<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07504

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDSQPSAARSALQEAAKYWSEFVARCIAQRLSSDRFQDFVQLVHAKHPLPPVLVADFFLRPQPSNHVSLDPRIPPYIQILTHLGYVDAPSILRVLYKYSALHVYDKPHADHNGETKREDGEETKQDKTVHWQDSSWAEEVLMYHVIKNMVEGTAFTGAKAGLELITITCKWMDRFINVSSTIAADILTNKHDRQGLAEMEAVRAALAALLLRMLDNHALLRIISKPFAKGLRKHLSDSLGSFIPTLQPVTPAFVERLEIFRTQTLAQLDPPDKKKKAANAVMDELLDSTVGLESFVIPEIPISNSRAALYVYLNAAKLVGRPVLDDAMLYAFLNNKYQGNQQSSAIDLIIASFDLLANAVFRNEGPKDASLLRSFVVNKLPLLLCQLCHPEFSATSAEFCITEALSRIDTSVFPTASLMFDESRNNNPYMDSVREEFCAACALHGLIERDHVDRILGETSMSYDPSLEKANRDRLVSDCLSDSGKIQNIISQLDKVDGNVGAVAHAIVELIRQLCINKDTMALKPLCTQLAQKPQSLDIILLFEKITSILEPVCSLLDNWRYEEDQGEYQPVYEEYGAILLLVFAFTYRYNLSPLDIGIQSVDSHVAKIITKSHILRPLDELSEQEMGHVTGWINGLFDNETGGLGDDLMSSCPPHEFYLLVAPIFQSIITAYTYGYINDESLKGGVEYLVDTFLLPSLVPAIRFLSDYIWVDQKEQKSIVKALQLLLTPSSISGEASTVLSSVKNLIAQPLEHALRTYQRQDPRNQDIEPLLRSLKENIPQSRRTGGAEHHEMESWANSSSNGLFGAIRHTMQGLVQWSLQPGVNVMPASYTHRQFIAGVRIIGPSRLLRLIMEEIRQQSDLGNAPVVYDVAAALVAATDSTNDTPPVSSNLLDTAGTMQSPPQRPQSLRDALKTAAEGYKRLQKQDPFLAEAMVRLHRRVETLMVMPQAQALLPTADMPLDLSGDAIAAAAAAGADPLAVDTTGLDMGLGGDLDLSGGGGDADLFGGLDTSMDMFDGWDSMDMGDMGVN
Length1031
PositionTail
OrganismCordyceps confragosa RCEF 1005
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Akanthomyces> Cordyceps confragosa.
Aromaticity0.07
Grand average of hydropathy-0.109
Instability index45.64
Isoelectric point5.08
Molecular weight113947.71
Publications
PubMed=27071652

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07504
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.93|      14|      18|     778|     795|       1
---------------------------------------------------------------------------
  778-  795 (20.78/22.24)	EnipqSRRTG..GAEHHEME
  799-  814 (21.15/11.04)	N....SSSNGlfGAIRHTMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     565.13|     198|     230|     265|     493|       2
---------------------------------------------------------------------------
  271-  493 (296.36/321.09)	PDKKKKA.ANAVMD...EL..LDSTVGLESFVIpeiPISNSRAALYVYLNAAKL..VGRPV..LDDAMLYAFLNNKYQG.NQQSSAIDLIIASFDllanavFR.NEGPKDASL..LRSFV...VNKLPLLlcqlcHP..EFSatsaEFCITEALSRIDtSVF..PTASLMFDESRNNNP...YM..DSVREEFCAACAlHGLIERDHVDrilGETSMSYD....PSLEKANrdRLVSDCLS.DSGKIQNIIS..QL
  496-  726 (268.76/210.30)	VDGNVGAvAHAIVElirQLciNKDTMALKPLCT...QLAQKPQSLDIILLFEKItsILEPVcsLLDNWRYEEDQGEYQPvYEEYGAILLLVFAFT......YRyNLSPLDIGIqsVDSHVakiITKSHIL.....RPldELS....EQEMGHVTGWIN.GLFdnETGGLGDDLMSSCPPhefYLlvAPIFQSIITAYT.YGYINDESLK...GGVEYLVDtfllPSLVPAI..RFLSDYIWvDQKEQKSIVKalQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.29|      15|      19|     880|     895|       3
---------------------------------------------------------------------------
  873-  888 (21.36/13.53)	AAALVaATDSTNDTPP
  890-  904 (25.92/12.06)	SSNLL.DTAGTMQSPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.62|      25|      25|     977|    1001|       5
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  957-  974 (18.83/ 6.89)	.......TADMPLDLSGD.AIAAAAA
  977- 1001 (42.98/26.01)	ADPLAVDTTGLDMGLGGD.LDLSGGG
 1004- 1029 (42.80/25.87)	ADLFGGLDTSMDMFDGWDsMDMGDMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.89|      24|     155|     750|     773|       6
---------------------------------------------------------------------------
  750-  773 (43.90/32.46)	QPLEHALRTYQRQDPRNQDIEPLL
  908-  931 (40.99/29.76)	QSLRDALKTAAEGYKRLQKQDPFL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07504 with Med5 domain of Kingdom Fungi
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