<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07533

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDDKTQISTEVNGYGKQQQHLPQTNNGFDDTNGTHINSNKEQQRPLVNGDNTPVPKKIVLPVEMASMVPLRTLVGKMIHKAHADLMTLTDTLPSMSDVERKRQILNYTTFTRKQFLKLTVLMKWAENADDIQMCQNVMSFLANQNRTFQDTVDWLHRIHIDLPGTRVRNFDILTAVDVLSTGTYQKMPTKIEDMLPPTPLTDRQVLETFEKMNDDIRVRMLTKEVLPSTMQEYRIENGRVYFYVNNEFEVALTLMGNSNDRKWWIVSLDVLVQPSSDGSASDVDISLNDIQRQRLRSNAQRQLVPPETPSTNTEQSVTNSPFDSTDKETKPSTEQQPSNNANQLFFPLVNLYDYLHLFCLNMQLEVVYMQATMMAKSRWLDQLKVHMNPTRTSLTLIYWGGGSATAQWGSPQNIDQGSQQHARSTSIEISVRNEDSRLGKQTVASSRALSIAVRDEYKGLIQKCGIGASVSLADLDEVSKTKVYNSLKYPKTSLDILWSGDSDLHTKETLLNPTDMNVERLISHVTTYHKQSILTKFRQLLKSEASFLKDNGLTLMDDTTESSDFDSRVGRVKVYETEKNGGDGNVKLGGLEDRLNTDPSNIGRHLLWLRSGVVVHEIVSLAKQLNLQPFHPSQMHLRSDDMLKLFGDLPGVSPEPIDLSSSKKRLLQQQGVPSSSASVTSSSSASSTPARRTGADQSQLPSTKPSYPQHCVFLQFSQFEDWYLVITVIRNEFQPSLCCLKKTSDQNAIYQEFVDLIHVDHDQVWKERFISGRNDLVDLESDLTKHQNGEPNSGTDEFDAGGHSAKRRRTLTGLEIVPEPSKSPSDKVDKAFITNRKIELQLHQYRTIRSYTRPFIKSFSGKESGTISHPSADRMEVLCISQSDLLKTCAYRNVDMVVPPGNPGAAGAVTGATRIDLIAWVDSIAPRMTNEVMLRASGWWTRGRKQCFVEIQDKVDWSTIPLRSNDLSDHISLDSNSSVLSFTYSNIDSCVDRFLTDWERVFMMANLSRQVSSLWFKKYQDQLTFEPCDMQKLTFTYAKDFVCTIRWGSPNKGQSRRYIVDVGTSQGSTPNSGNNTNTIMHPVNHLRSSVKWNPHWRVISFLQDILNDKRDLVYFVQILFQTLPLMACLQQLESDCTQKGDMGRVCIIPRASDSVRIMFSYLHGVDIRFHGPSTICITDAAFHHTIYRTLQHTSTAKPMAPPPPYIPPSAPTTADQQQQQQQEKGSMEPTNDSIKKNTIAPVSVSQQVICKPFAEFDKVLEDVDQWIFVAPDTRSLEDSVMDGIKVEDGEPQPRQQPWYLSGQYCWQDTSEPSVVPFDHGLLCSASLCRNVLLKLQHFCLSDSPVA
Length1346
PositionTail
OrganismAbsidia glauca (Pin mould)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Cunninghamellaceae> Absidia.
Aromaticity0.08
Grand average of hydropathy-0.483
Instability index48.34
Isoelectric point6.21
Molecular weight152151.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07533
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.71|      50|     107|     176|     231|       1
---------------------------------------------------------------------------
  176-  231 (80.82/59.96)	VDV.LSTGTYQKMPTKIE.DMLPP.TPLTDRQVLETFEKMNDdirvrmLTKEVLPSTMQ
  283-  335 (72.89/42.42)	VDIsLNDIQRQRLRSNAQrQLVPPeTPSTNTEQSVTNSPFDS......TDKETKPSTEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.94|      57|     498|     701|     791|       2
---------------------------------------------------------------------------
   93-  156 (81.51/33.25)	PSMSDVERKRQI.LNYTTFtRKQFLKLTVLmkwaENADDIQMCqnVMSFLANQNRTFQDTVDWLH
  701-  758 (99.43/101.45)	PSTKPSYPQHCVfLQFSQF.EDWYLVITVI....RNEFQPSLC..CLKKTSDQNAIYQEFVDLIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.98|      11|     211|     860|     870|       3
---------------------------------------------------------------------------
  860-  870 (21.35/13.61)	SGKESGTISHP
 1072- 1082 (22.63/14.91)	SGNNTNTIMHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.27|      29|     498|     760|     791|       4
---------------------------------------------------------------------------
  760-  791 (45.70/39.82)	DHDQvWKerFIS.GRNDLVDLESDLTKHQNGEP
 1262- 1291 (48.57/30.82)	DVDQ.WI..FVApDTRSLEDSVMDGIKVEDGEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.55|      27|     223|     249|     277|      10
---------------------------------------------------------------------------
  249-  277 (44.70/38.18)	EVALTLMGNSndRKWWIVSLDVLVQPSSD
  477-  503 (48.85/34.15)	EVSKTKVYNS..LKYPKTSLDILWSGDSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.49|      57|     610|     340|     398|      11
---------------------------------------------------------------------------
  340-  398 (98.00/69.48)	NANQLFFPLVNLYDYLHLFCLNMqlEVVYMQATM..MAKSRWLD..QLKVHMNP.TRTSLTLIY
  976- 1037 (88.49/56.67)	NSSVLSFTYSNIDSCVDRFLTDW..ERVFMMANLsrQVSSLWFKkyQDQLTFEPcDMQKLTFTY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07533 with Med14 domain of Kingdom Fungi
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