<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07492

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMAGAADSQPAAGHHPQQEAARYWSDFIARCVAQRLSGDRFREFVRLVYARYQLHPLLIAELFLRPQLSNCVSLDPRIPPYICVLTELGYVDAPSILNRLYRYSALHAYTKPLADAGQDANANDSNKEGDKAQEKTPVRWKDSTWAEEVMFYHVIKTMAEGTAFTDTKTGLELIIIACKWMNLLAQVSSRFAADILVSDHDRLAREGLATVRLALIPLVLRLDNAALLRILVRPRAKVIRRFLSDSLGDFIPTCQPSPFVDRLEIFRTQTLVQLEPIDGKKKATNEAMDELLDSTVGMDSFVIADIPIANSRAALYVHLNAAASFVGRPVLDDAMLYAFLNNKYQENQQASAIDLIVAAFDVLANAVFRNEGPKDAHLLRSFVVNKLPLLLCQLCHPEFSAASAEFCITEALNRIDTSIFPTASLMFDETRNNNPYMDSVREEFCAACALHGLIERDHVDRILGETSMSYDPSLERANRDRLVSDCLSDSGKIQNIISQLDRVDGNVGAVAHAIVELIRQLCMNKDTMSLKLLCTQLAQKPQSLDIILLFDKVTSILEPVCTLLDNWSYEEDQGEYQPVYEEYGAILLLVFAFTYRYNLSPLDIGIQSADSHVAKIVNKSHILRPLDELSEQEMGHVTGWINGLFDNETGGLGDDLMSSCPPHEFYLLVAPIFQSIVTAYTYGYINEESLKGGVEYLVDTFLLPSLVPAIRFLSDYIWVDQREQKSIVKALQLLLTPISISGEASAVLSAVKNLVAQPLEHALRTYQRQDPRNQEIEPLLRSLRESIPLSRRTGGAEHHEMESWAGSSSSGLSGAIRHTFQGLVQWSAQSPGAGGVGGVVAVVPNAMPASYTHRQLIAGQRIVGVSRLLRLLMEEIRQQSELGNASVAYDVAAAVIAAADSTNELPPPPNLLDATASVMQPPLRPLGLREALKTAAEGYKQLLKHDPFLAEATVRLHRRVEALLAPPPPQVMLQTTDMPLDLSGAEAMAAAVAGGADPMAVDGLDGTGLDMGSLGADLGGGAGAEADLFGGLDTTSLDMFDGWDSMDMGVN
Length1050
PositionTail
OrganismCordyceps fumosorosea ARSEF 2679
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Cordyceps.
Aromaticity0.07
Grand average of hydropathy-0.021
Instability index41.43
Isoelectric point4.98
Molecular weight115197.19
Publications
PubMed=27071652

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07492
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.38|      18|      18|     695|     712|       1
---------------------------------------------------------------------------
  695-  712 (31.20/23.73)	YL.VDTFLLPSLVPAIRFL
  715-  733 (25.18/17.56)	YIwVDQREQKSIVKALQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     173.12|      35|      36|     977|    1011|       2
---------------------------------------------------------------------------
  885-  919 (34.48/15.79)	.....SVAYDVAAAVIA.........................AADstnelPPPPNLLDA.TASVMQ
  923-  976 (26.35/10.28)	RPLGLR..EALKTAAEGykqllkhdpflaeatvrlhrrvealLAP.....PPPQVMLQT.TD....
  977- 1011 (62.41/34.72)	MPLDLSGAEAMAAAVAG.........................GAD.....PMAVDGLDG.TGLDMG
 1013- 1048 (49.88/26.23)	LGADLGGGAGAEADLFG.........................GLD.....TTSLDMFDGwDSMDMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.56|      18|      21|     299|     319|       3
---------------------------------------------------------------------------
  299-  319 (23.68/25.83)	SFViaDIPIANSrAALYVHLN
  323-  340 (33.89/22.26)	SFV..GRPVLDD.AMLYAFLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.79|      16|      37|     396|     411|       4
---------------------------------------------------------------------------
  396-  411 (27.60/17.72)	PEFSAASAEFCITEAL
  417-  431 (19.31/10.18)	SIFPTASLMFDETRN.
  434-  449 (27.88/17.98)	PYMDSVREEFCAACAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.74|      15|      18|     756|     771|       5
---------------------------------------------------------------------------
  756-  770 (27.67/20.51)	QPLEHALRTYQRQDP
  773-  787 (25.07/12.02)	QEIEPLLRSLRESIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.75|      29|      38|     194|     222|       7
---------------------------------------------------------------------------
  194-  222 (46.69/25.39)	ILVSDHDRLAREGLATVRLALI......PLVLRLD
  229-  263 (43.06/22.91)	ILVRPRAKVIRRFLSDSLGDFIptcqpsPFVDRLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.51|      17|      29|     520|     536|      11
---------------------------------------------------------------------------
  520-  536 (31.33/26.56)	LCMNKDTMSLKLLCTQL
  547-  563 (29.18/24.15)	LLFDKVTSILEPVCTLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.24|      13|      22|     803|     815|      13
---------------------------------------------------------------------------
  803-  815 (23.25/13.56)	WAGSS..SSGLSGAI
  825-  839 (18.99/ 9.72)	WSAQSpgAGGVGGVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.94|      20|     230|     268|     291|      14
---------------------------------------------------------------------------
  272-  291 (33.60/26.76)	QLEPIDGKKKATNEAMDELL
  498-  517 (33.34/16.50)	QLDRVDGNVGAVAHAIVELI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07492 with Med5 domain of Kingdom Fungi
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