<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07496

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMAGPNEPPLDEIQWRSPQILAGMGGLHSNTILFYFAESPFFERTSNNAVIMSQAMNNMAMYHFIQTREVFEGRLKTMSGLEFIVGEEPAETGPGMGTGVWVIRKQTRRKQQYQEDDEITVHASFFVVGENIYMAPTLADILASRIMTVSAALGKALPPAESIRTWRPSIGHVYQPPTNTSGSFSFAAGSRAKAAQESTEGTPLPDGSNKQQQQYQQAGSSRKNDEPELQRRAEEAFWIHMKYGGEYINENPITGRPGEFHLSSTGRKAVPLPKKGPESGMGAMNGPAVNSKTDSSKKDAKAPKTPKSATTPRIKRKKSKMSAANTPSMS
Length329
PositionHead
OrganismMoelleriella libera RCEF 2490
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Moelleriella.
Aromaticity0.08
Grand average of hydropathy-0.643
Instability index57.71
Isoelectric point9.41
Molecular weight36044.32
Publications
PubMed=27071652

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
ECO:0000256	PIRNR:PIRNR013286
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP07496
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.17|      16|      22|     218|     233|       1
---------------------------------------------------------------------------
  218-  233 (27.34/13.10)	GSSRKNDEPELQRRAE
  243-  258 (29.83/14.78)	GGEYINENPITGRPGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.54|      39|     100|      69|     114|       2
---------------------------------------------------------------------------
   69-  114 (58.70/36.64)	VFEGRLKTMSGLEFIVG......EEPAETGPgMGTGvwvirkQTRRKQQYQE
  172-  216 (64.84/27.25)	VYQPPTNTSGSFSFAAGsrakaaQESTEGTP.LPDG......SNKQQQQYQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.06|      13|      20|     142|     154|       4
---------------------------------------------------------------------------
  142-  154 (20.54/11.37)	ASRIMTVSAALGK
  159-  171 (24.51/14.71)	AESIRTWRPSIGH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07496 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) INENPITGRPGEFHLSSTGRKAVPLPKKGPESGMGAMNGPAVNSKTDSSKKDAKAPKTPKSATTPRIKRKKSKMSAANTPSMS
2) PTNTSGSFSFAAGSRAKAAQESTEGTPLPDGSNKQQQQYQQAGSSRKNDEPELQRRAEEA
247
176
329
235










Molecular Recognition Features






MoRF SequenceStartStop




1) TDSSKKDAKAPKTPKSATTPRIKRKKSKMSAANTPSMS
292
329