<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07506

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMASGDGPPLSMRPFPVADKSPKNLADFIARVNALPGGFRSVTETSLEEDIHARNETDGEDVDMSSDADDDNDDDDEEEDASAKDPVVARMEVLKHIDIASNTAMLTLDSLSLLLSKQHPTQAGLTLSQQLRDMVGIGTLGADRLDDANTTPAKTADQAAVALGWTLTEINRARDAADDATAFLTAEMAAEGRYWEGVMGIRQAGWSVCRMPQERQTLGVRFGFSEAAADFKRNGLAPIRRGDDGEARLDIGRLGGTPERLVVTYERNGQVVGRAAPQELGDEEESLEARVLGARNTIFAQELWHELTREARSLAAYDVHPDGEKRLVCAVDGENARIIVELLPVADCQHPADEKQLPEDTTAQAISLALHILLTYAHRCNELLRIRPLPPHIPRTRGQQIYTLLRPIVARLLFARHAAACTALVGSLTRTLRSAGLAASSFTLRTPQPTVADLATAGPNQPSAAVNLVRAMLQPTDFALEIALLPDVAFTVRGRTYLVPVTATYYHVLAPADAAIHTLCAPYADGYPELQALSDYLCMAATRALAAHHGEKLKAASTGEGEEAWALGVHGTRIRNTKDLDRSQLDFAVTQEADGNLQLKVSSVPSGGAASLSSTDGEAAPPKASAAAAAGQSWTWTSSKDSSAQETLEAVVEKVLKN
Length657
PositionHead
OrganismCordyceps confragosa RCEF 1005
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Akanthomyces> Cordyceps confragosa.
Aromaticity0.05
Grand average of hydropathy-0.253
Instability index40.10
Isoelectric point4.94
Molecular weight70461.20
Publications
PubMed=27071652

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07506
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.25|      27|      33|     132|     164|       1
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  132-  164 (36.14/24.72)	DMvgigTLGADRLDDAntTPAKTADQAAVALGW
  168-  194 (46.10/18.73)	EI....NRARDAADDA..TAFLTAEMAAEGRYW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.32|      27|      33|     333|     365|       2
---------------------------------------------------------------------------
  336-  365 (41.20/42.97)	RIIVE.LLPVAdcqHPADE....KQLPED...TTAQAI
  366-  400 (34.12/17.00)	SLALHiLLTYA...HRCNEllriRPLPPHiprTRGQQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.23|      28|      33|     202|     234|       3
---------------------------------------------------------------------------
  202-  234 (42.36/36.56)	QAGWSVCRMPQERqtLGvrfGFSE.AAADFKRNG
  240-  268 (44.87/24.88)	RGDDGEARLDIGR..LG...GTPErLVVTYERNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.97|      12|      25|     277|     288|       4
---------------------------------------------------------------------------
  277-  288 (19.61/11.95)	QELGDEEESLEA
  304-  315 (18.36/10.69)	HELTREARSLAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.24|      22|      23|     499|     520|       6
---------------------------------------------------------------------------
  472-  507 (28.52/13.34)	LQPTDFALeiallpdvaftvrgRTYLVPVTATYYHV
  508-  529 (40.72/21.99)	LAPADAAI..............HTLCAPYADGYPEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.11|      23|      36|      43|      66|       7
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   43-   66 (33.84/27.68)	ETSLEEDIHARNETdGEDVDMSSD
   79-  101 (37.27/25.09)	DASAKDPVVARMEV.LKHIDIASN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07506 with Med17 domain of Kingdom Fungi
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