<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP07491

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDAAEYETNVLVLNNVCSIVYRTFEPPRDQSQNFGLKAVDVENEYREQGHIVYYDGSRRILWHFRAVVKDATDECNGNDTGLPDFKRHALIAGDEGTFEPATLQRTRLHQQAGQLPASTTASTSQPLDASQRHALASNPPTGPSITQEQDASSSNSTVVEVHKSGQGNALDSRIVYESFVFATLLSISTALSHRSGAVPLDYRTVLIPKNMARQRLLGDTSYGAPPVVGTLRAYVTSNGDFIVSMAVSVCQGLLSLNEALGQNVAGLGSRILAAPFGMIANGQLSASSESVAISTAQTPGTQALGLRGGPDAHDSTWKQTCLKFLQLRGVAQTRLTNCFWVSLLVARPKLLEARSDLKKSQVLGTMISIPWPSPLCFRRKPVLVPSTSRVGEHILRGHEESHDPLSNARAWFNSTNERDESIAKRKAERVAALQDALPSDSRSQRPNGQSPLNLRRPSAAAAGSMYPTPPDALQNVNGVTPSLDGTLSSPGNALSAVAGPDADQSGQQTTSTIGPFESGPDVTESKGRKSDGNLLGDAEHMFGDMGGDMFGDDDITEADFNFFDEEPGELDLDAALDGLGDSMEENSPLADAQGPEKAAMVSVPIEETELSKAAVVFTKPELRHAISAQNEGPVQRGRGAKAAFAKRESSPFDPHTVFKRVRTSLAAAERANIPTHNARMPRIFERMKFDPTLPMIDKKYEHGGQFDFRRDSSPEQTKSELGAMPDFEHLRRHGKQSRGSISSFSRPTFGFEPLNPASSPGKLETRLSDGYSSSIESDGDEVSGMSNDEAMSPLRSSVKQTIVDEDAASQVTSLKENDLAEEPDHQLAAELPRLTRPTTVETPLSVLFSDPEPLSIDLSLGDEDLIQVAQILTDQAATGTLQFHQSADRAHPSAIGEQTRSGHVVDAKASVRAFRDVASSFFQGIQPARLKRFLDVQDIPLQGQPSRLQPRPIPGRDGSLEQMRLNNLYLIPGPHLEVRRADVKLSVLPSAVTFWESLGLGPSSGGKDITAICVFPNWKGMFDNARTFLGRVKSVYEILRLGSVDSMELPPDEEEGILPFEVDRISTSPDVSLSGGGSSVADRMDILRSALSNLTASSTNVVVYFVYSPNNPGTIIEACAAFQRVFDSYQKELVARKEPAVNELVLQLVSAELLSSPTSVVVTPSPELFRLCIETYDRCTLFGGPMPAPAIRLEQPLPRIIDFKLVNTPSASLTREDSCIHVAYAQTVDERWISAAWTDDRGYQQATASYCLGRKNRSPSTSVNKVAHEIWESTLDLISSWKVHWKIIITKCGPIDQHEADCWANLARQERRASVTMVLMTADTDPFLQFMPPSVKLSPHVVSFYTTPVSTPQANIVSPEQSGTPATPANGTAAATPGGEAGAESEGDAVLTDVTDQTWGAILGHRLSSSLSLVDPQPVLASGYLVKRTGARIEDTPVAMEVNLVHADASPRAYEPLLREVLSYFRGLSTLSRARGMVPADVDVRPWHIAAAEKAARAMYLLM
Length1503
PositionKinase
OrganismMoelleriella libera RCEF 2490
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Moelleriella.
Aromaticity0.06
Grand average of hydropathy-0.326
Instability index48.99
Isoelectric point5.32
Molecular weight162897.91
Publications
PubMed=27071652

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP07491
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.47|      16|      88|     299|     314|       1
---------------------------------------------------------------------------
  299-  314 (31.06/17.62)	PGTQALG...LRGGPDAHD
  370-  381 (19.93/ 8.28)	PWPSPLC...FRRKP....
  385-  403 (24.48/12.10)	PSTSRVGehiLRGHEESHD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.59|      15|      16|     923|     938|       3
---------------------------------------------------------------------------
  923-  938 (24.00/21.16)	QGiQPARLK.RFLDVQD
  942-  957 (23.59/14.63)	QG.QPSRLQpRPIPGRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     402.47|     129|     204|     405|     543|       5
---------------------------------------------------------------------------
  405-  543 (207.31/130.36)	LSNARAWFNSTNERDESIAKRK..AERVAALQDALPsdSRSQRP.NGQSPLNLRRPS.AAAAGSMYPTP....PDALQNV..NGVTPSLDGTLSSPGNalsavAGPDADQSGQQTTSTIGPFesgPDVTESK..GRKSDGNLLGDAEHMFG
  610-  750 (195.16/104.44)	LSKAAVVFTKPELRHAISAQNEgpVQRGRGAKAAFA..KRESSPfDPHTVFKRVRTSlAAAERANIPTHnarmPRIFERMkfDPTLPMIDKKYEHGGQ.....FDFRRDSSPEQTKSELGAM...PDFEHLRrhGKQSRGSISSFSRPTFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.61|      13|     172|     113|     125|       8
---------------------------------------------------------------------------
  113-  125 (23.94/13.71)	GQLPASTTA...STSQ
  282-  297 (17.67/ 8.00)	GQLSASSESvaiSTAQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP07491 with Med13 domain of Kingdom Fungi
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