<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07549

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGILKMNTSANGGLGARDVESRKRAHDGNMVNGERTLVRKDSPASAPAVRTPSYNGADTNGATSAVKQMAQLPPEIDHVPAEVYHSLSKLIQRISQETYNELSETLMQMRELKAPQFNGNVPNGNAPPTPQDVEISKQKKLLLMRFALDNRAKFIKLLVLTEWGRKASVDLSKLIDLFTWAVKQRASQDQISDQIEFMKYVMNDARQLNPDITTALEILGTGKAEWIPDMGFIPPPPMTAEKALKLLRYLNVSLSTRLIVHEKLPHQLSKWRIGDGRVTFIMDDEFEFDLMSFVEDSSDQFHFVDMRLLFSPAPVISADSRFFNRLRTGVDNLLREKGLEVCFGYLLNITLSHKIFILSSQVNDLLRTGWAGSLRSEFAHRVLWIQYWTNRPGKKSWIEIGVASNKSKDGKVSWRGPPIPSIIVRWFREGVHVQDVDLGFDWTHLSVERMMKRVIALHVGHLLRNMQQAFSTNVITKASLSDTEPSDCRLAVSIGSKEHTTNLSIEPITGRYTLSPATPLSTPAENAINRSHEPAATSNTITQVLARSILESIQRYSQQLGWQSVARQALRMEVVRAAVNLDVLRFTLFWPRGWSTTTALAAIVDATGESWWICEIGDKGSTIVHAQRIAVECIDGRPPPINRPTLSRIERVAVHQLAYSITARALRQAGKTYSLRHEIESSRRPASSDGVVRGWALYVRTPELLSSQTGDDSWLEPAMQITGHGFRSDYRNVWHIATGTMVPEVAADMQKLMAASPQTNFTFSEGGKFSILLSTPFGHEVVSELKARLRDLNRLRSFATTLEKRKMMLKSSSLEQVEFQYSQGLSVKVFFGKGTDIRVKFGDKNPHNRIHSFLTDMINDRSPGLPQPSPGDNNGLDRFCAALIWSRPLLTVLSELENRTPGNVDNPAVHVHDLRTYRITYTNPPCSFDIRLKPKDDRVLWDIEDNEGKPADLRPKTERSPNFKRLETLKSALQKLFRERDERWWGVRTGIIADIDGVPDALRKLNEVVIGCYVEGGVKQEAADSNAPITAAAPARQPNSSNPANRPNGNAAANVKKLPAGRGGGKNHEVITID
Length1075
PositionTail
OrganismParaphaeosphaeria sporulosa
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Massarineae> Didymosphaeriaceae> Paraphaeosphaeria.
Aromaticity0.07
Grand average of hydropathy-0.374
Instability index39.49
Isoelectric point9.31
Molecular weight120333.85
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07549
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.34|      15|      16|     157|     171|       1
---------------------------------------------------------------------------
  157-  171 (26.48/14.76)	KLLVLTEWG..RKASVD
  174-  190 (22.86/11.82)	KLIDLFTWAvkQRASQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.49|      23|      39|     327|     349|       2
---------------------------------------------------------------------------
  327-  349 (41.58/27.03)	LRTGVDNLLR.EKGLEVCF.GYLLN
  367-  391 (37.91/23.97)	LRTGWAGSLRsEFAHRVLWiQYWTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.75|      35|      37|     660|     696|       3
---------------------------------------------------------------------------
  660-  696 (55.67/33.70)	YSITARAL.RQAGKTYSLRHEIESSRRPASSDgvVRG.W
  699-  735 (57.08/29.26)	YVRTPELLsSQTGDDSWLEPAMQITGHGFRSD..YRNvW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.83|      14|      21|     924|     939|       4
---------------------------------------------------------------------------
  924-  939 (24.38/18.78)	NPPCSFDIRlkPKDDR
  947-  960 (25.45/13.32)	NEGKPADLR..PKTER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.63|      10|      19|     485|     494|       6
---------------------------------------------------------------------------
  485-  494 (18.39/12.04)	EPSDCRLAVS
  507-  516 (18.24/11.88)	EPITGRYTLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     212.00|      72|     557|     218|     326|       7
---------------------------------------------------------------------------
  115-  152 (37.55/ 9.78)	APQFNGN...............VPN.GNAPPTPQDVEiskqKKLLLMRF...ALDNR...........................................
  206-  297 (104.91/112.83)	ARQLNPDittaleilgtgkaewIPDmGFIPPPPMTAE....KALKLLRYlNVSLSTRliVHEKLPHQLS.KWRIGDG...RVTFiMDDEFEFDLMSFVED
  802-  857 (69.54/27.83)	..................................TLE....KRKMMLK..SSSLEQ...VEFQYSQGLSvKVFFGKGtdiRVKF.GDKNPHNRIHSFLTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.24|      10|      21|     623|     632|       9
---------------------------------------------------------------------------
  623-  632 (16.56/11.52)	TIVHAQRIAV
  646-  655 (15.68/10.51)	TLSRIERVAV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07549 with Med14 domain of Kingdom Fungi
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