<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07518

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMQPTLSPTEEIESTKTNGYAKHEEINGKPLNAVQETTTTTTMSSSSESEERVVLPVEMASMVPLKALMGKLIHKAHADLITLTETLPSMSEVEKKRQILTYTTFVRKQFLKLLVLVKWAENANDIQMCQNIMAFLANQNQIFTSTVDFLHKIYTELPAARLRNFDIPTAVDVLTTGTYQRMPTKIKDMLTPTPLTDQEVLETFQNMNDVIRMRMITTEVLPSPMRKYRIENGRIYFSIKNEFEVALTLMGHSNDRRWWIVSLDVFVQATSVGGASEDVDISLNDNQKQHLRVNAQKQLVPPNPDEPTKLFFPLVNMYDYLHLCCLNMQLEILYIQAAMLSKTRWMNQLKVQMNQDRTKLTVIYWRGGSPASQWARPQANSKGIKSTVLEISVSHPDQQPQPENVAVAVRDELKGLIQKAGIGASIALSDLTANEQPRVLSSLKYPKHCLDVLWDESADLHTERKLLDSANLNLEQLVLHVTNYHGKCIIDKFRQLLNSQKDFLEENGLHLAEEESRDGSQSTLVNETSDSTPSLVVRYRHQRYISIECDARTGRVKASEAGDGCSEGDFKLRGLEDRLNNDPQDIARHLLWLRSEVVVREVIALAKQLNLQPYHPSQMNLRPEDLQKLFGDLLSDATTTSTTTATASSGSSKYPSHCMFLQFSQFEDWYFIIATVKNEFKAWLCCINKTYDQNGLYQAIVDLAHFDCNQVWKDQFAEKLPSTSKNIEDAYTSATNTHTHKRKLEVGQEDAPATTHDDIKRRRMSMRRDDSEAVPLAKIDNLSIDLRFLAKLDSLCRAYITNRMIELQLQSFKGSLKYHMRPLLQSLSSTETQVMNHPAADKMEVVCVSQRDLLKTCAYHFADDGTKREKPTETIPWIEKLLPSLKNDVLIRSFGWWDCGRGDCYVVVQDKFDWKHLQLQGNDLGDHISLDKLTNVLSFTYPNIDTCIDKFLMDWERIFMMANLTRQMSSSWFEKYSEQLSFKATNLQELSFSYAKDFTCTIQWSSSSKGHPRQYNIELGTTDDANKAKPTALPTLNSRNPHWRIASFLRDVLNDKKDLIYFVQILFQTLPLMACLERLEVECAQKGDIGKVSIIPRAYDSVRVIFSAMHAIDIRFTDKATICVSDAAYHHLYYSSRTTSADTFIAPQPYLVQAAAAPPPPSETVSGNMKPIKVAQQFKFTPIEQFADLLKSMETWIFSFEAKDVDRWYVSGELWDQKTEPSAVSLQHGLLCSASLCQGILNKLQQVL
Length1247
PositionTail
OrganismMucor circinelloides f. lusitanicus CBS 277.49
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Mucor.
Aromaticity0.08
Grand average of hydropathy-0.366
Instability index45.94
Isoelectric point6.18
Molecular weight142131.63
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07518
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     773.84|     257|     360|     322|     639|       1
---------------------------------------------------------------------------
  322-  621 (384.57/386.79)	LCCLNMQLEI..LY...IQAAMLSKTR.WMNQLKVQMNQDRTKLTVIYWRGGSPASQWARPQANSKGIKSTvleisvSHPD........QQPQPENVAVAVRDELkgliqkagigaSIALsdltaneqpRVLSslKYPKHC............LDVlWDESADLHTeRKLLDSANLNLEQLVLHVTNyhgkciiDKFRQLLNSQKDFLEENGLHLAEEESRDGSQSTLVNETSDSTPS.....LVVRY......RHQRYISIE..CDARTGRVKASEAGDGCSEgDfKLRG.LEDRLNNDPQDIARHLL.WLRsevvVREVIALAKQLNLQPY..HPSQMNLR
  683-  982 (389.27/270.21)	LCCINKTYDQngLYqaiVDLAHFDCNQvWKDQFAEKLPSTSKNIEDAYTSATNTHTHKRKLEVGQEDAPAT......THDDikrrrmsmRRDDSEAVPLAKIDNL...........SIDL.........RFLA..KLDSLCrayitnrmielqLQS.FKGSLKYHM.RPLLQSLSSTETQVMNHPAA.......DKMEVVCVSQRDLLKTCAYHFADDGTKREKPTETIPWIEKLLPSlkndvLIRSFgwwdcgRGDCYVVVQdkFDWKHLQLQGNDLGDHISL.D.KLTNvLSFTYPNIDTCIDKFLMdWER....IFMMANLTRQMSSSWFekYSEQLSFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.98|      22|      23|     160|     181|       2
---------------------------------------------------------------------------
  160-  181 (37.88/24.23)	RLRNFDIPTAV.DVLTTGTYQRM
  184-  206 (33.10/20.23)	KIKDMLTPTPLtDQEVLETFQNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.31|      13|     601|      36|      48|       3
---------------------------------------------------------------------------
   36-   48 (23.47/11.83)	TTTTTTMSSSSES
  638-  650 (22.84/11.35)	TTSTTTATASSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.51|      19|     132|      78|      96|       4
---------------------------------------------------------------------------
   78-   96 (33.25/20.72)	DLITL....TETLPS.MSE..VEKKR
  208-  233 (20.26/ 9.85)	DVIRMrmitTEVLPSpMRKyrIENGR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07518 with Med14 domain of Kingdom Fungi
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