<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07522

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMTSSLRDQVNDLLTEYTLVSQRYFQSLIQVAEDTPLDPQQSPEFYIQEMVKVDTQLQFALDQSKHEKITLPHPVLTFVNLLFTTLSLSLSLFTTLSLSLSLFTTLSLSLSLFPPVGEHQARQQQIIKVQDDIQDHQATLLSMVEQLNIANQDLEQTLNGAKKELQAADYAKKANIQFTDVLSYASKLSKYTSAPPNFDLMNRDIKVYFEKPYPDEERIRRGLLYWQHSSQPIPEDKFESSDNESMSDENSDTKKDEPASTEEDGPAPFWLLDLNP
Length275
PositionMiddle
OrganismAbsidia glauca (Pin mould)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Cunninghamellaceae> Absidia.
Aromaticity0.09
Grand average of hydropathy-0.489
Instability index48.06
Isoelectric point4.53
Molecular weight31412.82
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07522
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.85|      14|      15|     125|     139|       2
---------------------------------------------------------------------------
  125-  139 (20.39/17.54)	IIKvQDDI..QDHQATL
  142-  157 (17.46/ 9.52)	MVE.QLNIanQDLEQTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.38|      16|      17|     200|     216|       3
---------------------------------------------------------------------------
  200-  216 (24.89/17.56)	MNRDIkVYFE...KPYPDEE
  218-  236 (24.49/12.70)	IRRGL.LYWQhssQPIPEDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.50|      12|      19|      23|      36|       4
---------------------------------------------------------------------------
   23-   36 (17.67/17.77)	YFQSLIQVaeDTPL
   45-   56 (21.83/14.23)	YIQEMVKV..DTQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07522 with Med4 domain of Kingdom Fungi
Unable to open file!