<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07516

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLTDSSLTNILVVSGVSQIRYRVYNQHITRESLETFFSHSPHDAVNKDMALLRAYTEMTALSIPTLWRVRAESSEPGKDLELELWVFWFDERHTGKIDANDHLYALDETKVGSFTWENAYSKIQSPTASPGPLSTQSKTSIPVTVSEEYKWFIKSVRNLIHVQMKKNGAFPLGEFYVYPNTDQDVIADVKSSSPSLLQLTQSVLCCSYSIYLASTNLIFQPNTRRMRLRPITLQTIRTRGKKVIISPTGETMLIANNNTTQPLSPQLEETILKKWSLMLDIPYTNLMPYASSQQQHASHDRSEPPSRKPHARQQLPNLVAIKSPASGEDSYYYPSCLIFVSSSSKISPTAMAGVNGLFGFNQGFSEDLGDKWHRWAWSERISNYWEYTCPREATTSVVLDTLSVDNGQSNSSNIGLLQKAINEPVIASPLMATKSVATPGSATGNQRNEMSTPSSSTNNYDEDDPQQQQQQQQQQQPQLQHPLHQRSKSRYQSGLSLVDFALAHFSMPNSTDDLVEYPILPQSTPVLQQANEPTIQQQQNHLPLQPMPQQQTQQQQQQQHQGISNNTTANNSTYQSPQMPNLELDAYGGMVESMDVDNMVLDIPNRWTDDGMDDLDNFDFGVTEEDFDFFESSGPTSVPAAAANTTTANDPLASLQQVQQDATTTLTTTHDSLLLMQEIKPEDMDISSNFDPTLMDLDQKQQQEILDTDLDSQQNDLSLTPLQVGMAQHDPFNSHTSDPVKHEPSPLPPPSQPPAASYDYHQQLFVPPQFAPIKIESVVNDAKYVQGGKFTYPAQDSQPLTKRKQSTDYRPDYVPVMRSSKKNKRKSSKLLLLDTINKENKPLELLDDDMMMVREDQQRHVKSASTITSSSSSEEASSSDQSSDSSAEDDDSEEDDDDDGDNDASTKITRTMKSLSIAQRKLVDQLTRMDTSDAGTTRKKADADQITMDYDTPFARAVTDSVIRVAGARTEVNELEETKALDYLCQQAVMGGYPFSGGIEAMSSNGFEANEGESAKVVIARRRNLLQKYNGDTIHVPSTPSDVEFMNQSFKHVLSDIFYQQQRPGNSDLDAMCMDTLPLPASVTVKGPLNVQDYYELSETNQAHSKYGKYQVKKRRPAEPNLGTLQPPNITVNRQDDTIEGTSKLIMFWEKLRLEPYSLKKQVNYFVVYPKNESIENGITHFFKGLGTVYETCQLGTHHAAATVGPYRRGLVPVTLLPPLENESFQDRQLRSYMQECQHLGSVLGSAMPENVHIVIYMVNPATHLASHLDLSRCFSKLKAAYNTSSMALSDKTRARLVLQLMPIEHVLRSTSFGGCLKFGMKEIAFSVYSKCHAIVNRQHQSHPVADVYAPPFVLSKPVPSHIHFKLKKAISAFPSILESPAVLHMGYTFSLDKRWMIIVWTDNRGEMVEFAVLDNHRHQLPLTSVFEEAWRRTRQISKRTGFAWTFVICKMGLMFEDELTAWIACLPSNAHVAIVSLDVESTLYVNTTNAETTHEMHAPADTLNTNTPTMMNTAAATTKKMFSPDTQDNGQTKALLLNHRVAYSNKRERMSFGMLGLDSISKEDWMIPLASGYMIHTPPTTENPNNELFNCSPLVLEIHLVYNQTNHSAYSTLRDIIKKYHALSFVNVMPSNSNCFPLHLALVERLSRILLVVPS
Length1656
PositionKinase
OrganismMucor circinelloides f. lusitanicus CBS 277.49
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Mucor.
Aromaticity0.08
Grand average of hydropathy-0.511
Instability index55.90
Isoelectric point5.55
Molecular weight185860.74
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07516
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.71|      16|      16|     584|     599|       1
---------------------------------------------------------------------------
  584-  599 (29.70/18.15)	LDAYGGMV.ESM.DVDNM
  601-  618 (23.00/12.34)	LDIPNRWTdDGMdDLDNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.49|      34|      47|    1156|    1196|       3
---------------------------------------------------------------------------
 1156- 1196 (51.56/48.63)	PYSlKKQVNYFVVYP.KNESIENgithffKGLGTVYETCQ.LG
 1206- 1241 (54.93/32.76)	PYR.RGLVPVTLLPPlENESFQD......RQLRSYMQECQhLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.82|      26|      82|     468|     493|       4
---------------------------------------------------------------------------
  468-  493 (50.84/33.98)	QQ.......................QQQQQQQPQLQHPLHQRSKSRYQS
  528-  576 (35.98/21.53)	QQaneptiqqqqnhlplqpmpqqqtQQQQQQQHQGISNNTTANNSTYQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.02|      43|      47|     880|     926|       5
---------------------------------------------------------------------------
  880-  926 (59.70/44.42)	DqSSDSSAEdddSEEDDDDDGDNDASTKITRTMKS..LSIA.QRKLVDQL
  930-  975 (61.32/33.94)	D.TSDAGTT...RKKADADQITMDYDTPFARAVTDsvIRVAgARTEVNEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.56|      40|      66|     179|     221|       6
---------------------------------------------------------------------------
  179-  221 (58.89/47.51)	PNTDQDVIADVKSSSPSLLQLTQSVLcCSYSIYL..ASTNLIfqP
  247-  288 (67.67/41.81)	PTGETMLIANNNTTQPLSPQLEETIL.KKWSLMLdiPYTNLM..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.77|      14|      15|      77|      91|       7
---------------------------------------------------------------------------
   77-   91 (21.68/20.63)	GKdLELELWVFWFDE
   95-  108 (22.09/14.50)	GK.IDANDHLYALDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      55.42|      12|      40|     650|     661|       8
---------------------------------------------------------------------------
  650-  661 (20.88/ 9.23)	DP.LASLQQVQQD
  691-  703 (17.46/ 6.54)	DPtLMDLDQKQQQ
  720-  730 (17.08/ 6.24)	TP.L.QVGMAQHD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     144.17|      47|     221|     802|     852|       9
---------------------------------------------------------------------------
  802-  850 (73.07/55.28)	KRKQSTDYRPdyVPVMRSSKKNKRKSSKLLLLDTINKENKPLELLDDDM
  854-  878 (24.85/11.79)	REDQQRHVKS..ASTITSSSSSEEASS......................
 1545- 1575 (46.25/28.14)	..................SNKRERMSFGMLGLDSISKEDWMIPLASGYM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.99|      25|      40|    1261|    1300|      10
---------------------------------------------------------------------------
 1261- 1290 (33.35/56.03)	PATHLASHLDLSRCfskLKaaYNTSSMALS
 1303- 1327 (44.64/25.63)	PIEHVLRSTSFGGC...LK..FGMKEIAFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.91|      18|    1201|     154|     171|      11
---------------------------------------------------------------------------
  154-  171 (33.72/21.41)	KSVRNLIHVQMKKN.GAFP
 1357- 1375 (30.19/18.42)	KPVPSHIHFKLKKAiSAFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.59|      53|      89|     981|    1037|      14
---------------------------------------------------------------------------
  981- 1037 (83.42/79.08)	LDYLCQQAVmgGYPFSGGIEA.MSSNGF....EANEGES..AKVVIARRRNllQKYNGDTIHVP
 1069- 1128 (79.17/60.30)	LDAMCMDTL..PLPASVTVKGpLNVQDYyelsETNQAHSkyGKYQVKKRRP..AEPNLGTLQPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07516 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DFALAHFSMPNSTDDLVEYPILPQSTPVLQQANEPTIQQQQNHLPLQPMPQQQTQQQQQQQHQGISNNTTANNSTYQSPQMPNLELDAYGGM
2) INKENKPLELLDDDMMMVREDQQRHVKSASTITSSSSSEEASSSDQSSDSSAEDDDSEEDDDDDGDNDASTKITRT
3) KYGKYQVKKRRPAEPNLGTLQPPNITVNRQD
4) MDISSNFDPTLMDLDQKQQQEILDTDLDSQQNDLSLTPLQVGMAQHDPFNSHTSDPVKHEPSPLPPPSQPPAASYDYHQ
5) NMVLDIPNRWTDDGMDDLDNFDFGVTEEDFDFFESSGPTSVPAAAANTTTANDPLASLQQVQQDATTTLTTTHDSLLLMQEIKPE
6) QGGKFTYPAQDSQPLTKRKQSTDYRPDYVPVMRSSKK
7) RKLVDQLTRMDTSDAGTTRKKADADQITMDYD
8) SPLMATKSVATPGSATGNQRNEMSTPSSSTNNYDEDDPQQQQQQQQQQQPQLQHPLHQRSKSRYQS
499
836
1106
684
598
786
920
428
590
911
1136
762
682
822
951
493










Molecular Recognition Features






MoRF SequenceStartStop




NANANA