<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07528

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLSDSSLTNILTVSGVSQIRYRAYQQCYSRSLLTTCFTWLDPSASPKNPTTLITAYIQLINQNIPCMWQLQPSAKPSAPSSKMDAQADSVTLELWVFWFDDRHTGLIDSNTLLKELEELRMGSFTWENVSSKNTHRSNACTLVTVVVEYKLFVKAIRNLIVPYMLKKDALPLGEFFIFPLSYLEPAVGEEENDPNQTSSLLCCTYNIYLASTNLIFQPSTRRIRLRPLIPSDLHSTATTKGAKEKGLDVSVISYVSQCVVLLSPSGEYAYLLPSNRDTTHPMETQVLKQWSALLHIPLTNLTSTSAAIPSLVLIRMTWGGNVYYPSRLVFALTPTRQSPSALAGMNGTLGYNHGLTEDIAQKWSREMWLEQVLANQGDKTKNKVDYWSYTSPRLHTTLAALDSISASTMNTQNSMDGNSPMMVQGGLLMKALKEPVLSSPLMASKSVATPCSPLPKDDGDDDNEKTHGSTNGDTPGGSSNIGTNSIGWRGNQTSLADFVQQYFNNGSVDDLTMQLNGSMDGGLLSRSTSTPSSATLVMAPTSHQHQQQDSMMMATGQNYQTPNMIQQQQQQQQQSPYNYSAPAYMTPGTNYTSPLQASYSASPYQNIPTQQQLQNQQQQQHLEQHQQQLQLNDLNQPQQQQQQQQQQQQPMAAHIDKSQVMDEGMNGGGTDVNAMDALDTMGYDMSTPWGGDGGLDNLELDLDVTEEDFNFFESEPAKPTTTSIPQGQPLSNMQSMDAFFSTKNEDSMPSDMMLDSLQYTGTEPTPALDTHMTDLLATPNYDGMILDSPKRELYQDPDVPTESSPALLQDAPAAIDMDIKQEIQDVIPSSALATLPVTSAPSDNIYQRNTSLASGYHASWPAVATGGADKEQRLVPPSFAPLTLPTPVNDAKYMDGGKFTYTPGDDRDDDKDVAMGIFSFGNSTKATPAKRRKPKDRSYRPDYVPIVKKKRNKKKTSGDGDDDGRMAVTTSDQPDNTTLIAPNHAVDDDGDAMMDHVSDNVNKNSSNGDSSDEDSSSSSSSHDNSDSDSEDSGMTSDGDISNNNDFKVVGTLLKRSPSSSTTTTTPGQDQRKEKDGGNDTEDSESTSRQSLTSMTTAADGYATGGGGGFSAGEHDAGLENGSSHWSENLVKARSVYLHRLIGDVRISHGGKRRYLLDRLDIDYDTPFAASVVPGLAHPERYHDEDERALHYLCQQAVLGGYPFAGGLAEISTNGGEVPLGESARVMITRRRDLIQHARGVTSHVPCLPCDFDRVTQDFKSILNDIFDPKATATDEPLPLNVTDFTSSVSVNGPLNVQQYYELSESNQIHSKYGKYQVKKRRPAEPNFDTLHSPDIMVGRNDEFIEGSPKMIDFWDKLRLEPYSAKKNISYFVVCPKNEELESAVHVFFKGLSTVYETCRLGAHHPGHIGPYRRGTVPVPSLPEEQGQSKKDRQLKSYMATCEQLGTSLGGVMAENVYIVIYMVNPLPHLSSHMDLSKCYNKLMTAFEQARSQHTSAPIITGPPGTARFPSEKTRARLVMQIVPIEHILRCTDFGSYTKNGLKEIAFSVYSKCPTVVNSHSKRIRDQKNSAATNPTISATTDIYAPPFVLTKDVPDHVAFSLSPSLNAPVILDQDATLHLAYGYSLDRRWMVVVWTDHRGELVEFAVLRASARQSAPFVAVFEEAWRRTKEIADQTDFVWTFVIVKLGLMFENELQAWIHVLPENERAAVVSMDMESSLHVDSSDVQEEPIQYYAPDTPQTPQTPNVGPNHVSTPPPTPQQASSTSTPSASAASTSKNSSSSIDTLDTATATTTTKILLLNHRVAYSRKRQRISEGVTLMDAVSDSESWILPLASGYLIQLPKQRAPTTASEEQFGRAPCVVELHLVYNQTQHSSYTTLRDIIKRYYALSYVNVVPSAYNCLPIHIVLAQRLWRLLLVVNY
Length1920
PositionKinase
OrganismAbsidia glauca (Pin mould)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Cunninghamellaceae> Absidia.
Aromaticity0.07
Grand average of hydropathy-0.502
Instability index50.56
Isoelectric point5.25
Molecular weight211817.20
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07528
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.53|      19|      19|     610|     628|       1
---------------------------------------------------------------------------
  612-  628 (30.32/16.54)	QLQ..NQQQQQHLEQHQQQ..
  630-  642 (17.67/ 6.15)	QLNdlNQPQQQ........QQ
  643-  659 (26.53/13.42)	..Q..QQQQQQPMAAHIDKSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.51|      16|      24|     543|     563|       2
---------------------------------------------------------------------------
  543-  563 (27.24/22.83)	HQHQQQDSmmmatGQNYQTPN
  568-  583 (31.27/14.60)	QQQQQQQS.....PYNYSAPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      91.72|      18|      23|     999|    1016|       3
---------------------------------------------------------------------------
  921-  938 (21.04/ 6.61)	GNSTKAT.PAKRRKPKDRS
  949-  965 (22.70/ 7.68)	KKRNKKK.TSGDG.DDDGR
  999- 1016 (27.31/10.67)	DNVNKNS.SNGDSSDEDSS
 1023- 1041 (20.66/ 6.36)	DNSDSDSeDSGMTSDGDIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.64|      19|      22|     667|     685|       4
---------------------------------------------------------------------------
  667-  685 (35.62/21.76)	G..GGTDVNAMDALDTMGYDM
  690-  709 (23.03/11.03)	GgdGGLDNLELD.LDVTEEDF
  765-  782 (23.98/11.84)	T..PALDTHMTDLLATPNYD.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.77|      17|      27|      39|      64|       5
---------------------------------------------------------------------------
   39-   55 (32.91/33.79)	W.LDPSASPKNPTTLITA
   68-   85 (28.86/ 9.36)	WqLQPSAKPSAPSSKMDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.08|      15|      17|     729|     745|       7
---------------------------------------------------------------------------
  729-  745 (19.85/21.26)	PlSNMQsMDAFFSTKNE
  749-  763 (28.23/17.90)	P.SDMM.LDSLQYTGTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.84|      20|      93|     424|     443|      11
---------------------------------------------------------------------------
  424-  443 (33.56/19.79)	QGGLLMKALKEPVLSSPLMA
  520-  539 (35.28/21.24)	DGGLLSRSTSTPSSATLVMA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.05|      32|     105|     215|     247|      15
---------------------------------------------------------------------------
  215-  247 (51.64/26.63)	IFQPSTRRIRLRPL..IPSDLHSTATTKGaKEKGL
  322-  355 (53.40/24.26)	VYYPSRLVFALTPTrqSPSALAGMNGTLG.YNHGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.73|      30|     654|    1042|    1086|      17
---------------------------------------------------------------------------
 1055- 1084 (54.32/51.98)	RSPSSSTT......TTTPGQDQRKEKDGG..NDTED.SE
 1089- 1127 (39.41/10.29)	QSLTSMTTaadgyaTGGGGGFSAGEHDAGleNGSSHwSE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07528 with Med13 domain of Kingdom Fungi
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