------
 1566- 1578 (18.09/15.31)	LKGVQGARHgSVP
 1585- 1596 (21.85/12.63)	LRGVRGLSR.TVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.55|      14|      16|     572|     585|       6
---------------------------------------------------------------------------
  572-  585 (25.88/14.38)	DDADGEDVIMPDAP
  591-  604 (25.67/14.20)	EPAPQEEAAMKDEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.17|      11|      21|     299|     309|       8
---------------------------------------------------------------------------
  299-  309 (20.96/11.26)	FS.PLEKSIERW
  322-  333 (17.21/ 7.90)	YSiPLLDNKDSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.42|      16|      20|     471|     489|       9
---------------------------------------------------------------------------
  460-  483 (24.92/ 7.14)	YGDlhsvsgvyPT...PPDGVPPGTVI
  485-  511 (16.50/ 9.55)	CGDtpsvsglaTNvilAPGGNNPAINV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.15|      28|     249|     359|     386|      10
---------------------------------------------------------------------------
  359-  386 (54.30/32.24)	LWP.RALCFCFLESPNDAHLLTSHEE...LPL
  605-  636 (38.84/20.82)	LDPmAALEFALASASAEPEQGTQHEEsgyVPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.47|      12|     251|    1221|    1232|      11
---------------------------------------------------------------------------
 1221- 1232 (22.81/ 7.31)	PPSAPSEDKLPL
 1473- 1484 (26.66/ 9.79)	PPLAPDAQPGPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.91|      15|     923|      75|      89|      12
---------------------------------------------------------------------------
   75-   89 (31.30/15.27)	PAAPDHVAQP......PLDPP
  993- 1013 (23.61/ 9.44)	PRRPNEAATAlghhmfPLNPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.23|      19|     378|      48|      68|      13
---------------------------------------------------------------------------
   48-   68 (24.76/26.03)	RVAEAElRSAHHiVLHDAARA
  422-  440 (32.47/22.12)	RIAEAH.RKAKK.AEEDATRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.90|      18|     252|     514|     531|      15
---------------------------------------------------------------------------
  514-  531 (32.53/20.65)	PQD.STSGESQQQASTSPN
  772-  790 (26.37/15.08)	PQDvSDSEDSDASSESSSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.53|      15|     252|    1096|    1117|      16
---------------------------------------------------------------------------
 1078- 1094 (22.52/12.89)	CKLGnhSRADALTEYPN
 1099- 1113 (26.01/16.53)	CKIG..AGASLRTTFKA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07551 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AEAHRKAKKAEEDATRAKEENHGLFPSSPLN
2) ASPFPSSAADASSPAAAAPASPSPQEPRSNSLAWTPTPQT
3) DSAIPESSHLSNSGLQAVAPTPEMTTPPLSPRFIETALLPSPKLKTPQKQLSTHHRDS
4) GLATNVILAPGGNNPAINVSVPQDSTSGESQQQASTSPNFDLQFEGYQTDGNNDDLFEDMDEGTFDEGNGVTDADFNFFDDADGEDVIMPDAPPTVKTEPAPQEEAAMKDEPLDPMAALEFALASASAEPEQGTQHEESGYVP
5) GTYGDLHSVSGVYPTPPDGVPPGTVISCGDT
6) GVVKAHELEQRSARNPRNAPPSAASNSPVTPRPQKAIHGGAAQQSQGGAPLVT
7) HLKFTPTMPPPSASANPATHTPGSTPQAVVSPEQGLTPAATPAVDTAADPAADPDARL
424
1503
644
493
458
102
1370
454
1542
701
635
488
154
1427










Molecular Recognition Features






MoRF SequenceStartStop




1) FEDMDE
2) LQFEGYQ
549
534
554
540