<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07530

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSVGSDFGEVSYGEMLRSEQTDTGDNQPPVQLSLPHKTLKQVRVTIRRNKLSQPGACSVGILGLGTADENEDETDIQDVCPTLHKAHDSSVQRRLIDAQSTVYDAELFSRILSEAQVIPSNIQCEEDCVIVTLDGQVDILIQKSQCDEGLKQQPDDSPSTTMTASPQQLTGQTIEMALRLLLVQRHRLNLWKSRTRLMSGQRKTQQLLNAMGDTTILPGLATGSTGNTTLINSTMASGPGGPGSSGSKSTATGGGSSSGGGGVGSGGGSSTPILSHRSTVNPSATGGVSSVSSSSLTASSSASMTRQMTGGGGSPHSSRDPHSEVPLLSPVVSMARFWVQFDRIRQVVHTAVDPLCGESGLGLTVHFKPQHVFNNAPHGYCDAYPGFGELAMTLANVTEFESFLLREINLICLHQVCDIANGLVRRSPAYQAAKSNERGSYLWQVDEVEEILYGTVNTAKKLDPPVWKTIQVQLNQTKINQKMPAYVLQFKEDTSHHEQHRSRHPIKRFILLSQWQDIDRDTVKCSVGFREKVAMMVQQLLE
Length542
PositionHead
OrganismAbsidia glauca (Pin mould)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Cunninghamellaceae> Absidia.
Aromaticity0.05
Grand average of hydropathy-0.362
Instability index51.41
Isoelectric point6.25
Molecular weight58709.43
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07530
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     113.44|      23|      23|     240|     262|       1
---------------------------------------------------------------------------
  223-  242 (30.19/13.70)	GSTG.NTTLINSTMA....S......G...pGGP
  243-  262 (32.23/15.14)	GSSGSKSTATGGGSS....S......GGGG....
  264-  287 (24.83/ 9.89)	GSGGGSSTPILSHRStvnpS......ATGG....
  289-  315 (26.19/10.85)	.SSVSSSSLTASSSA....SmtrqmtGGG..GSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.08|      11|      19|     123|     138|       2
---------------------------------------------------------------------------
  123-  138 (15.55/18.16)	QCEEDcvivtLDGQVD
  145-  155 (22.53/11.55)	QCDEG.....LKQQPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.33|      23|      24|     339|     362|       3
---------------------------------------------------------------------------
  339-  362 (36.88/28.14)	VQFdRIRQVVHTAVDPLCGE.SGLG
  365-  388 (42.44/27.44)	VHF.KPQHVFNNAPHGYCDAyPGFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.44|      16|     182|     316|     338|       6
---------------------------------------------------------------------------
  316-  338 (26.15/30.30)	HSSRDPHSEVPLLSPvvsmarfW
  500-  515 (32.28/19.50)	HRSRHPIKRFILLSQ.......W
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07530 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QRKTQQLLNAMGDTTILPGLATGSTGNTTLINSTMASGPGGPGSSGSKSTATGGGSSSGGGGVGSGGGSSTPILSHRSTVNPSATGGVSSVSSSSLTASSSASMTRQMTGGGGSPHSSRDPHSEVP
201
326










Molecular Recognition Features






MoRF SequenceStartStop




1) YGEML
12
16