<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07509

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTVDVETNVLLINNITSVEYRFYEPSADSKQTFYPNSLKIETNLREQGHIVSFDATRRGLWYFRIQRSVDAEPEAPTELGATVTVNGQSLVSAKNGSMQPSMWYKALAPELPNPQRPNTTTSVQPTPFHITGPQQGHEATAIVEQTELQEADGYAPKTLYESFIGSLLLTICSNFCARSEAVPLNFRTVLLPALKSPAATDQWVGEQAQALGTLKCYMISTGSLILTFSVTICPGLASLEDILTTNPSPIGSNILAAPFGVMTNEEQQPPSHSSGSNLAHTPSTQALAQISPSDANSSLWKQACLAVLELRGVPGAALRDCSWVNLLISKPKLQDTRPENGRGALSTISIPWPGSLCFRKKAVELSATNRISDTIVAGHDEMHDPLGDARRWLSSANEREERVSKRHTERSAAGAKENLTVDARLAKMNAPSPVTMRRPSTTGINAVYPTPPDAIQNLNGVTPSMDGNLSSPGHPLSVVADVDIDCEPPGGAGSIHHHDDEMTEATDAKPPRSENNLLGEAEDMFDDMGGDMFGDNDITEADFNFFDEQPDELGMDMSLDSIKAASTSTSTPIKAEEPSLPASATIPPAVEPIVFAKPQLKHARSSQLEEGLQRGRELQAKSTKRGSSPFDPDSVFKRLRAAVSQQTQRAAHGPGSSRGTKVFGTVDFDPKMPMLNKKYEHGGFFDFVQLDKDATKLEPGTLPKTDYLRRHSKSKAKPQARSRRSSLVKSGNESDSQLLDHQLLNLDGDISDGDDSSSGSDGVSSVSVKEPISPVKSTVKQSLLGEDDAASYTTTSRDQDLAEEPDEQLALELPRLSLLDQPDTSLFKYFADPEPLGLHTFLNDEDLIQVAQLVAEQAATGSLTIFNDQSDVGLLPTTEEDARIEQLAGSRSALQALRDAASSILGSVAPVGLKSLLEIQDGSLPGQGNRVQPRQVPPRDSNSEPIKPSSLYQIPCPHLEVRRADVKMSLLPTAVTFWENLGLAPSSGSKDVHAVCVCPNWTGMVDNAQTFLGRLKSVYETLKLGIFEKLPLSADMDDGLLLYGVDQISTAPDAAMMWNGSALLEGIETLSGAMSDLDIVDTNVVVYFLYSATNPGTIVQACLAFQRFFDSYRRTLSAKRESSKNEIVLQLVPADAVSSSTSMVVTSSSELVKLCMETYDRCTLFGGNMPAPAIRLEQPLPRIIDFKLSPAPSSSLARENSCIHIAYARSIDGRWVTAAWTDDRGNEQATAAYCLGRKGEPESRTMNEVANEIWETTVGLISTWKVHYRIIMTKCGPTDEGEVDFWVDLARTEINASVTMIVMTVDTNPSLQLVPAPIKTSLQPLSIYTTPVSTPQANIVSPEASATPVTPARDTVATVATPGGDSNGDADVDSVLADVMDQTWGAVANHRLNNAIGTTSIQPALISGYLIKRTGPKADDVPTIMEVNLVYTEAAARTYEPLLREMLSYFRGLGTLARARGVVDRETDVRPWHVAAAEKALRALYILM
Length1489
PositionKinase
OrganismCordyceps confragosa RCEF 1005
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Akanthomyces> Cordyceps confragosa.
Aromaticity0.06
Grand average of hydropathy-0.299
Instability index46.97
Isoelectric point4.91
Molecular weight161179.42
Publications
PubMed=27071652

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07509
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     385.50|     120|     143|    1171|    1297|       1
---------------------------------------------------------------------------
 1171- 1297 (193.60/142.49)	PAPAIRLEQPLpRIIDFKLSPAPSSSLARENSCIHIAYARSIDGRwVTAAWTDDRGNEQATAAYclgrkGEPESRTMNEVANEIWETTVGLISTWKVHYR.IIMTKCGP.TDEGEVDFWVDLARTEINA
 1316- 1437 (191.90/120.17)	PAPIKTSLQPL.SIYTTPVSTPQANIVSPEASATPVTPARDTVAT.VATPGGDSNGDADVDSVL.....ADVMDQTWGAVANHRLNNAIGTTSIQPALISgYLIKRTGPkADDVPTIMEVNLVYTEAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.42|      41|     137|     762|     817|       2
---------------------------------------------------------------------------
  511-  558 (47.79/15.33)	PPRS..ENNLLGEaedmfDDMGGDMFGDNDiteADFNffdEQPDE.LGMDM...
  775-  817 (65.52/47.93)	PVKStvKQSLLGE.....DDAASYTTTSRD...QDLA...EEPDEQLALELPRL
  872-  895 (29.11/ 6.50)	...................DVGLLPTTEED...ARI........EQLAGSRSAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.18|      16|     315|     113|     128|       3
---------------------------------------------------------------------------
  113-  128 (34.21/19.05)	PNP...QRPNTT..TSVQPTP
  432-  452 (23.97/11.00)	PSPvtmRRPSTTgiNAVYPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.65|      27|      39|     595|     633|       4
---------------------------------------------------------------------------
  595-  625 (31.63/29.43)	VFAKpqLKHARSSQLEEGlQRGrELQAKSTK
  636-  662 (45.03/38.04)	VFKR..LRAAVSQQTQRA.AHG.PGSSRGTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.66|      31|     598|     453|     485|       5
---------------------------------------------------------------------------
  453-  485 (47.98/37.67)	PDAIQNLNGvTPSMDG..NLSSPGHPLSVVaDVDI
 1053- 1085 (50.68/30.67)	PDAAMMWNG.SALLEGieTLSGAMSDLDIV.DTNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.15|      39|     832|      71|     112|       7
---------------------------------------------------------------------------
   71-  112 (62.49/45.09)	DAepeAPTELGATVTVNGQSLVSAKNGSM......................QPSMWYKALAPEL
  559-  581 (25.59/ 9.39)	...................SLDSIKAAST......................STSTPIKAEEPSL
  900-  960 (53.07/30.21)	DA...ASSILGSVAPVGLKSLLEIQDGSLpgqgnrvqprqvpprdsnsepiKPSSLYQIPCPHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.64|      47|     833|     246|     299|       8
---------------------------------------------------------------------------
  246-  299 (72.05/60.21)	TNPSPIGSNILAapFGVMTNEEQQPPSHSSGSnlahtPSTQALAQISPSDANSS
 1094- 1140 (79.59/48.47)	TNPGTIVQACLA..FQRFFDSYRRTLSAKRES.....SKNEIVLQLVPADAVSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.54|      15|     832|     204|     218|      10
---------------------------------------------------------------------------
  204-  218 (30.88/19.97)	WVG..EQAQA.LGTLK.CY
 1002- 1020 (16.66/ 7.35)	WTGmvDNAQTfLGRLKsVY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07509 with Med13 domain of Kingdom Fungi
Unable to open file!