<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07492
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MAGAADSQPAAGHHPQQEAARYWSDFIARCVAQRLSGDRFREFVRLVYARYQLHPLLIAELFLRPQLSNCVSLDPRIPPYICVLTELGYVDAPSILNRLYRYSALHAYTKPLADAGQDANANDSNKEGDKAQEKTPVRWKDSTWAEEVMFYHVIKTMAEGTAFTDTKTGLELIIIACKWMNLLAQVSSRFAADILVSDHDRLAREGLATVRLALIPLVLRLDNAALLRILVRPRAKVIRRFLSDSLGDFIPTCQPSPFVDRLEIFRTQTLVQLEPIDGKKKATNEAMDELLDSTVGMDSFVIADIPIANSRAALYVHLNAAASFVGRPVLDDAMLYAFLNNKYQENQQASAIDLIVAAFDVLANAVFRNEGPKDAHLLRSFVVNKLPLLLCQLCHPEFSAASAEFCITEALNRIDTSIFPTASLMFDETRNNNPYMDSVREEFCAACALHGLIERDHVDRILGETSMSYDPSLERANRDRLVSDCLSDSGKIQNIISQLDRVDGNVGAVAHAIVELIRQLCMNKDTMSLKLLCTQLAQKPQSLDIILLFDKVTSILEPVCTLLDNWSYEEDQGEYQPVYEEYGAILLLVFAFTYRYNLSPLDIGIQSADSHVAKIVNKSHILRPLDELSEQEMGHVTGWINGLFDNETGGLGDDLMSSCPPHEFYLLVAPIFQSIVTAYTYGYINEESLKGGVEYLVDTFLLPSLVPAIRFLSDYIWVDQREQKSIVKALQLLLTPISISGEASAVLSAVKNLVAQPLEHALRTYQRQDPRNQEIEPLLRSLRESIPLSRRTGGAEHHEMESWAGSSSSGLSGAIRHTFQGLVQWSAQSPGAGGVGGVVAVVPNAMPASYTHRQLIAGQRIVGVSRLLRLLMEEIRQQSELGNASVAYDVAAAVIAAADSTNELPPPPNLLDATASVMQPPLRPLGLREALKTAAEGYKQLLKHDPFLAEATVRLHRRVEALLAPPPPQVMLQTTDMPLDLSGAEAMAAAVAGGADPMAVDGLDGTGLDMGSLGADLGGGAGAEADLFGGLDTTSLDMFDGWDSMDMGVN |
Length | 1050 |
Position | Tail |
Organism | Cordyceps fumosorosea ARSEF 2679 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Hypocreomycetidae> Hypocreales> Cordycipitaceae> Cordyceps.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.021 |
Instability index | 41.43 |
Isoelectric point | 4.98 |
Molecular weight | 115197.19 |
Publications | PubMed=27071652
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP07492
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 56.38| 18| 18| 695| 712| 1
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695- 712 (31.20/23.73) YL.VDTFLLPSLVPAIRFL
715- 733 (25.18/17.56) YIwVDQREQKSIVKALQLL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 173.12| 35| 36| 977| 1011| 2
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885- 919 (34.48/15.79) .....SVAYDVAAAVIA.........................AADstnelPPPPNLLDA.TASVMQ
923- 976 (26.35/10.28) RPLGLR..EALKTAAEGykqllkhdpflaeatvrlhrrvealLAP.....PPPQVMLQT.TD....
977- 1011 (62.41/34.72) MPLDLSGAEAMAAAVAG.........................GAD.....PMAVDGLDG.TGLDMG
1013- 1048 (49.88/26.23) LGADLGGGAGAEADLFG.........................GLD.....TTSLDMFDGwDSMDMG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 57.56| 18| 21| 299| 319| 3
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299- 319 (23.68/25.83) SFViaDIPIANSrAALYVHLN
323- 340 (33.89/22.26) SFV..GRPVLDD.AMLYAFLN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 74.79| 16| 37| 396| 411| 4
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396- 411 (27.60/17.72) PEFSAASAEFCITEAL
417- 431 (19.31/10.18) SIFPTASLMFDETRN.
434- 449 (27.88/17.98) PYMDSVREEFCAACAL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 52.74| 15| 18| 756| 771| 5
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756- 770 (27.67/20.51) QPLEHALRTYQRQDP
773- 787 (25.07/12.02) QEIEPLLRSLRESIP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 89.75| 29| 38| 194| 222| 7
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194- 222 (46.69/25.39) ILVSDHDRLAREGLATVRLALI......PLVLRLD
229- 263 (43.06/22.91) ILVRPRAKVIRRFLSDSLGDFIptcqpsPFVDRLE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 60.51| 17| 29| 520| 536| 11
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520- 536 (31.33/26.56) LCMNKDTMSLKLLCTQL
547- 563 (29.18/24.15) LLFDKVTSILEPVCTLL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 42.24| 13| 22| 803| 815| 13
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803- 815 (23.25/13.56) WAGSS..SSGLSGAI
825- 839 (18.99/ 9.72) WSAQSpgAGGVGGVV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 66.94| 20| 230| 268| 291| 14
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272- 291 (33.60/26.76) QLEPIDGKKKATNEAMDELL
498- 517 (33.34/16.50) QLDRVDGNVGAVAHAIVELI
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